Optical Coherence Tomography in High Myopia

Schuman, Joel S.

doi:10.1001/jamaophthalmol.2016.2017

Cited by 10 publications

(4 citation statements)

References 2 publications

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“…Moreover, it is worth emphasizing that Cirrus HD OCT does not have correction for the magnification effect in myopic eyes and this correction is usually not clinically used, so there is a chance that our results may be slightly different if this correction were made. 25,26 However, the error associated with image magnification in myopia up to −10 D is negligible 27 and in our study the group of only two patients had myopia higher than −10 D, which could not significantly influence the obtained results.…”

Section: Discussioncontrasting

confidence: 54%

Correlation between retrobulbar blood flow parameters and retinal nerve fiber, ganglion cell and inner plexus layer thickness in myopia

Grudzińska

Zaborski

Modrzejewska

2021

European Journal of Ophthalmology

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Purpose: To assess the thickness of the retinal nerve fiber layer (RNFL), ganglion cell and inner plexus layer (GCIPL) and blood flow parameters in retrobulbar vessels, and to analyze correlations between these parameters in myopes. Methods: The study included forty myopic and 20 healthy eyes. Standard eye examination was supplemented with OCT of the optic nerve and macula (GCIPL, RNFL, RNFL in each quadrant and rim area of the optic nerve) and color Doppler imaging of retrobulbar arteries [peak systolic and end-diastolic velocities, pulsatile index and resistance index (RI) in the ophthalmic (OA), central retinal (CRA), nasal posterior ciliary and temporal posterior ciliary arteries]. Results: Significant correlations were found between blood flow parameters in the CRA, RNFL and GCIPL thickness, and axial length (AL) and spherical equivalent (SE). There were significant positive correlations between RNFL with PSV and EDV in the CRA and negative correlations between RNFL and RI in the CRA. GCIPL was positively correlated with PSV and EDV in the CRA. The decrease in RA was associated with reduced blood flow velocities in the CRA, TPCA and NPCA. Conclusion: The reduced retrobulbar blood flow in healthy young myopes is correlated with increasing AL and refractive value, and thinning of the RNFL and GCIPL. Reduction of the rim-area of the optic disc is associated with vascular and retinal circulatory disorders. These phenomena indicate the vascular basis of the described changes. To the best of our knowledge, this is the first study which correlates ocular circulation with retinal structure.

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Section: Discussioncontrasting

confidence: 54%

Correlation between retrobulbar blood flow parameters and retinal nerve fiber, ganglion cell and inner plexus layer thickness in myopia

Grudzińska

Zaborski

Modrzejewska

2021

European Journal of Ophthalmology

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“…It is often caused by high myopia, mainly due to pseudo-thinning of the RNFL which is stretched to cover the elongated globe. 16 , 17 Schuman 16 and Chong and Lee. 17 have suggested using macular OCT data for glaucoma screening in patients with high axial myopia and stated that the causes of this OCT abnormality are negligible up to -10 D. In our study, there was no subject over -10 D. However, red disease should always be kept in mind while evaluating myopic patients for glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Alterations in the Retinal Nerve Fiber Layer Thickness Color Map in Non- Glaucomatous Eyes with Myopia

Yılmaz¹,

Köylü²,

Yeşiltaş³

et al. 2021

tjo

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Objectives: To determine the normal values for retinal nerve fiber layer thickness (RNFLT) in myopic patients without glaucoma and analyze the changes in their color map. Materials and Methods: A total of 245 eyes without glaucoma were included in the study. According to the degree of myopia, the cases were divided into 4 groups: control group (+1.00/-1.00 D; n=70), Group 1 (-1.00/-3.00 D; n=50), Group 2 (-3.00/-6.00 D; n=75), and Group 3 (>-6.00 D; n=50). Intra-group comparisons were performed in terms of superotemporal, superonasal, nasal, inferonasal, inferotemporal, temporal, and global RNFLT (Heidelberg Spectralis, Optic Coherence Tomography, Germany) and the color coding of these quadrants (green: within normal limits, yellow: borderline, red: outside normal limits). Results: All groups were similar in age and gender (p>0.05). As the degree of myopia increased, RNFLT became thinner in the upper and lower temporal and upper and lower nasal quadrants (p<0.01). The rate of measurements considered borderline and outside normal limit in at least 1 quadrant was higher in groups with higher myopia for all quadrants (p<0.05). This rate was found to be 8/70 (11.4%) for the control group, 9/50 (18.0%) for Group 1, 21/75 (28.0%) for Group 2, and 33/50 (66.0%) for Group 3 (p<0.01). Conclusion: The high rate of RNFLT classified as borderline or outside normal limits in myopic patients is a finding to which clinicians should pay attention in order not to make a misdiagnosis, especially in cases of suspected glaucoma.

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“…In our study design optical coherence tomography (OCT) was not included. OCT is an imaging technology that can be used for visualizing and analysing retinal tissue quickly and noninvasively [ 31 ]. It enables the detection of structural loss in the retinal nerve fiber layer (RNFL) before perimetric visible visual field defects and has become standard of care for detection of glaucoma and monitoring its progression and for detecting macular and retinal diseases [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of depression and anxiety among participants with glaucoma in a population-based cohort study: The Gutenberg Health Study

et al. 2018

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BackgroundTo investigate the prevalence of depression and anxiety among subjects with self-reported glaucoma and the association between self-reported glaucoma and depression respectively anxiety in a European cohort.MethodsA study sample of 14,657 participants aged 35 to 74 years was investigated in a population-based cohort study. All participants reported presence or absence of glaucoma. Ophthalmological examinations were carried out in all participants and demographic and disease related information were obtained by interview. Depression was assessed with the Patient Health Questionnaire (PHQ-9), and generalized anxiety with the two screening items (GAD-2) of the short form of the GAD-7 (Generalized Anxiety Disorder-7 Scale). Prevalence of depression and generalized anxiety were investigated for subjects with and without self-reported glaucoma. Logistic regression analyses with depression, respectively anxiety as dependent variable and self-reported glaucoma as independent variable were conducted and adjusted for socio-demographic factors, systemic comorbidities (arterial hypertension, myocardial infarction, stroke, diabetes mellitus, chronic obstructive pulmonary disease, cancer), ocular diseases (cataract, macular degeneration, corneal diseases, diabetic retinopathy), visual acuity, intraocular pressure, antiglaucoma eye drops (sympathomimetics, parasympathomimetics, carbonic anhydrase inhibitors, beta-blockers, prostaglandins) and general health status.Results293 participants (49.5% female) reported having glaucoma. Prevalence of depression among participants with and without self-reported glaucoma was 6.6% (95%-CI 4.1–10.3) respectively 7.7% (95%-CI 7.3–8.2), and for anxiety 5.3% (95%-CI 3.1–8.7) respectively 6.6% (95%-CI 6.2–7.1). Glaucoma was not associated with depression (Odds ratio 1.10, 95%-CI 0.50–2.38, p = 0.80) or anxiety (1.48, 95%-CI 0.63–3.30, p = 0.35) after adjustment for socio-demographic factors, ocular/systemic diseases, ocular parameters, antiglaucoma drugs and general health status. A restriction to self-reported glaucoma cases either taking topical antiglaucoma medications or having a history of glaucoma surgery did not alter the result.ConclusionsThis is the first study analyzing both depression and anxiety among glaucoma patients in a European cohort. Subjects with and without self-reported glaucoma had a similar prevalence of depression and anxiety in our population-based sample. Self-reported glaucoma was not associated with depression or anxiety. A lack of a burden of depressive symptoms may result from recruitment from a population-based sample as compared to previous study groups predominantly recruited from tertiary care hospitals.

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Optical Coherence Tomography in High Myopia

Cited by 10 publications

References 2 publications

Correlation between retrobulbar blood flow parameters and retinal nerve fiber, ganglion cell and inner plexus layer thickness in myopia

Correlation between retrobulbar blood flow parameters and retinal nerve fiber, ganglion cell and inner plexus layer thickness in myopia

Alterations in the Retinal Nerve Fiber Layer Thickness Color Map in Non- Glaucomatous Eyes with Myopia

Prevalence of depression and anxiety among participants with glaucoma in a population-based cohort study: The Gutenberg Health Study

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