A critical review of the novelties in the development of intravenous nanoemulsions

Czerniel, Joanna; Gostyńska, Aleksandra; Jańczak, Julia; Stawny, Maciej

doi:10.1016/j.ejpb.2023.08.009

Cited by 4 publications

(2 citation statements)

References 134 publications

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“…Since such data allow for successful implementation and immediate practical application of the developed formulation [ 13 , 44 ]. Nevertheless, as shown in many other studies on intravenous lipid emulsion, the sterilization, and long-term stability studies are not always presented at such an early stage of the formulation development [ 45 ]. Despite those limitations, the presented results showed great potential for magnolol-loaded intravenous lipid emulsion and may contribute to changing the approach to treating IFALD and focusing on the natural bioactive compounds deficiency in parenteral nutrition-depended patients.…”

Section: Limitationsmentioning

confidence: 99%

The Development of Magnolol-Loaded Intravenous Emulsion with Low Hepatotoxic Potential

Gostyńska,

Czerniel,

Kuźmińska

et al. 2023

Pharmaceuticals

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Intestinal failure-associated liver disease (IFALD) is a severe liver injury occurring due to factors related to intestinal failure and parenteral nutrition administration. Different approaches are studied to reduce the risk or ameliorate the course of IFALD, including providing omega-3 fatty acids instead of soybean oil-based lipid emulsion or administering active compounds that exert a hepatoprotective effect. This study aimed to develop, optimize, and characterize magnolol-loaded intravenous lipid emulsion for parenteral nutrition. The preformulation studies allowed for chosen oils mixture of the highest capacity of magnolol solubilization. Then, magnolol-loaded SMOFlipid was developed using the passive incorporation method. The Box–Behnken design and response surface methodology were used to optimize the entrapment efficiency. The optimal formulation was subjected to short-term stress tests, and its effect on normal human liver cells and erythrocytes was determined using the MTT and hemolysis tests, respectively. The optimized magnolol-loaded SMOFlipid was characterized by the mean droplet diameter of 327.6 ± 2.9 nm with a polydispersity index of 0.12 ± 0.02 and zeta potential of −32.8 ± 1.2 mV. The entrapment efficiency of magnolol was above 98%, and pH and osmolality were sufficient for intravenous administration. The magnolol-loaded SMOFlipid samples showed a significantly lower toxic effect than bare SMOFlipid in the same concentration on THLE-2 cells, and revealed an acceptable hemolytic effect of 8.3%. The developed formulation was characterized by satisfactory stability. The in vitro studies showed the reduced cytotoxic effect of MAG-SMOF applied in high concentrations compared to bare SMOFlipid and the non-hemolytic effect on human blood cells. The magnolol-loaded SMOFlipid is promising for further development of hepatoprotective lipid emulsion for parenteral nutrition.

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Section: Limitationsmentioning

confidence: 99%

The Development of Magnolol-Loaded Intravenous Emulsion with Low Hepatotoxic Potential

Gostyńska,

Czerniel,

Kuźmińska

et al. 2023

Pharmaceuticals

Self Cite

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“…The oil droplets will mix with the water phase (Agustinisari et al, 2014). The nanoemulsion form was chosen because it can increase the physical stability of a bioactive component, prevent chemical damage and interaction with food ingredients, and be disseminated efficiently in water systems (Czerniel et al, 2023). The effectiveness of this preparation can be increased and maximized through the use of nanoemulsion technology (Qian et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion Formulation of Kepok Banana Peel Extract and Yellow Watermelon Peel as a Kidney Stone Removal

Diaz Habibah,

Ogan Amirudin Lutfi,

Thosimomia Tamimi

et al. 2023

ihj

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The kepok banana peel and yellow watermelon peel are still rarely appropriately used as medicine. The kepok banana peel and yellow watermelon peel contain flavonoids and potassium that function as kidney stone removers. This study aims to make a nanoemulsion formulation of kepok banana peel extract and yellow watermelon peel as a kidney stone remover. The preparation starts with extraction, testing the flavonoid content of the extract, testing the potassium content of the extract, making nanoemulsion using the homogenization method at a speed of 15,200 rpm, and analyzing the nanoemulsion formula that has been made. This study showed that the nanoemulsion extract contained flavonoids and potassium with a pH value of 7 and a viscosity value of 2.70 cP. The nanoemulsion of kepok banana peel and yellow watermelon peel extracts also has a size of 246.9 nm and a PDI of 0.618 with an oil-in-water (O/W) nanoemulsion type. The extracts of kepok banana peel and yellow watermelon peel in nanoemulsion preparation can be used as a medicine to remove kidney stones.

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Nano-carrier Systems for Berberine Delivery: A Literature Review of Nano-formulations and Their Applications

Mohammadzadeh,

Nourollahian,

Zirak

et al. 2024

Sustainable Landscape Planning and Natural Resources Management

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A critical review of the novelties in the development of intravenous nanoemulsions

Cited by 4 publications

References 134 publications

The Development of Magnolol-Loaded Intravenous Emulsion with Low Hepatotoxic Potential

The Development of Magnolol-Loaded Intravenous Emulsion with Low Hepatotoxic Potential

Nanoemulsion Formulation of Kepok Banana Peel Extract and Yellow Watermelon Peel as a Kidney Stone Removal

Nano-carrier Systems for Berberine Delivery: A Literature Review of Nano-formulations and Their Applications

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