Optical tweezer platform for the characterization of pH-triggered colloidal transformations in the oleic acid/water system

PEGylation of Phosphatidylglycerol/Docosahexaenoic Acid Hexosomes with d-α-Tocopheryl Succinate Poly(ethylene glycol)2000 Induces Morphological Transformation into Vesicles with Prolonged Circulation Times

“…This is consistent with our recent studies, and presumably arising from the presence of ionized carboxylic groups of DHA at relatively higher local concentrations at the DOPG–water interface. There are also different recent examples in the literature on pH-mediated structural transitions. ,,− For instance, it was reported on pH-mediated hexosome-cubosome colloidal transformation in nanodispersions stabilized with Pluronic F127 that can be used to enhance antifungal therapy . Notably in this study, PEGylation at pH 6.0 led to a dramatic increase in zeta potential, which we attribute to the steric shielding effect provided by nonionic PEG chains on the nanoparticle surface charge. , …”