Gas antisolvent fractionation based optical resolution of ibuprofen with enantiopure phenylglycinol

Lőrincz, László; Tóth, Á.; Kondor, László; Kéri, Orsolya; Madarász, János; Varga, Erzsébet; Székely, Edit

doi:10.1016/j.jcou.2018.09.004

Cited by 4 publications

(4 citation statements)

References 47 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…phenylglycinol. 56 The process exhibited normal behavior without any anomalies, yielding diastereomeric excess values exceeding 99% in three consecutive stages, with a total yield of 0.71. In a single optical resolution step, the maximum diastereomeric excess value achieved was 70%, and under ideal conditions (maximal selectivity), the value of de was approximately 60%.…”

Section: Antisolvent Methodsmentioning

confidence: 93%

“…L} orincz and colleagues developed a gas antisolvent method for resolving IBP using enantiopure F I G U R E 5 Description of supercritical gas antisolvent instrument. Adapted from L} orincz et al 56 Copyright © the authors.…”

Section: Antisolvent Methodsmentioning

confidence: 99%

Section: Methods For Stereoselective Analysis Of Ibuprofenmentioning

confidence: 99%

“…Lőrincz and colleagues developed a gas antisolvent method for resolving IBP using enantiopure phenylglycinol 56 . The process exhibited normal behavior without any anomalies, yielding diastereomeric excess values exceeding 99% in three consecutive stages, with a total yield of 0.71.…”

Section: Methods For Stereoselective Analysis Of Ibuprofenmentioning

confidence: 99%

See 3 more Smart Citations

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

Vashistha,

Kumar,

Yadav

et al. 2024

Chirality

View full text Add to dashboard Cite

Ibuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti‐inflammatory drug (NSAID) comprising two enantiomers, (R)‐IBP and (S)‐IBP, collectively known as (RS)‐IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state‐of‐the‐art methods, including chromatographic techniques including high‐performance liquid chromatography, gas chromatography, liquid chromatography–tandem mass spectrometry, and some other techniques. This review addresses pharmacokinetics, pharmacology, and side effects of each enantiomer, ensuring safe drug usage. By consolidating diverse analytical methods and their applicability in different matrices, this review serves as a valuable resource for researchers, analysts, and practitioners in pharmaceutical analysis, pharmacology, and clinical studies.

show abstract

Section: Antisolvent Methodsmentioning

confidence: 93%

Section: Antisolvent Methodsmentioning

confidence: 99%