Optical coherence tomography in coronary atherosclerosis assessment and intervention

Araki, Makoto; Park, Seung‐Jung; Dauerman, Harold L.; Uemura, Shiro; Kim, Jung-Sun; Mario, Carlo Di; Johnson, Tom; Guagliumi, Giulio; Kastrati, Adnan; Joner, Michael; Holm, Niels Ramsing; Alfonso, Fernándo; Wijns, William; Adriaenssens, Tom; Nef, Holger; Rioufol, Gilles; Amabile, Nicolas; Souteyrand, Géraud; Meneveau, Nicolas; Gerbaud, Édouard; Opolski, Maksymilian P.; Gonzalo, Nieves; Tearney, Guillermo J.; Bouma, Brett E.; Aguirre, Aaron D.; Mintz, Gary S.; Stone, Gregg W.; Bourantas, Christos V.; Räber, Lorenz; Gili, Sebastiano; Mizuno, Kyoichi; Kimura, Shigeki; Shinke, Toshiro; Hong, Myeong‐Ki; Jang, Yangsoo; Cho, Jin Man; Yan, Bryan P.; Porto, Italo; Niccoli, Giampaolo; Montone, Rocco Antonio; Thondapu, Vikas; Papafaklis, Michail I.; Michalis, Lampros K.; Reynolds, Harmony R.; Saw, Jacqueline; Libby, Peter; Weisz, Giora; Iannaccone, Mario; Gori, Tommaso; Toutouzas, Konstantinos; Yonetsu, Taishi; Minami, Yoshiyasu; Takano, Masamichi; Raffel, O.; Kurihara, Osamu; Soeda, Tsunenari; Sugiyama, Tomoyo; Kim, Hyung Oh; Lee, Tetsumin; Higuma, Takumi; Nakajima, Ayako; Yamamoto, Etsuhide; Bryniarski, Krzysztof; Vito, Luca Di; Vergallo, Rocco; Fracassi, Francesco; Russo, Michele; Seegers, Lena Marie; McNulty, Iris; Park, Sangjoon; Feldman, Marc D.; Escaned, Javier; Prati, Francesco; Arbustini, Eloisa; Pinto, Fausto J.; Waksman, Ron; Garcia-Garcia, Hector; Maehara, Akiko; Ali, Ziad A.; Finn, Aloke V.; Virmani, Renu; Kini, Annapoorna; Daemen, Joost; Kume, Teruyoshi; Hibi, Kiyoshi; Tanaka, Atsushi; Akasaka, Takashi; Kubo, Takashi; Yasuda, Satoshi; Croce, Kevin; Granada, Juan F.; Lerman, Amir; Prasad, Abhiram; Regar, Evelyn; Saito, Yoshihiko; Ajit, Mullasari S.; Subban, Vijayakumar; Weissman, Neil J.; Chen, Yundai; Yu, Bo; Nicholls, Stephen J.; Barlis, Peter; West, Nick E.J.; Arbab‐Zadeh, Armin; Ye, Jong Chul; Dijkstra, Jouke; Lee, Hang; Narula, Jagat; Crea, Filippo; Nakamura, Sunao; Kakuta, Tsunekazu; Fujimoto, James G.; Fuster, Valentín; Jang, Ik‐Kyung

doi:10.1038/s41569-022-00687-9

Cited by 129 publications

(49 citation statements)

References 173 publications

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“…Plaque rupture is determined by a thin fibrous cap discontinuity, which exposes the highly thrombogenic plaque core to the coronary lumen and activates a pro-thrombotic and pro-inflammatory cascade responsible for thrombus formation [2,11], while plaque erosion is primarily due to the apoptosis of endothelial cells leading to thrombus formation without evidence of fibrous cap discontinuity [11–13]. Even in the absence of significant coronary obstruction, both plaque rupture and plaque erosion may cause MI through different mechanisms, including transient occlusive thrombosis with spontaneous thrombolysis, distal embolization, superimposed vasospasm or a combination of these processes [2].…”

Section: Pathophysiology Of Myocardial Infarction With Nonobstructive...mentioning

confidence: 99%

Myocardial infarction with nonobstructive coronary arteries: the need for precision medicine

Buono

Vecchia

Rinaldi

et al. 2022

Current Opinion in Cardiology

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Purpose of reviewMyocardial infarction with nonobstructive coronary arteries (MINOCA) represents about 6–8% of all patients with myocardial infarction (MI), and several pathophysiological mechanisms showed to be involved in this heterogeneous clinical condition. Of note, MINOCA proved to be associated with a significant risk of mortality, angina burden and socioeconomic costs.Recent findingsResults from randomized clinical trials evaluating the clinical effectiveness of a comprehensive diagnostic algorithm, along with the acute and long-term management of patients with MINOCA, are pending.SummaryIn this review article, we aim at providing an overview of the clinical features, diagnostic work-up and the therapeutic management of patients presenting with MINOCA, highlighting the recent acquisition along with the remaining important knowledge gaps in this field.

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Section: Pathophysiology Of Myocardial Infarction With Nonobstructive...mentioning

confidence: 99%

Myocardial infarction with nonobstructive coronary arteries: the need for precision medicine

Buono

Vecchia

Rinaldi

et al. 2022

Current Opinion in Cardiology

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“…Generally, plaque disruption cannot be accurately determined or distinguished by coronary angiography, it can only be definitively diagnosed with optical coherence tomography (OCT) or, to a lesser extent, with intravascular ultrasound (IVUS) (16)(17)(18). Nowadays, OCT has been an essential diagnostic modality for MINOCA (19). OCT can identify the hallmark of a culprit lesion, including plaque disruption and thrombus.…”

Section: Pathophysiology Of Minoca and Inocamentioning

confidence: 99%

Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction

Zhai

Fan

Zhu

et al. 2022

Front. Cardiovasc. Med.

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Non-obstructive coronary artery disease (CAD), which is defined as coronary stenosis <50%, has been increasingly recognized as an emerging entity in clinical practice. Vasomotion abnormality and coronary microvascular dysfunction are two major mechanisms contributing to the occur of angina with non-obstructive CAD. Although routine coronary functional assessment is limited due to several disadvantages, functional evaluation can help to understand the pathophysiological mechanism and/or to exclude specific etiologies. In this review, we summarized the potential mechanisms involved in ischemia with non-obstructive coronary arteries (INOCA) and myocardial infarction with non-obstructive coronary arteries (MINOCA), the two major form of non-obstructive CAD. Additionally, we reviewed currently available functional assessment indices and their use in non-obstructive CAD. Furthermore, we speculated that novel technique combined anatomic and physiologic parameters might provide more individualized therapeutic choice for patients with non-obstructive CAD.

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“…The primary limitation of commercially available intracoronary OCT is its penetration depth of 0.1 to 2 mm in plaques, compared to up to 10 mm for IVUS, which prevents visualization of the deep content of plaques, the external elastic membrane and adventitial layer in diseased regions [ 28 , 35 ]. This penetration depth decreases significantly in the presence of lipid rich plaques due to the high attenuation and low backscattering properties of lipid.…”

Section: Introductionmentioning

confidence: 99%

Automated Coronary Optical Coherence Tomography Feature Extraction with Application to Three-Dimensional Reconstruction

et al. 2022

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Coronary optical coherence tomography (OCT) is an intravascular, near-infrared light-based imaging modality capable of reaching axial resolutions of 10–20 µm. This resolution allows for accurate determination of high-risk plaque features, such as thin cap fibroatheroma; however, visualization of morphological features alone still provides unreliable positive predictive capability for plaque progression or future major adverse cardiovascular events (MACE). Biomechanical simulation could assist in this prediction, but this requires extracting morphological features from intravascular imaging to construct accurate three-dimensional (3D) simulations of patients’ arteries. Extracting these features is a laborious process, often carried out manually by trained experts. To address this challenge, numerous techniques have emerged to automate these processes while simultaneously overcoming difficulties associated with OCT imaging, such as its limited penetration depth. This systematic review summarizes advances in automated segmentation techniques from the past five years (2016–2021) with a focus on their application to the 3D reconstruction of vessels and their subsequent simulation. We discuss four categories based on the feature being processed, namely: coronary lumen; artery layers; plaque characteristics and subtypes; and stents. Areas for future innovation are also discussed as well as their potential for future translation.

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Optical coherence tomography in coronary atherosclerosis assessment and intervention

Cited by 129 publications

References 173 publications

Myocardial infarction with nonobstructive coronary arteries: the need for precision medicine

Myocardial infarction with nonobstructive coronary arteries: the need for precision medicine

Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction

Automated Coronary Optical Coherence Tomography Feature Extraction with Application to Three-Dimensional Reconstruction

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