In memory of Egbert Havinga, born 100 years ago Routes to create enantiomerically pure compounds starting from prochiral or racemic components are a principal issue in the discussion on the emergence of prebiotic chiral molecules. Such routes to single-handedness are also of paramount practical importance today, especially for economical highyielding processes to pharmaceutical compounds that often must be registered in enantiomerically pure form. [1] Louis Pasteur demonstrated that enantiomorphous crystals (a racemic conglomerate) of a tartrate salt could be separated manually.[2] Crystallization of a conglomerate is an attractive option to obtain enantiomerically pure materials, provided a better means of separation than manual crystal sorting is available. Resolution by crystallization is much more attractive if simultaneous racemization of the unwanted enantiomer occurs. This combination of crystallization and racemization in solution results in a so-called total spontaneous resolution, [3] for which enantiopure seeds are introduced into a clear supersaturated solution in which racemization takes place. These seeds grow further, resulting in an increasing amount of enantiopure solid material, until the solution is depleted of racemate. To reduce the nucleation rate of the undesired enantiomer, the supersaturation can be lowered by introducing many secondary nuclei of the desired enantiomer by stirring. [4,5] In principle, all chiral material that crystallizes can be converted into the desired enantiomer. The theoretical yield in enantiopure solid phase is thus 100 % and in practice only limited by solubility. To prevent the unwanted enantiomer from nucleating, however, the crystallization conditions, and in particular the temperature, need to be controlled well.The recent demonstration of a complete deracemization using crystallization with abrasive grinding under nearequilibrium conditions is a remarkably simple and much more reliable technique to reach an enantiomerically pure end state for these systems.[6] Recently we determined the rate-determining parameters for this deracemization process.[6d] In particular, we found that the deracemization time increases linearly with the amount of solids in the slurry. Furthermore, the time needed for the system to overcome the threshold of the autocatalytic process could be minimized by starting from an enantioenriched solid phase.[6c] Would it therefore be beneficial to start with a small amount of solids having a large enantiomeric excess (ee), and then gradually feed the slurry under isothermal conditions with racemic material? In this way, the solid phase can sustain a high ee, resulting in a high deracemization rate. Overall, this procedure should shorten the time required to reach an enantiopure solid phase.Although the gradual feeding can be realized mechanically, the target molecule can be alternatively synthesized in situ, making the practical execution very simple. To show the practical applicability, the non-steroidal anti-inflammatory drug (S)-naproxen i...