“…This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. 24 (71.05% yield) 1 H NMR (400 MHz, CDCl 3 , Me 4 Si) d 4.46 (dd, J ¼ 11.4, 3.6 Hz, 1H), 3.54 (s, 2H), 3.27-3.18 (m, 2H), 3.10-3.00 (m, 2H), 1.79 (s, 2H), 1.76-1.29 (m, 8H).4.1.1.2 General procedure for the synthesis of compound tertbutyl 4-(8-nitro-4-oxo-6-(triuoromethyl)-4H-benzo[e][1,3]thiazin-2-yl)piperazine-1-carboxylate. To 3 g of 2-chloro-3-nitro-5-(triuoromethyl)benzoic acid in dichloromethane 2.64 mL of oxalyl chloride and 0.05 mL DMF were added.…”