Optical molecular imaging‐guided radiation therapy part 1: Integrated x‐ray and bioluminescence tomography

Shi, Junwei; Udayakumar, Thirupandiyur S.; Wang, Zhi­qun; Dogan, Nesrin; Pollack, Alan; Yang, Yidong

doi:10.1002/mp.12415

Cited by 21 publications

(9 citation statements)

References 37 publications

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“…It is imperative for us to develop the QBLT to accurately quantify the spatial distribution of the underlying tumor for radiation guidance. Recently, there are several studies showing the potentiality of applying BLT for radiation guidance (13,(19)(20)(21)(22). The significance of this work is that we devised a comprehensive approach to systematically tackle the known challenging of optical tomography for in vivo target delineation, quantify its uncertainties in both biology and tissue optics for localization, and present the practicality for radiation guidance.…”

Section: Discussionmentioning

confidence: 99%

“…To bridge this gap and translate BLT-guided irradiation for practical use by investigators, we present a comprehensive study of achieving quantitative BLT (QBLT) that enables image-guided conformal irradiation based on 3D bioluminescence distribution in vivo. In this work, different from our and other groups' previous work (13,(19)(20)(21)(22), we made great effort not only optimizing hardware, algorithm, and calibration methods, but also quantifying biological variation and providing the approach of designing radiation margin for BLTguided RT.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research

Deng

Dehghani

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research

Deng

Dehghani

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

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“…Menichetti et al demonstrated the usefulness of [ 18 F]FET-PET guided boron neutron capture therapy in F98 rats [33]. However, several groups have been incorporating optical molecular imaging techniques such as bioluminescence and fluorescence imaging, to guide RT successfully [34–38]. Unfortunately, optical imaging has limited spatial resolution due to tissue absorption and scatter of visible light and background artifacts need to be taken into account caused by auto-fluorescence [39].…”

Section: Discussionmentioning

confidence: 99%

Technical feasibility of [18F]FET and [18F]FAZA PET guided radiotherapy in a F98 glioblastoma rat model

et al. 2019

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Background Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolomide (TMZ). An accurate definition of the tumor volume is of utmost importance for guiding RT. In this project we investigated the feasibility and treatment response of subvolume boosting to a PET-defined tumor part. Method F98 GB cells inoculated in the rat brain were imaged using T2- and contrast-enhanced T1-weighted (T1w) MRI. A dose of 20 Gy (5 × 5 mm 2 ) was delivered to the target volume delineated based on T1w MRI for three treatment groups. Two of those treatment groups received an additional radiation boost of 5 Gy (1 × 1 mm 2 ) delivered to the region either with maximum [ 18 F]FET or [ 18 F]FAZA PET tracer uptake, respectively. All therapy groups received intraperitoneal (IP) injections of TMZ. Finally, a control group received no RT and only control IP injections. The average, minimum and maximum dose, as well as the D 90 -, D 50 - and D 2 - values were calculated for nine rats using both RT plans. To evaluate response to therapy, follow-up tumor volumes were delineated based on T1w MRI. Results When comparing the dose volume histograms, a significant difference was found exclusively between the D 2 -values. A significant difference in tumor growth was only found between active therapy and sham therapy respectively, while no significant differences were found when comparing the three treatment groups. Conclusion In this study we showed the feasibility of PET guided subvolume boosting of F98 glioblastoma in rats. No evidence was found for a beneficial effect regarding tumor response. However, improvements for dose targeting in rodents and studies investigating new targeted drugs for GB treatment are mandatory. Electronic supplementary material The online version of this article (10.1186/s13014-019-1290-4) contains supplementary material, which is available to authorized users.

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“…The quality of reconstructed XFT images was assessed using CNR, DSC, and LE metrics (16,28). The CNR was…”

Section: Comparison Of Reconstruction Algorithmsmentioning

confidence: 99%

Quantitative X-ray fluorescence imaging of gold nanoparticles using joint L1 and total variation regularized reconstruction

Shi¹,

Granger²,

Xu³

et al. 2020

Quant Imaging Med Surg

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Background: This work proposed a joint L1 and total variation (TV) regularized reconstruction method for X-ray fluorescence tomography (XFT), and investigated the performance of this method in quantitative imaging of gold nanoparticles (GNPs). Methods:We developed a dual-modality XFT/CT imaging system which consisted of a benchtop X-ray source, a translation/rotation stage, a silicon drift detector for X-ray fluorescence (XRF) detection, and a flat panel detector for transmission X-ray detection. A pencil-beam collimator was 3D printed with steel and employed in sample excitation. The sensitivity of the XFT imaging system was determined by imaging water phantoms with multiple inserts containing GNP solutions of various concentrations (0.02-0.16 wt.%).A joint L1 and total variation (TV) regularized algorithm was developed for XFT reconstruction, where the L1 regularization was used to reduce image artifacts and the TV regularization was used to preserve the shape of targets. Nonlinear conjugate gradient (NCG) descent algorithm with backtracking line search was adopted to solve the reconstruction problem. We compared the L1 + TV regularization method with filtered back projection (FBP), maximum likelihood expectation maximization (ML-EM), L1 regularization, and TV regularization methods. Contrast-to-noise ratio (CNR), Dice similarity coefficient (DSC) and localization error (LE) metrics were used to compare the performance of different methods. The CT and XFT imaging doses were also measured using EBT2 radiochromic films.Results: The 3D printed pencil-beam collimator shaped an excitation beam with a 2 mm full width at half maximum at the imaging isocenter. Based on the phantom imaging experiments, the joint L1 and TV regularization method performed better than FBP, ML-EM, L1 regularization and TV regularization methods, with higher localization accuracy (offset <0.6 mm), CNR and DSC values. Compared with CT, XFT with L1 + TV regularized reconstruction demonstrated higher sensitivity in GNP imaging, and could detect GNP at a concentration of 0.02 wt.% or lower. Moreover, there existed a significant linear correlation (R 2 >0.99) between the reconstructed and true GNP concentration. The estimated XFT imaging dose is about 41.22 cGy under current setting. Conclusions:The joint L1 + TV regularized reconstruction algorithm performed better in noise suppression and shape preservation. Using the L1 + TV regularized reconstruction, the XFT system is able to localize GNP targets with submillimeter accuracy and quantify GNP distribution at a concentration of 0.02 wt.% or lower.

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Optical molecular imaging‐guided radiation therapy part 1: Integrated x‐ray and bioluminescence tomography

Abstract: Together with CT, BLT can provide precision radiation guidance and robust tumor volume assessment in small animal cancer research.

Cited by 21 publications

References 37 publications

Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research

Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research

Technical feasibility of [18F]FET and [18F]FAZA PET guided radiotherapy in a F98 glioblastoma rat model

Quantitative X-ray fluorescence imaging of gold nanoparticles using joint L1 and total variation regularized reconstruction

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