This paper studies the orbital pursuit-evasion-defense problem with the continuous low thrust propulsion. A control strategy for the pursuer is proposed based on the fuzzy comprehensive evaluation and the differential game. First, the system is described by the Lawden's equations, and simplified by introducing the relative state variables and the zero effort miss (ZEM) variables. Then, the objective function of the pursuer is designed based on the fuzzy comprehensive evaluation, and the analytical necessary conditions for the optimal control strategy are presented. Finally, a hybrid method combining the multi-objective genetic algorithm and the multiple shooting method is proposed to obtain the solution of the orbital pursuit-evasion-defense problem. The simulation results show that the proposed control strategy can handle the orbital pursuit-evasion-defense problem effectively. Appl. Sci. 2019, 9, 3190 2 of 16 information game and presented the adaptive strategies for the pursuer and the evader. Ghosh et al. [17] developed a near-optimal feedback controller for the two-player pursuit-evasion games by using a new extremal-field approach. The above works were studied in the two-player pursuit-evasion game framework. However, in this framework, the evader can only perform maneuvers by itself to avoid threats. It is called self-defense, which disturbs the original mission of the evader and requires a large additional amount of fuel.To overcome this disadvantage, a defender is introduced in [18]. The role of the defender is intercepting the pursuer. In this way, the evader can perform its original mission without being disturbed. A hybrid method combined particle swarm optimization with a Newton-Interpolation algorithm was proposed to solve the orbital defense problem. However, because of the introduction of the defender, the pursuer must avoid the interception by the defender while capturing the evader [19], which makes the design of the pursuer's control strategy more complicated. In order to develop control strategies for pursuers, Liu et al. [19] proposed a distributed online mission plan algorithm for pursuers to access targets. However, these works on the orbital pursuit-evasion-defense game adopted the impulsive thrust, which suffers the drawback that the interception will fail when the target can perform evasive maneuvers [4].Compared with the impulse thrust, the continuous low thrust allows players to perform multiple, continuous maneuvers, which meets the requirements of the frequently orbital transfers in the game. When applying the continuous low thrust, the hypothesis about players' maneuverable is removed. It is closer to the actual situation of the orbital pursuit-evasion-defense game. Therefore, in this paper, the orbital pursuit-evasion-defense game model is constructed based on the continuous low thrust. Different from the model based on impulse thrust, the model based on continuous low thrust cannot adopt the Keplerian dynamics [20]. Its dynamic equations are based on the non-Keplerian motion. T...