Optimal Combinations of Systematic Sextant and Laterally Directed Biopsies for the Detection of Prostate Cancer

Gore, John L.; Shariat, Shahrokh F.; Miles, Brian J.; Kadmon, Dov; Jiang, Ning; Wheeler, Thomas M.; Slawin, Kevin M.

doi:10.1016/s0022-5347(05)66347-1

Cited by 204 publications

(66 citation statements)

References 18 publications

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“…As a matter of fact, even EPBx might miss up to 40% of PCas [13,14,15,16,17,18,19,20]. Additionally, about 10–20% of the PCas not found at initial PBx are located in the transition zone (TZ), that is, not sampled during the initial biopsy [21,22,23].…”

Section: Resultsmentioning

confidence: 99%

Prostate Saturation Biopsy following a First Negative Biopsy: State of the Art

et al. 2012

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Introduction: Saturation prostate biopsy (SPBx) has been initially introduced to improve prostate cancer (PCa) detection rate (DR) in the repeat setting. Nevertheless, the optimal number and the most appropriate location of the cores, together with the timing to perform a second PBx and the eventual modification of the PBx protocols according to the different clinical situations, are matters of debate. The aim of this review is to perform a critical analysis of the literature about the actual role of SPBx in the repeat setting. Materials and Methods: We performed a systematic review of the literature since 1995 up to 2011. Electronic searches were limited to the English language, using the MEDLINE database. The key words ‘saturation prostate biopsy’ and ‘repeated prostate biopsy’ were used. Results: SPBx improves PCa DR if clinical suspicion persists after previous biopsy with negative findings and provides an accurate prediction of prostate tumor volume and grade, even if the issue about the number and locations of the cores is still a matter of debate. Conclusions: At present, SPBx seems to be really necessary in men with persistent suspicion of PCa after negative initial biopsy and probably in patients with a multifocal high-grade prostatic intraepithelial neoplasia or atypical small acinar proliferation. In the remaining situations, adopting an individualized scheme is preferable.

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Section: Resultsmentioning

confidence: 99%

Prostate Saturation Biopsy following a First Negative Biopsy: State of the Art

et al. 2012

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“…In addition, 2 transition zone biopsies were performed on each patient. The biopsy strategy used were those previously described [7].…”

Section: Methodsmentioning

confidence: 99%

Safety and detailed patterns of morbidity of transrectal ultrasound guided needle biopsy of prostate in a urologist-led unit

et al. 2006

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“…The optimal pattern in their study was a 10-core strategy with biopsies at the lateral base, mid, and apex, along with mid-sagittal biopsies at the base and apex. The highest cancer detection rates were at the lateral base and apex; the lowest yield came from TZ biopsies [25].…”

Section: The Evolution From Sextant To Extended Core Biopsiesmentioning

confidence: 96%

“…The overall cancer detection rate was 42%, with the highest detection rates observed with lateral and apex prostate biopsies [24]. Gore et al [25] systematically evaluated 396 consecutive patients undergoing TRUSguided sextant biopsies and extended lateral core biopsies. The authors evaluated all permutations of biopsy patterns to identify the minimum number and pattern of biopsies that would maintain a 98% cancer detection rate.…”

Section: The Evolution From Sextant To Extended Core Biopsiesmentioning

confidence: 99%

Diagnostic accuracy of prostate needle biopsy

Donahue

Moul

2002

Curr Urol Rep

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The introduction of prostate-specific antigen screening has resulted in stage migration and an increased incidence of localized prostate cancer. In this era of increasing nonpalpable disease, it has become necessary to systematically sample the entire prostate gland. Transrectal ultrasound-guided prostate biopsy procedures have evolved greatly over the past decade from the original sextant biopsy. Technological advances, better understanding of zonal anatomy of the prostate, whole mount sectioning of radical prostatectomy specimens, and computer modeling of localized prostate cancers have all led to extended biopsy core protocols directed at the lateral zones of the gland. These have increased the diagnostic accuracy of needle biopsy and have become a standard regimen. However, it remains controversial how to proceed with repeat biopsy in the face of an initial benign diagnosis, and optimal biopsy strategy remains undefined. It is hoped that quantitative analysis of prostate biopsy histology may eventually provide some prognostic information to guide the patient and urologist in preoperative planning.

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Optimal Combinations of Systematic Sextant and Laterally Directed Biopsies for the Detection of Prostate Cancer

Cited by 204 publications

References 18 publications

Prostate Saturation Biopsy following a First Negative Biopsy: State of the Art

Prostate Saturation Biopsy following a First Negative Biopsy: State of the Art

Safety and detailed patterns of morbidity of transrectal ultrasound guided needle biopsy of prostate in a urologist-led unit

Diagnostic accuracy of prostate needle biopsy

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