Prostate Saturation Biopsy following a First Negative Biopsy: State of the Art

Maccagnano, Carmen; Gallina, Andrea; Roscigno, Marco; Raber, Marco; Capitanio, Umberto; Saccà, Antonino; Pellucchi, Federico; Suardi, Nazareno; Abdollah, Firas; Montorsi, Francesco; Rigatti, Patrìzio; Scattoni, Vincenzo

doi:10.1159/000339521

Cited by 29 publications

(11 citation statements)

References 147 publications

(121 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[15] An ideal re-biopsy chart must be in compliance with clinical characteristics of the patient and should be considered for all patients whose first biopsies were received as ASAP or HGPIN. [16] Because pathologies such as ASAP or HGPIN were excluded in our study, the saturation biopsy was performed on the basis of TRUS results only. Seventy two of our patients (80%) found the probe introduction disturbing.…”

Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of the effects of periprostatic local anesthesia on recurrent prostate biopsy

Akdeniz

Akdeniz²,

Bolat³

et al. 2017

Agri

View full text Add to dashboard Cite

SummaryObjectives: The aim of the study was investigate the pain palliation effect of 2% dose of lidocaine on the periprostatic nerve block in prostate biopsy patients. Methods: Extended (12 cores) and saturation (22 cores) biopsy patients were included. The patients were separated into three groups: extended biopsy patients (Group I), saturation biopsy patients (Group II), and control group patients undergoing a biopsy procedure for the first time (Group III). All patients received 2% lidocaine (10 mL) on both the seminal vesicular junction and apex of the prostate with transrectal ultrasonography guidance. Following the procedure, the pain levels of patients were assessed using a 10-cm linear Visual Analog Scale (VAS). Results: Following the procedure, the VAS values of each group were 2.96±1.06, 3.2±1.47, and 2.93±0.94, respectively (p>0.05). While the highest pain score was seen in the saturation group patients (II), the lowest pain level was seen in the control biopsy group (III). However, no statistical di erence was observed among the groups. Conclusion: Herein, we observed that a local injection using 2% lidocaine was effective as local anesthetic in recurrent prostate biopsies. In addition, it was found that the pain level increases as the number of cores taken in recurrent prostate biopsies increases; however, this has not been established statistically.Keywords: Lidocaine; periprostatic local anesthesia; recurrent prostate biopsy. ÖzetAmaç: Çalışmamızda daha önce prostat biyopsisi deneyimi yaşayan ve yaşamayan hastalarda %25 lidokain ile yapılan periprostatik sinir bloğunun ağrı palyasyonu açısından etkisi retrospektif olarak araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmamıza genişletilmiş (12 kor) ve satürasyon (22 kor) biyopsisi yapılan hastalar alındı. Hastalar, genişle-tilmiş biyopsi yapılan hastalar (Grup I), satürasyon biyopsisi yapılan hastalar (Grup II) ve ilk defa biyopsi yapılacak kontrol grubu hastalar (Grup III) olmak üzere 3 gruba ayrıldı. Tüm hastalara 10cc %2 lidokain transrektal ultrasonografi (TRUSG) eşliğinde prostatın her iki seminal veziküler bileşkesine ve apeksine uygulandı. İşlem sonrası hastaların ağrı düzeyleri 10 cm'lik lineer Vizüel Analog Skala (VAS) aracılığıyla değerlendirildi. Bulgular: İşlem sonrası grupların VAS değerleri sırasıyla 2.96±1.06, 3.2±1.47 ve 2.93± 0.94 olarak bulundu (p>0.05). Sayısal olarak en yüksek ağrı skoru satürasyon grubu hastalarında bulunurken en düşük ağrı düzeyi genişletilmiş biyopsi yapılan grupta bulundu. Ancak gruplar arasında istatistiksel olarak bir fark izlenmedi. Sonuç: Çalışmamızda %2 lidokain kullanılarak yapılan periprostatik lokal anestezi enjeksiyonu tekrarlayan prostat biyopsilerinde etkili bir lokal anestezi sağladığı görülmüştür. Ayrıca tekrarlayan prostat biyopsilerinde alınan kor sayısı arttıkça ağrı düzeyinin arttığı bulunmuştur ancak bu durum istatistiksel olarak ortaya konulamamıştır.

show abstract

Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of the effects of periprostatic local anesthesia on recurrent prostate biopsy

Akdeniz

Akdeniz²,

Bolat³

et al. 2017

Agri

View full text Add to dashboard Cite

show abstract

“…The National Comprehensive Cancer Network (NCCN) guidelines state that a saturation biopsy may be considered in patients with two negative extended biopsies but with persistently rising PSA levels. Thus, saturation repeat biopsy seems to be necessary in men with persistent suspicion of prostate cancer after negative initial biopsy (11). Several studies have demonstrated that saturation biopsy techniques intended to greatly increase the number of sampling cores; thus, varying the distribution of biopsy sites may provide a higher cancer detection rate.…”

Section: Discussionmentioning

confidence: 99%

Comparison Between a Combined Transrectal and Transperineal Approach and a Transrectal Approach for Prostate Rebiopsy

Shida

Hakariya

Takehara

et al. 2016

View full text Add to dashboard Cite

Abstract. Aim: To evaluate whether a combination method involving the transrectal (TR) and transperineal (TP)approach 1, 2, 3, 4 and 5 were 49.2% (551/1,119), 34.7% (75/216), 33.3% (20/60), 26.7% (4/15) Transrectal ultrasound (TRUS)-guided biopsy has been recognized as the standard method for confirming a prostate cancer diagnosis worldwide. The utility of magnetic resonance (MR)-guided biopsy has been indicated in recent reports (1, 2). We agree with the opinion, however, that discussion on TRUS biopsy is still important due to its cost and equipment. In short, we think that MR-guided biopsy is often difficult in developing countries. After the initial introduction of the sextant prostate biopsy technique proposed by Hodge (3), the TRUS-guided biopsy technique has evolved with the introduction of extended 10-to 12-core biopsy and, subsequently, to over 20-core saturation biopsy strategies to minimize the sampling error and improve the accuracy of prostate cancer detection (4). However, it is well-recognized that even the standard 12-core TRUS-guided biopsy can miss up to 30% of cancers (5). TRUS-guided biopsy predominantly targets the lateral and posterior peripheral gland and can miss anteriorly located cancers. Therefore, several studies have focused on methods for anterior and apical biopsies.Transperineal (TP) biopsy of the prostate is an alternative approach that is less frequently performed. Kakehi et al. (6) reviewed 212,065 biopsies carried out at 548 institutions during the period between 2004 and 2006 in Japan. Of the 212,065 biopsies, 76% were carried out using the transrectal (TR) approach, 23% using the TP approach and only 1% using the combined methods of TR and TP (TR+TP). Ong et al. (7) reported that TP biopsy accounted for <0.5% of all prostate biopsies performed in Australia in 2007. However, there has been increasing interest in TP biopsy in recent 4685This article is freely accessible online.

show abstract

“…To improve the cancer detection rate in repeat biopsies, the recommendation is to collect an increased number of cores up to saturation biopsy [15,16,17]. Since a limited number of cores might not decrease the chance of obtaining the small foci and it was desirable to avoid adverse effects, in the present study the biopsies were performed via the perineal route, collecting ≥12 biopsy cores, depending on prostate volume [18].…”

Section: Discussionmentioning

confidence: 99%

Management of Men with a Suspicion of Prostate Cancer after Negative Initial Prostate Biopsy Results

et al. 2014

View full text Add to dashboard Cite

Introduction: For men with elevated prostate-specific antigen (PSA), appropriate management after negative prostate biopsy remains controversial. After determining PSA kinetics, subsequent follow-up was considered. Patients and Methods: A total of 115 cases with negative repeat biopsy were followed by evaluating PSA kinetics and ratio of percent free PSA (F/T) and by performing second repeat biopsy. Results: Eighteen cancer cases were diagnosed. Shorter PSA doubling times and faster velocities were found in cancer cases compared with cases without cancer. We observed a clear decrease in F/T among cancer cases. Conclusions: To avoid unnecessary repeat biopsies, cases with a suspicion of cancer after negative biopsy can be divided into two groups: one that requires additional biopsies and one with an average change in PSA of <1 ng/ml/year and no change in F/T, which is recommended for surveillance as stable disease without biopsy over a specified time period.

show abstract

Prostate Saturation Biopsy following a First Negative Biopsy: State of the Art

Cited by 29 publications

References 147 publications

Retrospective evaluation of the effects of periprostatic local anesthesia on recurrent prostate biopsy

Retrospective evaluation of the effects of periprostatic local anesthesia on recurrent prostate biopsy

Comparison Between a Combined Transrectal and Transperineal Approach and a Transrectal Approach for Prostate Rebiopsy

Management of Men with a Suspicion of Prostate Cancer after Negative Initial Prostate Biopsy Results

Contact Info

Product

Resources

About