Cineole-containing nanoemulsion: Development, stability, and antibacterial activity

Abstract

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Development and in vitro cytotoxicity assessment of nanoemulsified lawsone

“…formulations indicating enhanced physical stability of these nanoscale colloidal emulsions (Gupta et al 2016;Lima et al 2021;Marhamati et al 2021;Ravera et al 2021). Such finding could be explained by a better packing of HCO-40 and SMO or HCO-40 and SIS at oil-water interfaces leading to a higher interfacial surfactant load and consequently optimum curvature and lower interfacial tension.…”

“…However, these methods require substantial energy input density to form small droplets, yet most mechanical energy generated may be dissipated as heat. On the other hand, low-energy or thermodynamic methods rely on the spontaneous generation of nanodroplets simply by changing environmental conditions (e.g., temperature) or some formulation parameters, such as concentration and type of surfactant and/or oil, and oil-water ratio (Guo et al 2020;Gupta et al 2016;Helgeson 2016;Lima et al 2021;Meng et al 2021;Panigrahi et al 2019). The main low-energy methods of nanoemulsion formation include phase inversion composition, phase inversion temperature, emulsion phase inversion, and spontaneous emulsification (Komaiko and McClements 2016).…”

Determination of orally administered 1,8-Cineol in nasal polyp tissues from chronic rhinosinusitis patients using gas chromatography: mass spectrometry

“…The present study revealed new insights into the distribution of 1,8-Cineol in the human body after oral administration and hint to a direct anti-inflammatory effect of 1,8-Cineol on site in nasal polyps of CRSwNP patients. The bioactive effects of 1,8-Cineol are known to be limited due to its low aqueous solubility and stability 33 . Different well-known 1,8-Cineol containing medications are applied orally as enteric coated capsules and evolve their curative effects after their passage through the stomach within the small intestine.…”

Carvacrol-Loaded Nanoemulsion Promotes Tocolytic and Anti-Dysmenorrhea Effects in Rodents

“…Ringer Locke's nutrient solution (154 mM NaCl, 5.63 mM KCl, 2.16 mM CaCl 2 .2H 2 O, 2.10 mM MgCl 2 , 5.55 mM glucose, 5.95 mM NaHCO 3 ) was used in the contraction and relaxation experiments. NanoCARV was composed of carvacrol incorporated into a stable nanometric formulation (1.5 g of medium-chain surfactant, 2 g of Tween 80, and 16 g of water for each 20 mL solution) [9]. The reference reagents used carvacrol, 4-aminopyridine (4-AP), carbachol (CCh), glibenclamide (GLI), Nω-nitro-L-arginine methyl ester (L-NAME), 1H- [1,2,4] oxadiazole [4,3-A] quinoxaline-1-ON (ODQ), propranolol (PRO), and tetraethylammonium (TEA) which were purchased from Sigma-Aldrich ® (St. Louis, MO, USA); Synth ® glucose (Diadema, SP, Brazil); sodium hydroxide and sodium chloride from Proquímios ® (Rio de Janeiro, Brazil); mefenamic acid from Germed Farmacêutica Ltda ® (São Paulo, Brazil); calcium chloride, sodium phosphate, and sodium bicarbonate from ISOFAR ® (Rio de Janeiro, Brazil); cesium chloride (CsCl) from CRQ ® ; potassium chloride from Dinâmica ® (Diadema, SP, Brazil); KabiPac ® sterile 0.9% sodium chloride; Cremophor EL from Fluka BioChemika ® (Germany); and aminophylline (AMN) from Farmace ® (Barbalha, CE, Brazil).…”