Optimal design of a spectral readout type planar waveguide-mode sensor with a monolithic structure

Wang, Xiaomin; Fujimaki, Makoto; Kato, Takafumi; Nomura, Kohji; Awazu, Kunio; Ohki, Yoshimichi

doi:10.1364/oe.19.020205

Cited by 17 publications

(17 citation statements)

References 11 publications

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“…93 Various materials have been synthesized for surface modification and examined to suppress nonspecific adsorption of proteins, and self-assembled monolayers (SAM) of mercapto derivatives are reported to suppress nonspecific adsorption of proteins, effectively. [7][8][9][10] We were interested in application of close-packed monolayer formation on silica surface for fabrication of biosensing interface to examine potential of the waveguide-mode sensor [4][5][6] as a biosensor. We synthesized various triethoxysilane derivatives bearing oligoethylene glycol and succinimide ester moieties for surface modification of silica chip to fabricate close-packed monolayer surface, where oligoethylene glycol and succinimide ester moieties have the rolls, resistance against nonspecific adsorption of proteins and immobilization of functional proteins, respectively.…”

Section: Application Of Close-packed Monolayer On Silicamentioning

confidence: 99%

“…biosensing interface is depending on a sensing system, and it is considered that monolayer interface is appropriate to surface plasmon resonance (SPR), quartz crystal microbalance (QCM), and waveguide-mode systems [4][5][6] in view of sensitivity in detection. In the case of gold surface, it is well-known that mercapto derivatives form self-assembled monolayer with simple procedures.…”

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Fabrication of Biosensing Interface with Monolayers

Tanaka

Niwa

2020

ANAL. SCI.

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Surface modification is recognized as one of fundamental techniques to fabricate biosensing interface, and surface modification of carbon substrate (GC and HOPG) and silica with a close-packed monolayer was especially focused on in this review.In cases of carbon substrate, GC and HOPG, it was demonstrated that surface modification of carbon substrates with diazonium derivatives could afford a close-packed monolayer similar to the self-assembled monolayer (SAM) formation with mercapto derivatives. Similarly, potential of trialkoxysilanes to form a close-packed monolayer was evaluated, and a monolayer modification with a close-packed layer tended to occur under milder condition when the trialkoxysilanes had a longer alkyl chain. In these studies, we synthesized surface modification materials bearing ferrocene as a redox active moiety to explore features of the modified surfaces by an electrochemical method using cyclic voltammetry, where surface concentrations of immobilized molecule and blocking effect to obtain insight for density leading to a close-packed layer were available.According to those findings, fabrication of biosensing interface on the silica sensing chip of the waveguide-mode sensor was carried out using triethoxysilane derivatives bearing succinimide ester and oligoethylene glycol moieties to immobilize antibody and to suppress nonspecific adsorption of proteins, respectively. The results demonstrate that the waveguide-mode sensor powered by the biosensing interface fabricated with those triethoxysilane derivatives and antibody has potential to detect several tens ng/mL of biomarkers in human serum with unlabeled detection method.

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Section: Application Of Close-packed Monolayer On Silicamentioning

confidence: 99%

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confidence: 99%

Fabrication of Biosensing Interface with Monolayers

Tanaka

Niwa

2020

ANAL. SCI.

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“…If a spectrum is obtained by sweeping the wavelength, it would be possible to discard the two goniometers that were barriers to size reduction. [18] Figure 2 shows the simulation results of reflectivity changes before and after adsorption, assuming the adsorption of protein with 5 nm diameter (refractive index 1.45). The calculation was done with monocrystalline silicon layer thickness of 220 nm, silica waveguide layer thickness of 360 nm, prism material of silica, and at s-polarization.…”

Section: Development Of Portable Waveguide Mode Sensormentioning

confidence: 99%

Detection of influenza viruses with the waveguide mode sensor

Awazu

Fujimaki

Gopinath

et al. 2015

Synthesiology English edition

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(NA) with different antigenicity. In a new strains of influenza, mutation occurs in the HA and/or NA. Names such as type H1N1 influenza are given according to the type of HA and NA. In a new strain of influenza, new types of HA or NA appear among humans, and the antigenic drift and antigenic shift occur, or the influenza genes pass on from birds to humans. In past fact of research, it was found that the Spanish flu was caused by a hypovirulent H1N1 type derived from the avian flu.There are three reasons why a new strain of influenza is serious.(1) Since a new strain never existed before, no one has immunity. (2) It is highly infectious. It is thought that only an influenza virus that developed the ability for airborne infection causes a pandemic. (3) Since it is an unknown virus, vaccines cannot be made beforehand. Also, as an outstanding characteristic of the Spanish flu, young people developed serious conditions such as systemic infection, multiple organ failure, or a cytokine storm, which is an excessive vital reaction to viral infection. For example, the peak deaths of the Spanish flu occurred in people of ages 24-29. In Japan, there were newspaper headlines that said, "Most productive people were first to fall victims." The patients spread amongst the most productive people that supported society, and they died and paralyzed the social functions. According to the estimates by the Ministry of Health, Labour and Welfare, [5] if a pandemic equivalent to the strength of the Spanish flu (2.0 % fatality) occurred, 640 thousand people may die. However, since a mutant virus of subtype H5N1 has 60 % fatality rate, there are estimates that greater damage

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“…(9)(10)(11)(12)(13)(14)(15) Waveguide-mode sensors using a planar waveguide, with single-crystalline Si (c-Si) and SiO 2 layers sequentially stacked on a silica glass substrate, have been developed. (5,(9)(10)(11) However, the waveguide-mode sensor chip fabricated using the silica glass substrate is expensive for commercial use. Inexpensive optical glass, such as borosilicate glass, is desirable for use as a substrate, but borosilicate glass has a drawback in that its refractive index is higher than that of silica glass.…”

Section: Introductionmentioning

confidence: 99%

Waveguide-mode Sensor Chip with Si/SiO2/SiOx Structure

Yasuura¹,

Ueno²,

Ashiba³

et al. 2020

Sensors and Materials

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A waveguide-mode sensor detects changes in the complex refractive index on the surface of a planar waveguide chip with high sensitivity. We developed a waveguide-mode sensor chip with the Si/SiO 2 structure. It was predicted from simulations that a third layer of high refractive index added to the outermost surface of the planar waveguide may improve the sensitivity of the waveguide-mode sensor. In this research, we designed and manufactured a borosilicate glass substrate chip with a Si/SiO 2 /SiO x structure via sputtering deposition, and we improved the sensitivity of the waveguide-mode sensor chip. The Si/SiO 2 /SiO x structure chip was approximately 1.5 times more sensitive to refractive index changes than the Si/SiO 2 structure chip.

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Optimal design of a spectral readout type planar waveguide-mode sensor with a monolithic structure

Cited by 17 publications

References 11 publications

Fabrication of Biosensing Interface with Monolayers

Fabrication of Biosensing Interface with Monolayers

Detection of influenza viruses with the waveguide mode sensor

Waveguide-mode Sensor Chip with Si/SiO2/SiOx Structure

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