Optimising cell temperature and dispersion field strength for the screening for putrescine and cadaverine with thermal desorption-gas chromatography–differential mobility spectrometry

Awan, Muhammad Ali; Fleet, Ian A.; Thomas, C. L. Paul

doi:10.1016/j.aca.2008.01.083

Cited by 24 publications

(17 citation statements)

References 21 publications

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“…Biogenic amines are usually determined by thin layer chromatography (TLC) [6,7], capillary electrophoresis (CE) [8][9][10], gas chromatography (GC) [11,12] and liquid chromatography (LC) with ultra-violet (UV) or fluorescence detection [13][14][15][16][17][18][19][20][21][22][23]25]. Among these methods, LC is the most popular and frequently used for the separation and quantification of biogenic amines.…”

Section: Introductionmentioning

confidence: 99%

LC Determination of Trace Biogenic Amines in Foods Samples with Fluorescence Detection and MS Identification

You

Sun

et al. 2011

Chromatographia

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A pre-column derivatization method for the simple, sensitive determination of biogenic amines using 10-ethyl-acridine-3-sulfonyl chloride (EASC) as labeling reagent with fluorescence detection and mass spectrometry (MS) identification has been developed. After pre-column derivatization, the labeled biogenic amines were separated on a Hypersil BDS-C18 column by gradient elution. The derivatives showed an intense protonated molecular ion corresponding m/z [M ? H] ? in positive-ion mode. The collision-induced dissociation of protonated molecular ion formed specific fragment ions at m/z 196.5, m/z 222.7, m/z 224.4 and m/z 272.5, m/z 286.2. Satisfactory linear responses were observed at the concentration range of 0.02-10 lmol L -1 with coefficients of [0.9993. Detection limits obtained by the analysis of a derivatized standard containing 0.2 pmol of each biogenic amine, were from 20.22 to 109.2 fmol (at a signal-to-noise ratio of 3). The relative standard deviations of retention times and peak areas for each biogenic amine were \0.96 and 3.22%, respectively. Recoveries except for PUT were in the range of 96.7-103.6% for chicken sausage and 95.8-104.6% for pork sausage The established method for the determination of biogenic amines except for PUT from real samples was satisfactory.

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Section: Introductionmentioning

confidence: 99%

LC Determination of Trace Biogenic Amines in Foods Samples with Fluorescence Detection and MS Identification

You

Sun

et al. 2011

Chromatographia

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“…Biogenic amines are usually determined by separation techniques like thin layer chromatography (TLC) [22][23][24], capillary electrophoresis (CE) [17,[25][26][27][28][29], gas chromatography (GC) [30][31][32][33][34] and High performance liquid chromatography (HPLC) [21,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. HPLC is the technique most extensively used due to its high resolution, sensitivity, great versatility, and simple sample treatment.…”

Section: Introductionmentioning

confidence: 99%

Determination of biogenic amines in beer with pre-column derivatization by high performance liquid chromatography

Tang

Shi

Qian

et al. 2009

Journal of Chromatography B

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“…Data were generated from a central composite design 161 (CCD) with each of the 4 factors at 4 levels with replicates at five different 162 concentrations, see Table 2 [15]. The DMS parameters were optimised for 163 maximum sensitivity while maintaining "satisfactory" resolution between the ion 164 clusters generated within the 63 Ni ionisation source see Table 3, and Figures 2, 3 165 and 4.…”

Section: Experimental 93mentioning

confidence: 99%

A rapid and non-invasive method to determine toxic levels of alcohols and γ -hydroxybutyric acid in saliva samples by gas chromatography–differential mobility spectrometry

et al. 2016

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A polydimethylsiloxane oral sampler was used to extract methanol, ethanol, ethylene glycol, 1,3-propandiol and γ-hydroxybutyric acid from samples of human saliva obtained using a passive drool approach. The extracted compounds were recovered by thermal desorption, isolated by gas chromatography and detected with differential mobility spectrometry, operating with a programmed dispersion field. Complex signal behaviours were also observed that were consistent with hitherto unobserved fragmentation behaviours in differential mobility spectrometry. These yielded high-mobility fragments obscured within the envelope of the water-based reactant ion peak. Further, compensation field maxima shifts were also observed which were attributable to transport gas modification phenomena. Nevertheless, the responses obtained indicated that in vivo saliva sampling with thermal desorption gas chromatography may be used to provide a semi-quantitative diagnostic screen over the toxicity threshold concentration ranges of 100 mg dm−3 to 3 g dm−3. A candidate method suitable for use in low resource settings for the non-invasive screening of patients intoxicated by alcohols and volatile sedatives has been demonstrated.

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Optimising cell temperature and dispersion field strength for the screening for putrescine and cadaverine with thermal desorption-gas chromatography–differential mobility spectrometry

Cited by 24 publications

References 21 publications

LC Determination of Trace Biogenic Amines in Foods Samples with Fluorescence Detection and MS Identification

LC Determination of Trace Biogenic Amines in Foods Samples with Fluorescence Detection and MS Identification

Determination of biogenic amines in beer with pre-column derivatization by high performance liquid chromatography

A rapid and non-invasive method to determine toxic levels of alcohols and γ -hydroxybutyric acid in saliva samples by gas chromatography–differential mobility spectrometry

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