Optical probe based on double-clad optical fiber for fluorescence spectroscopy

Choi, Hae Young; Jung, Yongmin; Lee, Byeong Ha; Kim, K.

doi:10.1364/oe.15.017681

Cited by 38 publications

(23 citation statements)

References 17 publications

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“…The shape of the tip determines how the light emerging from the fiber is distributed on a tissue sample and also determines the light collection efficiency for viewing the irradiated tissue sample or examining scattered or fluorescing light emitted from the sample. [84][85][86][87][88][89][90][91][92][93][94][95][96] When deciding on the geometry of an optical fiber tip, parameters that need to be evaluated include the sizes of the illumination and light-collection areas, the collection angle (related to the fiber NA), and the fiber diameter. Another important factor to keep in mind is that biological tissue has a multilayered characteristic from both compositional and functional viewpoints.…”

Section: Optical Fiber Biomedical Probesmentioning

confidence: 99%

Review of diverse optical fibers used in biomedical research and clinical practice

et al. 2014

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Abstract. Optical fiber technology has significantly bolstered the growth of photonics applications in basic life sciences research and in biomedical diagnosis, therapy, monitoring, and surgery. The unique operational characteristics of diverse fibers have been exploited to realize advanced biomedical functions in areas such as illumination, imaging, minimally invasive surgery, tissue ablation, biological sensing, and tissue diagnosis. This review paper provides the necessary background to understand how optical fibers function, to describe the various categories of available fibers, and to illustrate how specific fibers are used for selected biomedical photonics applications. Research articles and vendor data sheets were consulted to describe the operational characteristics of conventional and specialty multimode and single-mode solid-core fibers, double-clad fibers, hard-clad silica fibers, conventional hollow-core fibers, photonic crystal fibers, polymer optical fibers, side-emitting and side-firing fibers, middle-infrared fibers, and optical fiber bundles. Representative applications from the recent literature illustrate how various fibers can be utilized in a wide range of biomedical disciplines. In addition to helping researchers refine current experimental setups, the material in this review paper will help conceptualize and develop emerging optical fiber-based diagnostic and analysis tools.

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Section: Optical Fiber Biomedical Probesmentioning

confidence: 99%

Review of diverse optical fibers used in biomedical research and clinical practice

et al. 2014

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“…A preform of a conventional SMF is drawn with a conventional fiber drawing tower but the fiber is coated with a low-index polymer instead of a conventional high-index one during the drawing process. Figure 3 shows the cross-sectional schematic and the refractive index profile of the previously reported polymer-clad DCF [24][25], for which UVF PC-409 AP of Luvantix, Korea, was used as the low-index polymer. The diameters of the core, the inner cladding, and the outer cladding were 10 μm, 125 μm, and 250 μm, respectively, in a step index profile.…”

Section: Double Clad Fiber Couplermentioning

confidence: 99%

“…He showed that with a short elongation length the HAF coupler had WDM properties but with a long elongation length it became a high-pass filter. In 2007, L. Wang et al utilized the double-clad optical fiber (DCF) coupler to couple only the cladding modes, not the core mode, of two single mode fibers (SMFs) for the fluorescence spectroscopy [12].…”

mentioning

confidence: 99%

Specialty Fiber Coupler: Fabrications and Applications

Lee¹,

Eom²,

Park³

et al. 2010

Journal of the Optical Society of Korea

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We review the research on specialty fiber couplers with emphasis placed on the characteristics that make them attractive for biomedical imaging, optical communications, and sensing applications. The fabrication of fiber couplers has been carried out with, in addition to conventional single mode fiber, various specialty fibers such as photonic crystal fiber, double clad fiber, and hole-assisted fiber with a Ge-doped core. For the fiber coupler fabrication, the side polishing and the fused biconical tapered methods have been developed. These specialty fiber couplers have been applied to optical coherence tomography, fluorescence spectroscopy, fiber sensors, and optical communication systems. This review aims to provide a detailed statement on the recent progress and novel applications of specialty fiber couplers.

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“…Double-clad fiber (DCF) can also provide a common path for the two modalities that ensures co-registration. Additionally, DCF has relatively high AF collection efficiency due to the large inner cladding [33][34][35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

Pahlevaninezhad¹,

Lee²,

Shaipanich³

et al. 2014

Biomed. Opt. Express

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Abstract:We present a power-efficient fiber-based imaging system capable of co-registered autofluorescence imaging and optical coherence tomography (AF/OCT). The system employs a custom fiber optic rotary joint (FORJ) with an embedded dichroic mirror to efficiently combine the OCT and AF pathways. This three-port wavelength multiplexing FORJ setup has a throughput of more than 83% for collected AF emission, significantly more efficient compared to previously reported fiber-based methods. A custom 900 µm diameter catheter -consisting of a rotating lens assembly, double-clad fiber (DCF), and torque cable in a stationary plastic tube -was fabricated to allow AF/OCT imaging of small airways in vivo. We demonstrate the performance of this system ex vivo in resected porcine airway specimens and in vivo in human on fingers, in the oral cavity, and in peripheral airways. 36. S. Liang, A. Saidi, J. Jing, G. Liu, J. Li, J. Zhang, C. Sun, J. Narula, and Z. Chen, "Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner," J.

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Optical probe based on double-clad optical fiber for fluorescence spectroscopy

Cited by 38 publications

References 17 publications

Review of diverse optical fibers used in biomedical research and clinical practice

Review of diverse optical fibers used in biomedical research and clinical practice

Specialty Fiber Coupler: Fabrications and Applications

A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

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