Optical sensor arrays designed for guided manufacture of perfluorocarbon nanoemulsions with a non-synthetic stabilizer

Bardsley, R.E.; Gardner, Graeme; Tse, Hubert M.; Fraker, Christopher A.

doi:10.1016/j.actbio.2021.09.038

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…Lipid-based NPs may be classified into phospholipid and non-phospholipid vesicles. The former includes liposomes, transfersomes, ethosomes, and trans-ethosomes [7][8][9] while, the latter comprises solid lipid NPs [10], nanostructured lipid carriers [11], polymeric micelles [12,13], niosomes [14], nano-emulsions [15], and dendrimers [16]. The liposome has a structure comparable to the cell membrane, which has two phospholipid layers and is spherical in form.…”

Section: Introductionmentioning

confidence: 99%

Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells

et al. 2022

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6-Mercaptopurine (6-MP) is a well-known immunosuppressive medication with proven anti-proliferative activities. 6-MP possesses incomplete and highly variable oral absorption due to its poor water solubility, which might reduce its anti-cancer properties. To overcome these negative effects, we developed neutral and positively charged drug-loaded liposomal formulations utilizing the thin-film hydration technique. The prepared liposomal formulations were characterized for their size, polydispersity index (PDI), zeta potential, and entrapment efficiency. The average size of the prepared liposomes was between 574.67 ± 37.29 and 660.47 ± 44.32 nm. Positively charged liposomes (F1 and F3) exhibited a lower PDI than the corresponding neutrally charged ones (F2 and F4). Entrapment efficiency was higher in the neutral liposomes when compared to the charged formulation. F1 showed the lowest IC50 against HepG2, HCT116, and MCF-7 cancer cells. HepG2 cells treated with F1 showed the highest level of inhibition of cell proliferation with no evidence of apoptosis. Cell cycle analysis showed an increase in the G1/G0 and S phases, along with a decrease in the G2/M phases in the cell lines treated with drug loaded positively charged liposomes when compared to free positive liposomes, indicating arrest of cells in the S phase due to the stoppage of priming and DNA synthesis outside the mitotic phase. As a result, liposomes could be considered as an effective drug delivery system for treatment of a variety of cancers; they provide a chance that a nanoformulation of 6-MP will boost the cytotoxicity of the drug in a small pharmacological dose which provides a dosage advantage.

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Section: Introductionmentioning

confidence: 99%

Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells

et al. 2022

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“…Temperature may affect the turbidity from two aspects. One is the influence of temperature on the photoelectric components inside the turbidity sensor, including optical emitting and receiving electronic components [12,16]. The other is the effect of temperature on the distribution and movement of tiny particles in water.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Water Temperature on In-Line Turbidity Detection

Shi

Zhang

2022

Water

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Turbidity measurements are influenced by environmental factors such as water temperature. We designed experiments to study whether water temperature affects in-line turbidity detection and the potential influence mechanism. A turbidity meter installed in-line could self-record data, including the water temperature and turbidity values. From our experimental analysis, we verified the influence of water temperature on the in-line turbidity. Moreover, the temperature coefficient should not be obtained from the experiment directly because the intrinsic impact of in-line turbidity detection does not come from water temperature. Instead, the effect is derived from the optical components’ heat change. When the water temperature change is insignificant, the in-line turbidity deviation caused by the water temperature can be ignored. However, when the water temperature changes substantially, the in-line turbidity sensor should compensate for the temperature drift.

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A critical review of the novelties in the development of intravenous nanoemulsions

Czerniel,

Gostyńska,

Jańczak

et al. 2023

European Journal of Pharmaceutics and Biopharmaceutics

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Optical sensor arrays designed for guided manufacture of perfluorocarbon nanoemulsions with a non-synthetic stabilizer

Cited by 3 publications

References 56 publications

Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells

Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells

The Impact of Water Temperature on In-Line Turbidity Detection

A critical review of the novelties in the development of intravenous nanoemulsions

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