Optimal Magnetic Field for Crossing Super-Para-Magnetic Nanoparticles through the Brain Blood Barrier: A Computational Approach

Pedram, Maysam Zamani; Shamloo, Amir; Alasty, Aria; Ghafar-Zadeh, Ebrahim

doi:10.3390/bios6020025

Cited by 44 publications

(18 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results reveal that dopamine binds preferentially to octahedral sites and that the linking bond is with covalent nature. Experimental data corroborate the results, and the agreement proves that the DFT simulations can serve as an appropriate supplemental approach to interpreting 57 Fe Mössbauer spectra of SPIONs.…”

Section: Experimental Results Of S Kumar Et Al Show a Different Stasupporting

confidence: 75%

See 1 more Smart Citation

Iron oxide nanoparticles – In vivo/in vitro biomedical applications and in silico studies

Nedyalkova

Donkova

Romanova

et al. 2017

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

The review presents a broad overview of the biomedical applications of surface functionalized iron oxide nanoparticles (IONPs) as magnetic resonance imaging (MRI) agents for sensitive and precise diagnosis tool and synergistic combination with other imaging modalities. Then, the recent progress in therapeutic applications, such as hyperthermia is discussed and the available toxicity data of magnetic nanoparticles concerning in vitro and in vivo biomedical applications are addressed. This review also presents the available computer models using molecular dynamics (MD), Monte Carlo (MC) and density functional theory (DFT), as a basis for a complete understanding of the behaviour and morphology of functionalized IONPs, for improving NPs surface design and expanding the potential applications in nanomedicine.

show abstract

Section: Experimental Results Of S Kumar Et Al Show a Different Stasupporting

confidence: 75%

“…Recently, M. Z. Pedram et al explored the magnetic field effect to deliver SPIONs through the blood-brain barrier using molecular dynamics simulations and CHARMM27 force field [57]. The solvent effects were also taken into account by using the TIP3P method for water.…”

Section: Computational Investigations Of Spionsmentioning

confidence: 99%

Iron oxide nanoparticles – In vivo/in vitro biomedical applications and in silico studies

Nedyalkova

Donkova

Romanova

et al. 2017

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

show abstract

“…The selected literature about magnetic targeting/delivery in the CNS was classified into seven main groups: reviews [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]; in silico modeling [ 22 , 23 , 24 , 25 ]; BBB crossing under Static Magnetic Field (SMF) influence [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]; Alternating Magnetic Field (AMF) applications for targeting/delivery [ 38 , 39 , 40 , 41 , 42 , 43 ]; magnetofection [ 44 , 45 , 46 , 47 , 48 , 49 ]; applications for CNS ...…”

Section: Resultsmentioning

confidence: 99%

“…Size, shape and coating can alter magnetic forces and resistance by orders of magnitude: exceedingly small particles experience an insufficient magnetic force and too big ones encounter too much resistance in the tissue [ 24 , 25 ]. In general, the field strength should be of the order of 200–700 mT with gradients of about 8–100 T/m, depending on the blood flow (rate ranging from 10 cm/s in arteries to 0.05 cm/s in capillaries) [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Magnetic Nanoparticles in the Central Nervous System: Targeting Principles, Applications and Safety Issues

et al. 2017

View full text Add to dashboard Cite

One of the most challenging goals in pharmacological research is overcoming the Blood Brain Barrier (BBB) to deliver drugs to the Central Nervous System (CNS). The use of physical means, such as steady and alternating magnetic fields to drive nanocarriers with proper magnetic characteristics may prove to be a useful strategy. The present review aims at providing an up-to-date picture of the applications of magnetic-driven nanotheranostics agents to the CNS. Although well consolidated on physical ground, some of the techniques described herein are still under investigation on in vitro or in silico models, while others have already entered in—or are close to—clinical validation. The review provides a concise overview of the physical principles underlying the behavior of magnetic nanoparticles (MNPs) interacting with an external magnetic field. Thereafter we describe the physiological pathways by which a substance can reach the brain from the bloodstream and then we focus on those MNP applications that aim at a nondestructive crossing of the BBB such as static magnetic fields to facilitate the passage of drugs and alternating magnetic fields to increment BBB permeability by magnetic heating. In conclusion, we briefly cite the most notable biomedical applications of MNPs and some relevant remarks about their safety and potential toxicity.

show abstract

“…Magnetic nanoparticles (MNPs) were notably highlighted [ 24 ] because of their intrinsic magnetic properties and remain very useful tools for non-invasive MRI. In addition, some MNPs have shown potential properties to overcome certain biological and physical barriers, such as the BBB [ 25 ], and have proved their usefulness with tissue repair and hyperthermia properties [ 26 ]. MNPs gather superparamagnetic iron oxide nanoparticles (SPIONS), NPs with a metallic core (cobalt, zinc, nickel …), and other nanoparticles coated with magnetic material (silica NPs coated by gadolinium chelates or with iron …) [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review

et al. 2018

View full text Add to dashboard Cite

Magnetic nanoparticles (MNPs) have great potential in biomedical and clinical applications because of their many unique properties. This contribution provides an overview of the MNPs mainly used in the field of amyloid diseases. The first part discusses their use in understanding the amyloid mechanisms of fibrillation, with emphasis on their ability to control aggregation of amyloidogenic proteins. The second part deals with the functionalization by various moieties of numerous MNPs’ surfaces (molecules, peptides, antibody fragments, or whole antibodies of MNPs) for the detection and the quantification of amyloid aggregates. The last part of this review focuses on the use of MNPs for magnetic-resonance-based amyloid imaging in biomedical fields, with particular attention to the application of gadolinium-based paramagnetic nanoparticles (AGuIX), which have been recently developed. Biocompatible AGuIX nanoparticles show favorable characteristics for in vivo use, such as nanometric and straightforward functionalization. Their properties have enabled their application in MRI. Here, we report that AGuIX nanoparticles grafted with the Pittsburgh compound B can actively target amyloid aggregates in the brain, beyond the blood–brain barrier, and remain the first step in observing amyloid plaques in a mouse model of Alzheimer’s disease.

show abstract

Optimal Magnetic Field for Crossing Super-Para-Magnetic Nanoparticles through the Brain Blood Barrier: A Computational Approach

Cited by 44 publications

References 34 publications

Iron oxide nanoparticles – In vivo/in vitro biomedical applications and in silico studies

Iron oxide nanoparticles – In vivo/in vitro biomedical applications and in silico studies

Magnetic Nanoparticles in the Central Nervous System: Targeting Principles, Applications and Safety Issues

Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review

Contact Info

Product

Resources

About