Optically active two-dimensional MoS2-based nanohybrids for various biosensing applications: A comprehensive review

Ghosh, Sandip; Yang, Chia-Jung; Lai, Jui-Yang

doi:10.1016/j.bios.2023.115861

Biosensors and Bioelectronics

2024

DOI: 10.1016/j.bios.2023.115861

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Optically active two-dimensional MoS2-based nanohybrids for various biosensing applications: A comprehensive review

Sandip Ghosh,

Chia-Jung Yang,

Jui-Yang Lai

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2024

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Cited by 2 publications

References 111 publications

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Two‐Stage Mixed‐Dye‐Based Isothermal Amplification with Ribonuclease‐Cleavable Enhanced Probes for Dual‐Visualization Detection of SARS‐CoV‐2 Variants of Interest

Ding,

Wang,

Gui

et al. 2024

Advanced Science

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Rapid and visual detection of SARS‐CoV‐2 variants is vital for timely assessment of variant transmission in resource‐limited settings. Here, a closed‐tube, two‐stage, mixed‐dye‐based isothermal amplification method with ribonuclease‐cleavable enhanced probes (REP), termed REP‐TMAP, for dual‐visualization detection of SARS‐CoV‐2 variants including JN.1, BA.2, BA.4/5, and Delta is introduced. The first stage of REP‐TMAP is reverse transcription recombinase polymerase amplification and the second stage is dual‐visualization detection synergistically mediated by the REP and the mixed dyes of cresol red and hydroxy naphthol blue. In REP‐TMAP reaction, the color change under ambient light indicates SARS‐CoV‐2 infection, while the fluorescence change under blue light excitation specifies variant type. On detecting transcribed RNA of SARS‐CoV‐2 spike gene, this assay is rapid (within 40 min), highly sensitive (10–200 copies per reaction), and highly specific (identification of single‐base mutations). Furthermore, the assay has been clinically validated to accurately detect JN.1, BA.2, and BA.4/5 variants from 102 human oropharyngeal swabs. The proposed assay therefore holds great potentials to provide a rapid, dual‐visualization, sensitive, specific, point‐of‐care detection of SARS‐CoV‐2 variants and beyond.

show abstract

Two‐Stage Mixed‐Dye‐Based Isothermal Amplification with Ribonuclease‐Cleavable Enhanced Probes for Dual‐Visualization Detection of SARS‐CoV‐2 Variants of Interest

Ding,

Wang,

Gui

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

An insight into the dual role of MoS2-based nanocarriers in anticancer drug delivery and therapy

Ghosh,

Lai

2024

Acta Biomaterialia

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Optically active two-dimensional MoS2-based nanohybrids for various biosensing applications: A comprehensive review

Cited by 2 publications

References 111 publications

Two‐Stage Mixed‐Dye‐Based Isothermal Amplification with Ribonuclease‐Cleavable Enhanced Probes for Dual‐Visualization Detection of SARS‐CoV‐2 Variants of Interest

Two‐Stage Mixed‐Dye‐Based Isothermal Amplification with Ribonuclease‐Cleavable Enhanced Probes for Dual‐Visualization Detection of SARS‐CoV‐2 Variants of Interest

An insight into the dual role of MoS2-based nanocarriers in anticancer drug delivery and therapy

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