Mosquito repellents: a review of chemical structure diversity and olfaction

Paluch, Gretchen; Bartholomay, Lyric C.; Coats, Joel R.

doi:10.1002/ps.1974

Cited by 80 publications

(61 citation statements)

References 107 publications

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“…Documented attempts of deterring hematophagous insects date back to antiquity. Among the earliest reports of repellent use are from Herodotus, a Greek historian [17]. His account of communities burning plants to prevent the aggregation of biting flies demonstrates the success of this strategy.…”

Section: A Brief History Of Repellentsmentioning

confidence: 99%

Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control

Norris

Coats

2017

IJERPH

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135

100

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Every year, approximately 700,000 people die from complications associated with etiologic disease agents transmitted by mosquitoes. While insecticide-based vector control strategies are important for the management of mosquito-borne diseases, insecticide-resistance and other logistical hurdles may lower the efficacy of this approach, especially in developing countries. Repellent technologies represent another fundamental aspect of preventing mosquito-borne disease transmission. Among these technologies, spatial repellents are promising alternatives to the currently utilized contact repellents and may significantly aid in the prevention of mosquito-borne disease if properly incorporated into integrated pest management approaches. As their deployment would not rely on prohibitively expensive or impractical novel accessory technologies and resources, they have potential utility in developing countries where the burden of mosquito-borne disease is most prevalent. This review aims to describe the history of various repellent technologies, highlight the potential of repellent technologies in preventing the spread of mosquito-borne disease, and discuss currently known mechanisms that confer resistance to current contact and spatial repellents, which may lead to the failures of these repellents. In the subsequent section, current and future research projects aimed at exploring long-lasting non-pyrethroid spatial repellent molecules along with new paradigms and rationale for their development will be discussed.

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Section: A Brief History Of Repellentsmentioning

confidence: 99%

Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control

Norris

Coats

2017

IJERPH

Self Cite

135

100

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“…A simultaneous activation of different receptor sites may account for the high repellent effect of the ternary blend. Electrophysiological and molecular approaches, in fact, showed that repellents interact with olfactory and gustatory receptors in mosquito modulating their function through multiple molecular mechanisms (Paluck et al 2010;Bohbot et al 2011;Dickens and Bohbot 2013). Moreover, all three aldehydes tested in this study are perceived by the peripheral olfactory system of adult S. granarius males and females (Germinara et al 2002).…”

Section: Discussionmentioning

confidence: 75%

Repellents effectively disrupt the olfactory orientation of Sitophilus granarius to wheat kernels

2015

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Sitophilus granarius (L.) (Coleoptera: Dryophthoridae) is one of the most important pests of stored cereals worldwide. Sustainable control means of this pest are urgently needed mainly owing to legislative limits to the commonly used fumigants and broad-spectrum contact insecticides. The effectiveness of one alcohol and seven aliphatic aldehydes, previously identified as repellents, to disrupt adult granary weevils orientation towards wheat grains were assessed in two-choice olfactometer bioassays. In the dose range tested, all compounds effectively reduced wheat grains attractiveness and inhibited the preferential orientation of adult weevils towards the host substrate. Moreover, at the highest doses the three aldehydes butanal, (E)-2-hexenal, and (E,E)-2,4-nonadienal, their binary (1:1) and the ternary (1:1:1) blends induced a significant preferential orientation of insects to the control, indicating actual repellence. Among all repellent stimuli, the ternary blend and the binary blends of butanal plus (E)-2-hexenal and (E)-2-hexenal plus (E,E)-2,4-nonadienal were the most effective. At certain doses, the observed insect response to these blends was more intense than that expected from individual compounds, demonstrating synergistic interactions between the blend components. Repellent aldehydes and their mixtures were effective in disrupting the olfactory orientation of adult granary weevil to a highly attractive oviposition and food substrate. Future development of proper formulations of these bioactive compounds is promising to set up semiochemical-based control means for this pest.

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“…Clearly the nepetalactone molecule has spurred new interest and efforts in development of natural, alternative repellents. A recent review of insect repellents has been published (19).…”

Section: Discussionmentioning

confidence: 99%

Catnip Essential Oil and Its Nepetalactone Isomers as Repellents for Mosquitoes

Peterson

Coats

2011

ACS Symposium Series

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The effect of catnip Nepeta cataria essential oil and two isomers of nepetalactone, the major components, on the distribution of Aedes aegypti (yellow fever mosquito) mosquitoes in a static-air olfactometer response was examined to determine their activity as spatial repellents. A glass cylinder was used as a choice-test chamber. The catnip (Nepeta cataria) essential oil, as well as the E,Z-and Z,E-isomers of nepetalactone were significantly repellent after application of one ml of 1% and 0.1% solution to filter paper (conc. of 157 and 15.7 µg/cm2). Diethyl-m-toluamide (DEET) a positive control was significantly repellent at 157 µg/cm2 in this assay. Both nepetalactone isomers and the catnip essential oil had excellent spatial repellency while DEET only exhibited spatial repellency at higher concentrations. The bioassay allowed for definition of and delineation between spatial and contact repellency. The effect of catnip Nepeta cataria essential oil and two isomers of nepetalactone, the major components, on the distribution of Aedes aegypti (yellow fever mosquito) mosquitoes in a static-air olfactometer response was examined to determine their activity as spatial repellents. A glass cylinder was used as a choice-test chamber. The catnip (Nepeta cataria) essential oil, as well as the E,Z-and Z,E-isomers of nepetalactone were significantly repellent after application of one ml of 1% and 0.1% solution to filter paper (conc. of 157 and 15.7 µg/cm 2 ). Diethyl-m-toluamide (DEET) a positive control was significantly repellent at 157 µg/cm 2 in this assay. Both nepetalactone isomers and the catnip essential oil had excellent spatial repellency while DEET only exhibited spatial repellency at higher concentrations. The bioassay allowed for definition of and delineation between spatial and contact repellency.

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Mosquito repellents: a review of chemical structure diversity and olfaction

Cited by 80 publications

References 107 publications

Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control

Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control

Repellents effectively disrupt the olfactory orientation of Sitophilus granarius to wheat kernels

Catnip Essential Oil and Its Nepetalactone Isomers as Repellents for Mosquitoes

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