Optical coherence tomography platforms and parameters for glaucoma diagnosis and progression

Mwanza, Jean-Claude; Budenz, Donald L.

doi:10.1097/icu.0000000000000231

Cited by 34 publications

(24 citation statements)

References 43 publications

(23 reference statements)

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“…The persistence of axonal swelling, which most probably relates to a stasis of organellar transport, resolves at a slower rate. Lacking a longitudinal follow‐up at the crucial transition from pre‐clinical to conversion, we can only speculate on what triggers conversion and we cannot exclude that the VD reduction is only a consequence of optic nerve atrophy, similarly to other chronic optic neuropathy . However, one hypothesis to explain the catastrophic rapidity of disease onset, which occurs in days to weeks may implicate some anatomical considerations.…”

Section: Discussionmentioning

confidence: 95%

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Peripapillary vessel density changes in Leber's hereditary optic neuropathy: a new biomarker

Balducci¹,

Cascavilla

Ciardella

et al. 2018

Clinical Exper Ophthalmology

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Significant peripapillary miscrovascular changes were detected over the different stages of LHON. Studying the vascular network separately from fibres revealed that microvascular changes in the temporal sector preceded the changes of RNFL and mirrored the GC-IPL changes. Measurements of the peripapillary vascular network may become a useful biomarker to monitor the disease process, evaluate therapeutic efficacy and elucidate pathophysiology.

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Section: Discussionmentioning

confidence: 95%

“…Using the split‐spectrum amplitude‐decorrelation angiography (SSADA) algorithm, vascular perfusion can be quantified . OCT‐A has been used to detect microvasculature reduction in other optic neuropathies . To date, only single case reports have qualitatively described microvascular changes in LHON detected by OCT‐A …”

Section: Introductionmentioning

confidence: 99%

Peripapillary vessel density changes in Leber's hereditary optic neuropathy: a new biomarker

Balducci¹,

Cascavilla

Ciardella

et al. 2018

Clinical Exper Ophthalmology

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“…It is worth noting that observed pre-perimetric structural losses could be an artifact of the testing method. SAP only has the ability to detect functional deficits after at least 25–50% of RGCs have undergone apoptosis (Harwerth et al, 1999; Kerrigan-Baumrind et al, 2000; Medeiros et al, 2013; Miglior et al, 2005; Mwanza and Budenz, 2015; Quigley et al, 1989; Strouthidis et al, 2006; Wollstein et al, 2005). Harwerth et al, for example, demonstrated in a population of 10 rhesus monkeys that SAP testing could not provide a useful estimate of ganglion cell losses at early stages of VF defects.…”

Section: The Expanding Role Of Ao-octmentioning

confidence: 99%

Adaptive optics optical coherence tomography in glaucoma

Dong

Wollstein

Wang

et al. 2017

Progress in Retinal and Eye Research

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Since the introduction of commercial optical coherence tomography (OCT) systems, the ophthalmic imaging modality has rapidly expanded and it has since changed the paradigm of visualization of the retina and revolutionized the management and diagnosis of neuro-retinal diseases, including glaucoma. OCT remains a dynamic and evolving imaging modality, growing from time-domain OCT to the improved spectral-domain OCT, adapting novel image analysis and processing methods, and onto the newer swept-source OCT and the implementation of adaptive optics (AO) into OCT. The incorporation of AO into ophthalmic imaging modalities has enhanced OCT by improving image resolution and quality, particularly in the posterior segment of the eye. Although OCT previously captured in-vivo cross-sectional images with unparalleled high resolution in the axial direction, monochromatic aberrations of the eye limit transverse or lateral resolution to about 15-20 μm and reduce overall image quality. In pairing AO technology with OCT, it is now possible to obtain diffraction-limited resolution images of the optic nerve head and retina in three-dimensions, increasing resolution down to a theoretical 3 μm3. It is now possible to visualize discrete structures within the posterior eye, such as photoreceptors, retinal nerve fiber layer bundles, the lamina cribrosa, and other structures relevant to glaucoma. Despite its limitations and barriers to widespread commercialization, the expanding role of AO in OCT is propelling this technology into clinical trials and onto becoming an invaluable modality in the clinician's arsenal.

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“…Doppler OCT, although able to detect to motion parallel to the OCT beam, has a limited ability to visualize motion predominantly perpendicular to the probe, such as is the case in retinal and choroidal circulations. Although hemodynamic parameters may be useful in diagnosis 78 and management of glaucoma, its true clinical utility remains to be determined.…”

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confidence: 99%

Clinical Utility of Optical Coherence Tomography in Glaucoma

Dong

Wollstein

Schuman

2016

Invest. Ophthalmol. Vis. Sci.

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Optical coherence tomography (OCT) has established itself as the dominant imaging modality in the management of glaucoma and retinal diseases, providing high-resolution visualization of ocular microstructures and objective quantification of tissue thickness and change. This article reviews the history of OCT imaging with a specific focus on glaucoma. We examine the clinical utility of OCT with respect to diagnosis and progression monitoring, with additional emphasis on advances in OCT technology that continue to facilitate glaucoma research and inform clinical management strategies.

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Optical coherence tomography platforms and parameters for glaucoma diagnosis and progression

Abstract: OCT technology is advancing not only as a tool for structural assessment, but also as a multimodality tool to assess both structure and function to enhance our understanding of glaucoma, and ultimately clinical decisions.

Cited by 34 publications

References 43 publications

Peripapillary vessel density changes in Leber's hereditary optic neuropathy: a new biomarker

Peripapillary vessel density changes in Leber's hereditary optic neuropathy: a new biomarker

Adaptive optics optical coherence tomography in glaucoma

Clinical Utility of Optical Coherence Tomography in Glaucoma

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