Optical Coherence Tomography Study of Retinal Changes in Normal Aging and After Ischemia

Shariati, Mohammad Ali; Park, Joyce Ho; Liao, Yaping Joyce

doi:10.1167/iovs.14-15145

Cited by 31 publications

(32 citation statements)

References 69 publications

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“…Using these approaches, we did not see any difference in vision between APP/PS1 and WT mice, although clear aging effects were seen. The age-related changes in retinal function and structure seen here are consistent with those previously documented for both mice (Kolesnikov, Fan, Crouch, & Kefalov, 2010;Shariati, Park, & Liao, 2015;Vessey et al, 2015) and rats (Nadal-Nicolás, Vidal-Sanz, & Agudo-Barriuso, 2018). The current study highlights that at a very advanced age there is thinning of the retinal nerve fibre layer, without a change in total retina thickness ( Figure 4C).…”

Section: Discussionsupporting

confidence: 90%

Progressive impairments in executive function in the APP/PS1 model of Alzheimer’s disease as measured by translatable touchscreen testing

Shepherd

Lim

Wong

et al. 2019

Preprint

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Executive function deficits in Alzheimer's disease (AD) occur early in disease progression and may be predictive of cognitive decline. However, no preclinical studies have identified deficits in rewarded executive function in the commonly used APP/PS1 mouse model. To address this, we assessed 12-26 month old APP/PS1 mice on rewarded reversal and/or extinction tasks. 16-month-old, but not 13-or 26-monthold, APP/PS1 mice showed an attenuated rate of extinction. Reversal deficits were seen in 22-month-old, but not 13-month-old APP/PS1 animals. We then confirmed that impairments in reversal were unrelated to previously reported visual impairments in both AD mouse models and humans. Age, but not genotype, had a significant effect on markers of retinal health, indicating the deficits seen in APP/PS1 mice were directly related to cognition. This is the first characterisation of rewarded executive function in APP/PS1 mice, and has great potential to facilitate translation from preclinical models to the clinic.

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Section: Discussionsupporting

confidence: 90%

Progressive impairments in executive function in the APP/PS1 model of Alzheimer’s disease as measured by translatable touchscreen testing

Shepherd

Lim

Wong

et al. 2019

Preprint

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“…Nevertheless, the relationship between SmVD as well as DmVD and structural damage in progressed NTG patients has rarely been reported elsewhere, and the association between basal FAZ area and VF defects in these patients further supports the previous concept that a larger FAZ was found in NTG [30]. These results further support that vascular abnormalities may be the main cause of glaucoma neuropathy in NTG, especially in progressed cases, which has been proven in both animal and human research [34, 35]. Briefly, the preceding vascular impairment in progressed NTG is correlated with subsequent glaucoma neuropathy more prevalently than in progressed HTG.…”

Section: Discussionsupporting

confidence: 81%

Correlation between Basal Macular Circulation and Following Glaucomatous Damage in Progressed High-Tension and Normal-Tension Glaucoma

et al. 2019

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Objectives: Evaluate the correlation between basal macular circulation and late structural damage in progressed high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) via optical coherence tomography angiography (OCTA). Methods: Patients who received an OCTA examination were divided into progressed HTG, progressed NTG, and well-controlled HTG (control) groups. Superficial macular vessel density (SmVD), deep macular vessel density (DmVD), foveal avascular zone (FAZ), and flow area of the outer retina and choriocapillaris were obtained by one OCTA device. Associations between macular angiography and glaucoma parameters, including the visual field, retinal nerve fiber layer, and ganglion cell complex, were analyzed. Results: A total of 60 eyes from 60 patients were enrolled. The progressed HTG and NTG groups had lower SmVD than the control group, while the progressed NTG group had lower DmVD and a larger FAZ than the control group. The flow area of the outer retina in the progressed HTG group was lower than that of the control. A significant correlation between SmVD and glaucoma parameters was found in the progressed HTG group, while a similar correlation between SmVD and DmVD to glaucoma parameters was observed in the progressed NTG group. Conclusion: The progressed HTG and NTG patients showed an impaired vascular intake before significant disease development compared to well-controlled cases.

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“…[20][21][22] The high resolution of third-generation spectral-domain OCT devices renders in vivo retinal imaging in mice and rats possible, gaining an increasing importance in ophthalmological and neurological preclinical research. [23][24][25][26][27][28][29][30][31][32][33] The obtained results are in good accordance with histological sections of the animals' retinae. 34 The application of OCT technology in rodent models, however, is still challenging, mainly because of the small size of the rodents' eyes.…”

Section: Introductionsupporting

confidence: 82%

Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide

et al. 2016

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BackgroundIn vivo retinal imaging of rodents has gained a growing interest in ophthalmology and neurology. The bedding of the animals with the possibility to perform adjustments in order to obtain an ideal camera-to-eye angle is challenging.MethodsWe provide a guide for a cost-effective, do-it-yourself rodent holder for ocular imaging techniques. The set-up was tested and refined in over 2000 optical coherence tomography measurements of mice and rats.ResultsThe recommended material is very affordable, readily available and easily assembled. The holder can be adapted to both mice and rats. A custom-made mouthpiece is provided for the use of inhalant anaesthesia. The holder is highly functional and assures that the rodent’s eye is the centre of rotation for adjustments in both the axial and the transverse planes with a major time benefit over unrestrained positioning of the rodents.ConclusionWe believe this guide is very useful for eye researchers focusing on in vivo retinal imaging in rodents as it significantly reduces examination times for ocular imaging.

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Optical Coherence Tomography Study of Retinal Changes in Normal Aging and After Ischemia

Cited by 31 publications

References 69 publications

Progressive impairments in executive function in the APP/PS1 model of Alzheimer’s disease as measured by translatable touchscreen testing

Progressive impairments in executive function in the APP/PS1 model of Alzheimer’s disease as measured by translatable touchscreen testing

Correlation between Basal Macular Circulation and Following Glaucomatous Damage in Progressed High-Tension and Normal-Tension Glaucoma

Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide

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