Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin

Abstract

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.

FORMULASI KRIM EKSTRAK DAUN SIRIH CINA (Peperomia Pellucida L.) DENGAN VARIASI KONSENTRASI TRIETANOLAMIN DAN ASAM STEARAT

“…(Ain Thomas, Tungadi, & Manoppo, 2022). Daya sebar 3-5 cm dikatakan semistiff sedangkan 5-7 cm dikatakan semifluid (Lestari, Hajrin, & Hanifa, 2020).…”

Optimasi Formula Sediaan Lotion Ekstrak Daun Jambu Biji (Psidium guajava L.) Dengan Variasi Konsentrasi Setil Alkohol dan Gliserin

“…Tabel 1. Formula Sediaan Lotion dengan Variasi Konsentrasi Setil Alkohol dan Gliserin (Rowe et al, 2009;Mulyani et al, 2018) (Lestari, 2019). Optimasi formula sediaan lotion ekstrak daun jambu biji ini dilakukan dengan menggunakan metode Simplex Lattice Design dan dianalisis menggunakan software Design Expert versi 11 dengan cara menginput data hasil uji respon (pH, daya sebar dan daya lekat) 8 formula untuk mendapatkan formula optimum.…”

Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei)

“…Metode simplex lattice design dapat diterapkan pada optimasi berbagai campuran pelarut dalam ekstraksi metabolit sekunder dari bahan alam (Lestari et al, 2012;Harim, 2013;Setiawan, 2013;Anggasta, 2016). Metode ini juga dapat diaplikasikan dalam optimasi formula sediaan padat seperti tablet (Hadinugroho & Fudholi, 2011), sediaan cair seperti sirup (Juliantoni, 2014), maupun sediaan semisolid seperti krim, salep, dan gel (Lestari et al, 2020;Kholisatunnisa, 2017;Rosyadi, 2013).…”