Abstrak: Bay leaves (Syzygium polyanthum) are known to have antioxidant effects that can neutralize free radicals found in the skin. The objectives of this research are to formulate the ethanol extract of bay leaves into gel formulation and evaluate the physical properties of gel formulation. Ethanol extract of bay leaves was obtained through the maceration method with 70 % ethanol as a solvent. The thick ethanol extract of bay leaves was formulated into gel formulation with CMC – Na as a gelling agent, glycerin as a humectant, methyl paraben as a preservative, and aquadest as a solvent. After the freeze-thaw test was done, there was no change found in organoleptic but there were changes in pH, spreadability, and adhesion. The pH of gel preparation before being in storage was 5 and after being in storage was 6. In the spreadability, gel formulation spread 5,5 cm before being in the storage, and 5,1 cm after being in the storage. Gel adhesion has a sticky time of 8.35 seconds before in being storage and 8.45 seconds after being in storage.

High intensity of ultraviolet (UV) radiation causes several adverse effect such as erythema, sunburn, pigmentation, early senescence, and skin cancer. These effects can be prevented by using sun protection product. Wali (Brucea javanica L. Merr) is one of natural plants that contain phenol and flavonoid. These compounds are proven to have sunscreen effect. The purposes of this studies are to formulate and evaluate the effectivity of oil-in-water-type sunscreen cream using 1% ethanol extract of Wali seed. The sunscreen cream is developed by using a fusion method and the evaluation of the effectivity is conducted in vivo on the skin of mice (Mus musculus). The formulated sunscreen cream is then tested for its physical properties, including homogenity, pH, spreadability, adhesion, and stability. The effectivity of the formulated cream is also tested by observing the formation of erytema on the skin of mice (Mus musculus). Erythema appearing on the mouse skin is analyzed with ImageJ and SPSS v23 using the one way anova method. The results showed that the ethanol extract of Wali seeds could be formulated into sunscreen cream. Furthermore, the formulated cream was also able to protect the mice skin against the formation of erythema significantly compared to negative controls (p

Diabetes is a degenerative disease whose numbers continue to increase from year to year. Treatment with oral antidiabetic drugs can cause harmful side effects for patients. One of the plants that can be used for diabetes therapy is juwet (Syzygium cumini L.). Flavonoid compounds of juwet seed is easily oxidized and hydrolyzed in intestinal fluids with low absorption. This problem can be overcome by forming nanoparticle of juwet seed extract. The aims of this study was to obtain the formula for juwet seed nanoparticles. Nanoparticle of juwet seed extract made by ionic gelation method with chitosan and Na-TPP polymers which are varied. The formula optimization design in this study was determined using a simplex lattice design by 3 variations of materials based on the parameters %entrapment efficiency, %transmittant, particle size, polydisperse index, and zeta potential. The results showed that the yield of duwet seed extract was 7,44%. Juwet seed ethanolic extract contains 3.33 mg of quercetin per 1 g of extract. Based on the desirability value approach, the optimum formula was produced with an extract composition of 1.650 mL; chitosan 0.500 mL; and Na-TPP 0.010 mL can give optimal results with a desirability value of 0.772 which results in the criteria of 63.66% entrapment efficiency; 50.56% transmittant; 615,833nm particle size; 0.620 PDI; and zeta potential of +13.89 mV. Juwet seeds extract can be formulated into the form of nanoparticles. To get better parameters, it is advisable to optimize the mixing time and mixing speed in the ionic gelation method.

Glukomanan merupakan polisakarida yang tersusun oleh unit ?-D-glukosa dan  ?-D-mannosa yang terikat dengan gugus asetil melalui ikatan b-1,4 dan b-1,6 glikosida. Glukomanan terdapat pada dinding sel beberapa spesies tumbuhan terutama diekstraksi dari umbi genus amorphophallus spp. Secara komersial, pemanfaatan glukomanan sangat luas yaitu khususnya dalam industri farmasi digunakan sebagai bahan pengisi, pengikat tablet, pengental, gelling agent, film former, coating materials, emulsifier, stabilizer dan drug delivery system. Tujuan dari penelitian ini yaitu untuk menentukan kadar glukomanan yang diekstraksi dari umbi porang di Nusa Tenggara Barat. Penelitian yang dilakukan meliputi pembuatan tepung porang, ekstraksi glukomanan  menggunakan pelarut etanol 60% dan uji kuantitatif glukomanan dengan metode DNS (Dinitro Salisilic Acid) menggunakan instrumen spektrofotometer uv-vis. Hasil penelitian yang diperoleh yaitu rendemen tepung glukomanan sebesar 66,26% dengan kadar glukomanan hasil pemurnian sebesar 38,5312±0,5%.

Indonesian people have used herbal plants for generations to overcome health problems, but some people are still lacking in obtaining health services. Tenggareng hamlet, North Jenggik Village, Montong Gading Dstrict, East Lombok Regency, West Nusa Tenggara Province is one of the hamlets that has not optimized the yard as land for growing herbal plants. The yard house is suitable land for planting various types of plants. The purpose of this activities was to increase the knowledge of the community, especially about the cultivation and use of medicinal plants. The method used in this community services were lecturing and discussion method. Involving 42 participants. The results of community services are increasing people knowledge and skills related to the planting and utilization of herbal plants. This can be seen from the occurrence of interactive discussions. In conclusion, by conducting socialization and utilization of Family Medicinal Plants can increase public understanding to optimize Family Medicinal Plants.

Daun jambu biji (Psidium guajava L.) mengandung senyawa flavonoid yang berpotensi sebagai antioksidan yang dapat mencegah terjadinya kerusakan kulit karena radikal bebas sehingga produk kosmetik sediaan topikal dengan zat aktif ekstrak daun jambu biji perlu dikembangkan. Tujuan dilakukannya penelitian ini untuk menentukan formula optimum sediaan lotion ekstrak daun jambu biji (Psidium guajava L.) dengan variasi setil alkohol dan gliserin serta menentukan sifat fisik formula optimumnya. Metode ekstraksi yang digunakan yaitu maserasi dengan pelarut etanol 96%. Nilai rendemen yang diperoleh yaitu 17,64%. Hasil skrining flavonoid menunjukkan hasil positif yang ditandai dengan terjadinya perubahan warna larutan menjadi merah. Optimasi formula dilakukan dengan metode Simplex Lattice Design yang diolah menggunakan software Design Expert dan sediaan lotion diformulasi dengan meleburkan bahan fase minyak (asam stearat, setil alkohol, propil paraben) dan fase air (trietanolamin, gliserin, metil paraben, aquades) secara terpisah pada suhu 70-75oC kemudian disatukan dan diaduk hingga homogen. Dari software tersebut diperoleh formula optimum dengan konsentrasi setil alkohol dan gliserin masing-masing sebesar 3,93% dan 13,07%. Hasil evaluasi sifat fisik formula optimum yaitu memilki warna hijau kecoklatan, bau khas daun jambu biji, konsistensi yang kental dan pH 7,942, daya sebar 6,350 cm dan daya lekat 0,975 detik.

Senggigi village community has limitations in obtaining information about health, one of which is DAGUSIBU. DAGUSIBU is a way to get, use, store and dispose of medicines properly. The aim of this socialization was to inform about DAGUSIBU to the community so that medicines can be used rationally. The method used in the socialization is the delivery of material and direct examples related to the use of medicines that require special methods. The participants were very enthusiastic to attend the socialization, as evidenced by the many questions related to DAGUSIBU raised. This socialization increased participant’s knowledge about DAGUSIBU, they understand how to get, use, store and dispose of medicines in the right way.

The ultraviolet radiation and skin water loss could damage the skin. Kemuning leaves (Murraya paniculata (L) Jack) as a source of anti-oxidants and Aloe vera leaves (Aloe vera Linn) can prevent this action. This study aims to formulate and evaluate lotion containing the Kemuning leaves and Aloe vera extract. The extract of Kemuning leaves was obtained by sonication using 70% ethanol solvent. Aloe vera juice was obtained by smoothing the aloe vera gel then filtered using clean gauze.  The kemuning leaves extract and aloe vera extract had formulated into lotion preparation. The physical properties of the lotion (homogeneity, type of emulsion, pH, spreadability, and adhesion) were determined. The organoleptic test showed that the color of the lotion was pale yellow with a smooth texture and had extract scent. The lotion was showed good homogeneity, spreadability 7.31 cm, pH 7, type oil in water and adhesion 45 seconds. The physical properties parameters of lotion preparations showed that the lotion preparations had fulfilled the requirements of good preparations.