Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation

Bosschaart, Nienke; Mentink, Rosaline; Kok, Joke H.; Leeuwen, Ton G. van; Aalders, Maurice C. G.

doi:10.1117/1.3622629

Cited by 40 publications

(57 citation statements)

References 19 publications

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“…Pigmentation decreased as gestational age increased from 37 to 42 weeks (27). Further increases over postnatal days 25–75 were observed only in African American premature infants (28). Ultraviolet-induced pigmentation was very low for 6 – 24 month infants during their first summer but significantly higher a year later, suggesting darkening over the period (29).…”

Section: Discussionmentioning

confidence: 98%

Infant skin maturation: Preliminary outcomes for color and biomechanical properties

Visscher

Burkes

Adams

et al. 2017

Skin Research and Technology

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Background Newborn infant skin changes after birth but studies have focused on the epidermal barrier. Dermal properties are relevant for care, but literature on postnatal changes is sparse. We further characterized skin maturational changes in lightness, color and response to biomechanical stress. Methods Normal skin sites from subsets of participants in a trial on the progression and stage of infantile hemangiomas were retrospectively examined. Standardized photographs were analyzed as L*, a* and b* images. Biomechanics were measured with the Cutometer®. Results Color changed significantly with increasing age. Skin was darker and redder at 2.0versus 5.4, 8.5 and 12.8 months. Yellow color increased, with higher values at 12.8 versus 2.0, 3.5 and 5.4 months. Chest tissue was consistently more elastic than arm and face sites, with significantly higher elasticity for the youngest and oldest age groups. Biological elasticity, elastic recovery and total recovery were significantly greater for the oldest subjects. Viscoelasticity and elastic deformation were lower at 5.5 versus 8.8 and 17.6 months. Arm viscoelastic creep was highest at 2.8 months. Conclusion Skin maturation continues into year two. Increasing elasticity and decreasing viscoelasticity may reflect increased collagen structure/function. The findings have implications for prevention of skin injury associated with mechanical forces.

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Section: Discussionmentioning

confidence: 98%

Infant skin maturation: Preliminary outcomes for color and biomechanical properties

Visscher

Burkes

Adams

et al. 2017

Skin Research and Technology

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“…6, Appendix). Bosschaart et al 82 employed a diffusion approximation technique to their data collected from neonates, effectively applying a single value of absorption across the skin volume. Their data is in close agreement to Meglinski and Matcher's dermal absorption coefficients in the 530-to 600-nm range, but the contribution of melanin produces a relative increase in Bosschaart et al's values at shorter wavelengths.…”

Section: In Vivo Absorption Coefficientsmentioning

confidence: 99%

Optical properties of human skin

2012

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Abstract. A survey of the literature is presented that provides an analysis of the optical properties of human skin, with particular regard to their applications in medicine. Included is a description of the primary interactions of light with skin and how these are commonly estimated using radiative transfer theory (RTT). This is followed by analysis of measured RTT coefficients available in the literature. Orders of magnitude differences are found within published absorption and reduced-scattering coefficients. Causes for these discrepancies are discussed in detail, including contrasts between data acquired in vitro and in vivo. An analysis of the phase functions applied in skin optics, along with the remaining optical coefficients (anisotropy factors and refractive indices) is also included. The survey concludes that further work in the field is necessary to establish a definitive range of realistic coefficients for clinically normal skin.

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“…Spectroscopic instrumentation requires a calibration to account for wavelength-dependent factors, such as the output from the fiber and detector sensitivity. For some diffuse reflectance spectroscopy 1 techniques, a relative calibration of the reflectance is sufficient. For single fiber reflectance spectroscopy (SFR), however, the measured absolute reflectance R is related to the sample optical properties 2,3 E Q -T A R G E T ; t e m p : i n t r a l i n k -; e 0 0 1 ; 6 3 ; 2 2 7 R ¼ η limit · fðμ 0 s ; μ a ; γ; d fib Þ;…”

Section: Introductionmentioning

confidence: 99%

Single fiber reflectance spectroscopy calibration

et al. 2017

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Abstract. To accurately determine sample optical properties using single fiber reflectance spectroscopy (SFR), an absolute calibration of the reflectance is required. We investigated two SFR calibration methods, using a calibrated mirror and using the Fresnel reflection at the fiber tip as a reference. We compared these to commonly used calibration methods, using either Intralipid-20% in combination with Monte Carlo simulations or Spectralon as a reference. The Fresnel reflection method demonstrated the best reproducibility and yielded the most reliable result. We therefore recommend the Fresnel reflection method for the measured absolute reflectance calibration of SFR. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation

Cited by 40 publications

References 19 publications

Infant skin maturation: Preliminary outcomes for color and biomechanical properties

Infant skin maturation: Preliminary outcomes for color and biomechanical properties

Optical properties of human skin

Single fiber reflectance spectroscopy calibration

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