Optically Active Arthropod Repellents for Use Against Disease Vectors

Klun, J. A.; Ma, Da; Gupta, Raj K.

doi:10.1603/0022-2585-37.1.182

Cited by 15 publications

(9 citation statements)

References 13 publications

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“…1). 67, 78, 79 Interestingly, the 1 S , 2 S stereoisomer (SS220) is the most effective isomer against mosquitoes 79. Some of the early synthesis work on derivatives of cyclic amines includes a study by Alexander and Beroza60 on repellency of aliphatic amides of cyclic amines (C4, C5 and C6).…”

Section: Structural Diversity Of Chemical Repellentsmentioning

confidence: 99%

Mosquito repellents: a review of chemical structure diversity and olfaction

2010

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Research on mosquito chemical repellents continues to advance, along with knowledge of mosquito olfaction and behavior, mosquito-host interactions and chemical structure. New tools and technologies have revealed information about insect olfactory mechanisms and processing, providing a more complex approach for the interpretation of how chemical repellents influence host-seeking and feeding behavior. Even with these advances, there is still a large amount of information contained in the early works on insect repellents. Many of the standard test methods and chemicals that are still used for evaluating active repellents were developed in the 1940s. These studies contain valuable references to the activity of different structural classes of chemicals, and serve as a guide to optimization of select compounds for insect repellency effects.

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Section: Structural Diversity Of Chemical Repellentsmentioning

confidence: 99%

Mosquito repellents: a review of chemical structure diversity and olfaction

2010

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“…Of these, 1,4-naphthoquinone has many substituted forms that occur in nature (such as vitamin K), and several piperidines (many of which are natural, such as coniine) were repellent . We have already seen that some piperidine compounds were comparable to DEET in providing protection from several species of Acarina and Diptera (Klun et al, 2000). The USDA study also evaluated extracts of neem, and only the ether soluble portions of the ethanol extract were repellent .…”

Section: Insect Repellents Of Natural Originmentioning

confidence: 98%

“…Currently, several other compounds of interest are being evlauated. AI3-37220, or l-(3-cyclohexen-l-yl-carbonyl)-2-methyl piperidine, C1C-4, or (2hydroxymethyl cyclohexyl) acetic acid lactone (Frances et al, 1998) and cyclohexen-l-yl carbonyl) piperidine (Klun et al, 2000, and references therein) have been reported to have activity similar to DEET against several important species of Diptera and Acarina. Permethrin is used in mosquito bed nets (Robert et al, 1991 ), and permethrin and cypermethrin have been shown to repel the Western subterranean termite, Recticiili/ermes hesperas (Rust and Smith, 1993).…”

Section: Synthetic Compoundsmentioning

confidence: 99%

Insect repellents of natural origin: catnip and osage orange

Peterson

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The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Photographs included in the original manuscript have been reproduced xerographically in this copy. Higher quality 6" x 9" black and white photographic prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order.

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“…Currently, several other compounds of interest are being evlauated. AI3-37220, or l-(3-cyclohexen-l-yl-carbonyl)-2-methyl piperidine, C1C-4, or (2-hydroxymethyl cyclohexyl) acetic acid lactone (Frances et al, 1998) and AI3-35765, or l-(3-cyclohexen-l-yl carbonyl) piperidine (Klun et al, 2000, and references therein) have been reported to have activity similar to DEET against several important species of Diptera and Acarina. Permethrin is used in mosquito bed nets (Robert et al, 1991 ), and permethrin and cypermethrin have been shown to repel the Western subterranean termite, Recticiili/ermes hesperas (Rust and Smith, 1993).…”

Section: Synthetic Compoundsmentioning

confidence: 99%

mentioning

confidence: 99%

Insect repellents of natural origin: catnip and osage orange

Peterson

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This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps.Photographs included in the original manuscript have been reproduced xerographically in this copy. Higher quality 6" x 9" black and white photographic prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order.ProQuest Information and Learning 300 North Zeeb Road, Ann Arbor, Ml 48106-1346 USA 800-521-0600 The studies presented here represent my efforts over the last several years to identify naturally occurring insect repellents. Two plants are reported here, catnip and the osage orange. The first study confirmed repellency of osage orange extracts to the maize weevil, but found that repellency to two components, osajin and pomiferin, was not significant. A second study evaluated the effects of catnip essential oil on German cockroaches. Extracts of the plant and isolated compounds were more repellent than diethyl-m-toluamide (DEET).One isomer of nepetalactone was more active than the other was. We determined that the chemoreceptors responsible for the repellent response were located on the antennae. A third study reexamined some of the activity we saw in osage orange extracts in the first study. We examined the essential oils of the fruit, and identified several sesquiterpene compounds. We tested the repellency of essential oil components to German cockroaches, and found several of them to be repellent. In the last study we examined the repellency of catnip and osage orange extracts to the yellow fever mosquito. We determined that catnip essential oil significantly reduced the number of insects near the treated area. CHAPTER 1. INTRODUCTION AND LITERATURE REVIEW Introduction The Importance of Insects in Human HealthMembers of five orders in the Class Insecta feed on the blood of vertebrates:Phthiraptera (chewing and sucking lice, separated by some authors into two separate orders, the Mallophaga and Anoplura, respectively, of which only the Anoplura takes blood), Hemiptera (true bugs), Diptera (true flies), Siphonaptera (fleas) and a few species of Lepidoptera (moths and butterflies). In addition, one order in th...

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Optically Active Arthropod Repellents for Use Against Disease Vectors

Cited by 15 publications

References 13 publications

Mosquito repellents: a review of chemical structure diversity and olfaction

Mosquito repellents: a review of chemical structure diversity and olfaction

Insect repellents of natural origin: catnip and osage orange

Insect repellents of natural origin: catnip and osage orange

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