Optical coherence tomography manifestations of primary vitreoretinal lymphoma

Abstract

Although pretreatment cases and recurrent cases showed similar OCT abnormalities and the specific changes in the various disease stages were unclarified, collecting OCT data from various disease stages will facilitate detection of typical OCT changes of PVRL and lead to early diagnosis and treatment.

Longitudinal observation of OCT imaging is a valuable tool to monitor primary vitreoretinal lymphoma treated with intravitreal injections of methotrexate

“…In this report, we present the characteristic OCT features of PVRL at the initial visit, derived from a series of SD-OCT images of consecutive eyes with biopsy-proven PVRL. These features were in accordance with previously published reports [2,11,12]. We further present that these observed features decreased gradually and finally vanished after therapy.…”

Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis

“…While early diagnosis of localised ocular disease is unlikely to influence eventual mortality rates, it has been shown to prolong survival 13. Non-invasive imaging modalities such as spectral domain optical coherence tomography (SD-OCT) have previously been demonstrated as potential aids to diagnosis, although existing data are largely limited to case reports or very small case series14–17 or from patients following treatment where the diagnosis of PVRL has already been made 18…”

Macular edema is a rare finding in untreated vitreoretinal lymphoma: small case series and review of the literature

“…The rate varies widely from 2.46% to 66.6% of cases. Patients with VRL who present ME also can have other possible sources of ME, such as antecedents of whole-brain radiotherapy (WBRT), chemotherapy (CT), epiretinal membranes, and/or intraocular procedures [12–15, 23, 24]. …”

“…eyes with macular oedema (%)Total no. of eyes with prior treatmentCassoux et al [12]44812 (2.46%)3 had PPVVelez et al [13]17316 (19%)4 had cataract surgery1 had PPVFardeau et al [14]53?6 patients (11.3%)?Turaka et al [15]810 with FFA3 with OCT6 (60%)2 (66.6%)50% CT25% RT25% CT + RTJang et al [23]552 (40%)1 eye was a secondary VRL, so we assume that had previous CT and/or RTSaito et al [24]20263 (11.53%)2 eyes had ERMOur series9156 (40%)5 eyes had CT + RT4 eyes had intraocular surgery VRL vitreoretinal lymphoma, No number, PPV pars plana vitrectomy, CT chemotherapy, RT radiotherapy, ERM epiretinal membrane …”

“…Saito et al [24] describes 11.53% of ME in PVRL (3 of 26 eyes), but history of previous intraocular procedures is not specified. However, 2 of 3 eyes (1 patient) presented epiretinal membranes in the initial presentation; therefore, that could be considered a risk factor to develop macular oedema.…”