In the U.S., emphasis has shifted towards improved pork quality and has resulted in greater use of Duroc-based terminal sires. Duroc sires have differences in ADG, ADFI, G:F, and carcass leanness compared to other sires. Therefore, our objective was to determine the standardized ileal digestible (SID) Lys estimates for Duroc-based sired finishing pigs. In Exp. 1, 2,124 pigs (DNA 600 × PIC 1050, initially 48.9 kg) were used with 24 to 27 pigs per pen and 16 pens per treatment. Corn-soybean meal-based diets were fed in 3 phases (49 to 59, 59 to 71, and 71 to 81 kg). Pens were randomly allotted to 1 of 5 treatments based as a percentage of PIC (2016) SID Lys estimates for gilts (85, 95, 103, 110, and 120%). Phase 1 diets were formulated to 0.90, 1.01, 1.09, 1.17 and 1.27%, phase 2 to 0.79, 0.87, 0.94, 1.03, and 1.10%, and phase 3 to 0.71, 0.78, 0.85, 0.92, and 0.99% SID Lys. Increasing SID Lys increased (linear, P < 0.001) ADG and Lys intake/kg of gain. A marginally significant improvement (quadratic, P = 0.071) in G:F was observed as SID Lys increased. Feed cost, feed cost/kg of gain, revenue (linear, P < 0.01) and income over feed cost (IOFC) increased (quadratic, P = 0.045) with increasing SID Lys. In Exp. 2, 2,099 pigs (DNA 600 × PIC 1050, initially 90.1 kg) were used with 24 to 27 pigs per pen and 20 pens per treatment. Corn-soybean meal-based diets were fed in 2 phases (90 to 106 and 106 to 136 kg). Pens were randomly allotted to 1 of 4 treatments based as a percentage of PIC (2016) SID Lys estimates for gilts (85, 93, 100, and 110%). Phase 1 diets were formulated to 0.65, 0.71, 0.77, and 0.84% and phase 2 to 0.60, 0.66, 0.71, and 0.78% SID Lys. Overall, increasing SID Lys increased (linear, P < 0.05) G:F, Lys intake/kg of gain, live weight and HCW, and increased (quadratic, P = 0.020) ADG. Feed cost (linear, P < 0.01), revenue, and IOFC increased (quadratic, P ≤ 0.053) with increasing SID Lys. In conclusion, the SID Lys estimate for growth and IOFC was 1.19% or 4.63 g SID Lys/Mcal of NE, 1.05% or 4.04 g SID Lys/Mcal of NE, and 0.94% or 3.58 g SID Lys/Mcal of NE for pigs weighing 49 to 59 kg, 59 to 71 kg, and 71 to 81 kg, respectively. The SID Lys estimate for late finishing pigs was 0.74 to 0.81% or 2.85 to 3.10 g SID Lys/Mcal of NE, and 0.69 to 0.75% or 2.61 to 2.84 g SID Lys/Mcal of NE, for 90 to 106 kg and 106 to 136 kg pigs, respectively. These data provide SID Lys estimates for current Duroc-sired genetic lines raised in a commercial environment.