Optimization and characterization of 1,8-cineole/hydroxypropyl-β-cyclodextrin inclusion complex and study of its release kinetics

Yin, Haoyong; Wang, Chenxiao; Yugan, Jin; Deng, Yun; Jiao, Shunshan; Zhao, Yanyun; Zhou, Jie; Cao, Ting

doi:10.1016/j.foodhyd.2020.106159

Cited by 59 publications

(32 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The linear relation between RSP concentration and RM-β-CD concentration indicates an A L type phase solubility diagram defined by Higuchi and Connors [ 38 ]; also, the slope value (0.1965) is less than unity, revealing that a soluble inclusion complex in 1:1 molar ratio was formed between the guest and host molecule in phosphate buffer 0.1 M (pH 7.4). The apparent stability constant ( K 1:1 ) of the inclusion complex calculated from the slope of the phase solubility diagram, using Equation (1) is 173.38 ± 5.54 M −1 ; this value is within the range of 100 and 5000, which is considered ideal for the formation of an inclusion complex that may improve the bioavailability profile [ 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

Risperidone/Randomly Methylated β-Cyclodextrin Inclusion Complex—Compatibility Study with Pharmaceutical Excipients

et al. 2021

View full text Add to dashboard Cite

Risperidone (RSP) is an atypical antipsychotic drug used in treating schizophrenia, behavioral, and psychological symptoms of dementia and irritability associated with autism. The drug substance is practically insoluble in water and exhibits high lipophilicity. It also presents incompatibilities with pharmaceutical excipients such as magnesium stearate, lactose, and cellulose microcrystalline. RSP encapsulation by randomly methylated β-cyclodextrin (RM-β-CD) was performed in order to enhance drug solubility and stability and improve its biopharmaceutical profile. The inclusion complex formation was evaluated using thermal methods, powder X-ray diffractometry (PXRD), universal-attenuated total reflectance Fourier transform infrared (UATR-FTIR), UV spectroscopy, and saturation solubility studies. The 1:1 stoichiometry ratio and the apparent stability constant of the inclusion complex were determined by means of the phase solubility method. The compatibility between the supramolecular adduct and pharmaceutical excipients starch, anhydrous lactose, magnesium stearate, and cellulose microcrystalline was studied employing thermoanalytical tools (TG-thermogravimetry/DTG-derivative thermogravimetry/HF-heat flow) and spectroscopic techniques (UATR-FTIR, PXRD). The compatibility study reveals that there are no interactions between the supramolecular adduct with starch, magnesium stearate, and cellulose microcrystalline, while incompatibility with anhydrous lactose is observed even under ambient conditions. The supramolecular adduct of RSP with RM-β-CD represents a valuable candidate for further research in developing new formulations with enhanced bioavailability and stability, and the results of this study allow a pertinent selection of three excipients that can be incorporated in solid dosage forms.

show abstract

Section: Resultsmentioning

confidence: 99%

Risperidone/Randomly Methylated β-Cyclodextrin Inclusion Complex—Compatibility Study with Pharmaceutical Excipients

et al. 2021

View full text Add to dashboard Cite

show abstract

“…1,8-cineole was determined using a UV spectrophotometric method described by Yin et al (2021), with slight modifications. Calibration curves were constructed for 1,8-cineole in n-hexane at different concentrations (w/v) and their absorbances detected at 250 nm using an Even UV/VIS spectrophotometer (Ionlab, Paraná, Brazil).…”

Section: Incorporation Efficiencymentioning

confidence: 99%

Cineole-containing nanoemulsion: Development, stability, and antibacterial activity

Lima

Silva

Nunes

et al. 2021

Chemistry and Physics of Lipids

View full text Add to dashboard Cite

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

show abstract

“…The spectrum of pure HP-β-CD showed two prominent absorption bands at 3414 cm −1 and 2929 cm −1 due to the stretching of the -OH and CH groups, respectively. In addition, it showed a peak at 1638 cm −1 attributable to the bending of the H-O-H group, a peak at 1157 cm −1 linked to the asymmetric stretching of the C-O-C glycosidic bridge, and two peaks corresponding to wavenumbers equal to 1082 and 1032 cm −1 due to the stretching of groups C-C and C-O, respectively [48]. The spectra of the physical mixture and the SAA process were more similar to the cyclodextrin one; however, some characteristic bands of curcumin were visible, highlighted with black vertical lines in the graph.…”

Section: Characterizationmentioning

confidence: 99%

Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization

Marco

Franco

2021

ChemEngineering

View full text Add to dashboard Cite

In this paper, composite systems containing curcumin (CUR) were prepared through supercritical-assisted atomization (SAA), using different carriers. Curcumin is particularly interesting in the pharmaceutical and nutraceutical fields for its antioxidant, antitumoral, and anti-inflammatory properties. However, its therapeutic effect on human health is restricted by its poor water solubility and low dissolution rate, limiting its absorption after its oral administration. To increase the dissolution rate and then the bioavailability of the active compound, CUR was coprecipitated with polymeric, i.e., polyvinylpyrrolidone (PVP) and dextran (DXT), and not polymeric, i.e., hydroxypropyl-β-cyclodextrin (HP-β-CD), carriers. The effects of some operating parameters, namely the concentration of solutes in solution and the active compound/carrier ratio, on the morphology and the particle size distribution of the powders were investigated. Submicrometric particles were produced with all the carriers. Under the best operating conditions, the mean diameters ± standard deviation were equal to 0.69 ± 0.20 μm, 0.40 ± 0.13 μm, and 0.81 ± 0.25 μm for PVP/CUR, DXT/CUR, and HP-β-CD/CUR, respectively. CUR dissolution rates from coprecipitated particles were significantly increased in the case of all the carriers. Therefore, the results are exciting from a pharmaceutical and nutraceutical point of view, to produce supplements containing curcumin, but assuring a high dissolution rate and bioavailability and, consequently, a more effective therapeutic effect.

show abstract

Optimization and characterization of 1,8-cineole/hydroxypropyl-β-cyclodextrin inclusion complex and study of its release kinetics

Cited by 59 publications

References 39 publications

Risperidone/Randomly Methylated β-Cyclodextrin Inclusion Complex—Compatibility Study with Pharmaceutical Excipients

Risperidone/Randomly Methylated β-Cyclodextrin Inclusion Complex—Compatibility Study with Pharmaceutical Excipients

Cineole-containing nanoemulsion: Development, stability, and antibacterial activity

Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization

Contact Info

Product

Resources

About