Optimisation of solvent replacement procedures according to economic and environmental criteria

Screening of organic solvents for bioprocesses using aqueous-organic two-phase systems

“…Regarding health and safety, some of the parameters are: toxicity & occupational exposure, auto-ignition temperature, boiling point, flash point, explosivity, reactivity and vapor pressure; these are particularly important considerations where a bioprocess is run in the presence of air or oxygen. Solvent selection guides are available, and some institutions and companies have also made studies to evaluate the hazards of the solvents and suggested alternative solvents which could substitute the most hazardous ones (Alfonsi et al, 2008; American Chemical Society (ACS), 2011; Elgue et al, 2006;Henderson et al, 2011;Prat et al, 2016Prat et al, , 2013.…”

“…The collection of these criteria forms the basis of a screening procedure in particular focused on biphasic systems in bioprocesses in order to narrow down the number of solvents to be tested experimentally. In this paper in contrast to previous publications (Elgue et al, 2006;Gani, 2006;Zhou et al, 2014), we deliberately restrict ourselves to bioprocesses using enzymes or microorganisms, to manufacture chemical products. We consider this screening procedure essential for the scientific community involved in the early stage development and research of new bioprocesses.…”

Evaluation of an intensified continuous heat-exchanger reactor for inherently safer characteristics

“…A specific computer simulation program has been written in parallel to the development of the reactor in order to predict the ''heat-exchanger/reactor'' behavior according to the operating conditions (Elgue et al, 2006). It integrates a precise description of the OPR geometry and models the hydrodynamic reaction phenomena as well as heat transfer in the device (Benaissa et al, 2008).…”

“…Indeed, fine chemicals industry is often confronted with the rapid change of the customer's demand and has to be able to switch quickly from one reaction to another. Through time these reactors were improved by numerous specific tools that were developed in order not only to increase their efficiency, optimize yield and selectivity (Zhang & Smith, 2004) but also to decrease the environmental impact by reducing the use of solvent (Elgue, Prat, Cabassud, & Cé zerac, 2006). However, these kind of reactors present an important technological limit: temperature control is not always sufficient and numerous case histories have demonstrated that most of the thermally initiated accidents took place in batch processes (Gustin, 2002).…”

Evaluation of Synthesis of Methyl 3-Chloro-5-(4,6-dimethoxypyrimidin- 2-ylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate Using Green Metrics

“…Some tools have been established and further developed to tolerate fewer argumentative processes [15][16][17][18][19][20][21][22][23], such as choosing of solvents considering environmental, health and safety feature as well as the life cycle assessment (LCA) and economic measure. Kralisch and co-workers [24,25] evaluated and optimized an approach considering ecological and economic aspects of the production of some reactants and solvents used in synthesis, workup, recycling and disposal.…”