Optical profile: A key determinant of antibacterial efficacy of photodynamic therapy in dentistry

Su, Chuan‐Tsung; Chen, Chun‐Ju; Chen, Chung‐Ming; Chen, Chun‐Cheng; Ma, Shih‐Hsin; Wu, Jih‐Huah

doi:10.1016/j.pdpdt.2021.102461

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…In cases where A. actinomycetemcomitans forms a biofilm, Etemadi et al 22 . used a diode laser with a 635 nm wavelength to activate 125 μg/mL phytocyanin decreased by 40.07%, while Su et al 23 . found PDT could reach an eradication of 98%.…”

Section: Antibacterial Effects Of Pdt On Periodontal Pathogens In Vitromentioning

confidence: 99%

“…Park et al 18 found that 0.3 mM TBO and LED light with a wavelength of 650 nm effectively reduced the viability of the planktonic A. actinomycetemcomitans by 90%. In cases where A. actinomycetemcomitans forms a biofilm, Etemadi et al 22 used a diode laser with a 635 nm wavelength to activate 125 μg/mL phytocyanin decreased by 40.07%, while Su et al 23 found PDT could reach an eradication of 98%. Above all, the reduction of PDT against A. actinomycetemcomitans ranged from 40.07% to 98%.…”

Section: A Actinomycetemcomitansmentioning

confidence: 99%

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Photodynamic therapy in periodontitis: A narrative review

Nie,

Zhang,

Pathak

et al. 2024

Photoderm Photoimm Photomed

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BackgroundPeriodontitis, a chronic infectious disease, is primarily caused by a dysbiotic microbiome, leading to the destruction of tooth‐supporting tissues and tooth loss. Photodynamic therapy (PDT), which combines excitation light with photosensitizers (PS) and oxygen to produce antibacterial reactive oxygen species, is emerging as a promising adjuvant treatment for periodontitis.MethodsThis review focuses on studies examining the antibacterial effects of PDT against periodontal pathogens. It also explores the impact of PDT on various aspects of periodontal health, including periodontal immune cells, human gingival fibroblasts, gingival collagen, inflammatory mediators, cytokines in the periodontium, vascular oxidative stress, vascular behavior, and alveolar bone health. Clinical trials assessing the types of PSs and light sources used in PDT, as well as its effects on clinical and immune factors in gingival sulcus fluid and the bacterial composition of dental plaque, are discussed.ResultsThe findings indicate that PDT is effective in reducing periodontal pathogens and improving markers of periodontal health. It has shown positive impacts on periodontal immune response, tissue integrity, and alveolar bone preservation. Clinical trials have demonstrated improvements in periodontal health and alterations in the microbial composition of dental plaque when PDT is used alongside conventional treatments.ConclusionsPDT offers a promising adjunctive treatment for periodontitis, with benefits in bacterial reduction, tissue healing, and immune modulation. This article highlights the potential of PDT in periodontal therapy and emphasizes the need for further research to refine its clinical application and efficacy.

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Section: Antibacterial Effects Of Pdt On Periodontal Pathogens In Vitromentioning

confidence: 99%

Section: A Actinomycetemcomitansmentioning

confidence: 99%

Photodynamic therapy in periodontitis: A narrative review

Nie,

Zhang,

Pathak

et al. 2024

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

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Optimization of Photobiomodulation Dose in Biological Tissue by Adjusting the Focal Point of Lens

Chiu

et al. 2022

Photonics

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The optical power density in biotissue is an important issue for photobiomodulation (PBM) clinical applications. In our previous study, the maximal dose and the power density distributions of 830 nm lasers under human skin could be exactly calculated and measured. In this work, the laser power density in tissue can be changed by adjusting the focal point of the lens. From the experimental results, it is evident that the power densities on the attached gingiva and the surrounding tissues can be improved. Thus, the dose of a near-infrared (NIR) laser in the target tissue can be increased with a suitable lens. Most importantly, focusing lasers on deeper tissue can avoid any damage to the skin. This study provides a dose optimization method on the target tissue, and the results can be applied to clinical applications, especially laser acupuncture (LA).

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Optical profile: A key determinant of antibacterial efficacy of photodynamic therapy in dentistry

Cited by 2 publications

References 18 publications

Photodynamic therapy in periodontitis: A narrative review

Photodynamic therapy in periodontitis: A narrative review

Optimization of Photobiomodulation Dose in Biological Tissue by Adjusting the Focal Point of Lens

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