Optical coherence tomography for glucose monitoring in blood

Ullah, Hafeez; Hussain, Fayyaz; Ikram, Manzoor

doi:10.1007/s00340-015-6144-7

Cited by 18 publications

(12 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blood, tumour and skin decorrelation times were measured using ACF (Figure 7 (d)) to be <1 ms, 480 ms and 830 ms, respectively. These numbers reflect the fast blood flow velocity within the vessel of such a diameter [41] and higher metabolic activity of tumour cells compared to skin cells in vivo [17]. In summary, one-dimensional M-mode analysis shows the potential of the reported synchronization metric to provide a novel contrast derivable from conventional OCT structural images.…”

Section: Resultsmentioning

confidence: 99%

Alternative Contrast Mechanism in Optical Coherence Tomography: Temporal Speckle Synchronization Effects

Demidov¹,

Demidova²,

Shabunin³

et al. 2018

Sovrem Tehnol Med

View full text Add to dashboard Cite

We propose an alternative optical coherence tomography (OCT) contrast mechanism based on analysis of speckle temporal synchronization using B-mode OCT structural images. We show that the changes in synchronized speckle intensities with time may be used to distinguish between different tissue types, thus providing a novel and potentially useful contrast for OCT imaging. The developed methodology is tested in scattering flow phantoms, and in vivo on cervical cancer tumour grown within a mouse dorsal skin window chamber model. Derived speckle synchronization metric is compared with autocorrelation function analysis to demonstrate its different nature. The phantom and pre-clinical in vivo results suggest that the proposed synchronization approach is sensitive to tissue type/pathology, potentially enabling tumour quantitative evaluation and its delineation from surrounding normal tissues.

show abstract

Section: Resultsmentioning

confidence: 99%

Alternative Contrast Mechanism in Optical Coherence Tomography: Temporal Speckle Synchronization Effects

Demidov¹,

Demidova²,

Shabunin³

et al. 2018

Sovrem Tehnol Med

View full text Add to dashboard Cite

show abstract

“…11 There are several non-invasive methods used to detect and monitor the glucose level in blood including Absorbance spectroscopy such as Near and Mid Infrared spectroscopy, Raman spectroscopy, Photoacoustic spectroscopy, Fluorescence spectrophotometry, Bioimpedance spectroscopy, Optical coherence tomography, and Thermal emission spectroscopy. [11][12][13][14][15][16][17][18][19]…”

Section: Bloodmentioning

confidence: 99%

“…Through the literature search for current review, we learned that techniques for non-or minimally invasive monitoring glucose via the skin have become most popular approach in recent years, where these approaches have been developed to counteract the challenges associated with patient compliance and invasive monitoring. 17,26 The leading approaches have been presented in Table 2 mainly classified as Optical and Electrochemical detection technology include Absorbance spectroscopy, Raman spectroscopy, Photoacoustic spectroscopy, Optical coherence tomography (OCT), Fluorescence spectrophotometry, Ocular spectroscopy, Metabolic heat conformation, Bio-impedance spectroscopy, Reverse iontophoresis, Enzymatic or Non-Enzymatic electrodes, and Colorimetric method. Table 2 also summarized about principle, target areas/body fluids of the latest emerging techniques in non-or minimally invasive glucose monitoring.…”

Section: Emerging Non-or Minimally Invasive Glucose Monitoring Technimentioning

confidence: 99%

Review of Emerging Approaches in Non- or Minimally Invasive Glucose Monitoring and their Application to Physiological Human Body Fluids

Jang¹

2018

IJBSBE

View full text Add to dashboard Cite

The frequent blood glucose monitoring by the diabetics and physicians is a very essential step in the management of the diabetes because this devastating disease can lead the patients to blindness, kidney disease, nervous & circulatory system disease, limb amputations, stroke and cardiovascular disease (CVD). There have been numerous attempts to develop viable painless non-or minimally invasive blood glucose monitoring techniques over the last five decades in order to replace all existing methods of home blood glucose monitoring require drawing a blood sample by piercing the skin. This review describes the principles of two main emerging general technologies such as optical and electrochemical glucose monitoring methods, which represent 12 specific techniques applying multivariate regression analyses converting feeble optical or electrochemical signal to glucose concentration. This review article also deals with advances utilizing integration of glucose sensing techniques into targeting areas by sampling potential alternative physiological human body fluids to blood such as interstitial fluid, urine, sweat, ocular fluids and saliva contain traces of blood glucose.

show abstract

“…18,19 Given the tremendous importance and significant challenges inherent in the unmet clinical need, noninvasive glucometry is an active area of OCT research. [20][21][22][23] Currently, two OCTbased approaches are explored for noninvasive glucometry in blood, based on signal attenuation [24][25][26] and correlation function analyses. 9,27,28 However, accuracy, robustness, and sensitivity/ specificity are currently insufficient for clinical implementations, for example, in diabetic patients use.…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, DLS OCT methodology measures coherent radiation scattered by an intact sample and holds promise for noninvasive measurement of fluid viscosity and potentially even in vivo glucose concentration measurements. 22 The present research thus has two objectives. First, we demonstrate DLS M-mode OCT measurements of backscattered radiation spectra to determine the viscosity of a suspending fluid with good accuracy and low uncertainty.…”

Section: Introductionmentioning

confidence: 99%

Accurate viscosity measurements of flowing aqueous glucose solutions with suspended scatterers using a dynamic light scattering approach with optical coherence tomography

2017

View full text Add to dashboard Cite

The viscosity of turbid colloidal glucose solutions has been accurately determined from spectral domain optical coherence tomography (OCT) M-mode measurements and our recently developed OCT dynamic light scattering model. Results for various glucose concentrations, flow speeds, and flow angles are reported. The relative "combined standard uncertainty" uc(η) on the viscosity measurements was ±1% for the no-flow case and ±5% for the flow cases, a significant improvement in measurement robustness over previously published reports. The available literature data for the viscosity of pure water and our measurements differ by 1% (stagnant case) and 1.5% (flow cases), demonstrating good accuracy; similar agreement is seen across the measured glucose concentration range when compared to interpolated literature values. The developed technique may contribute toward eventual noninvasive glucose measurements in medicine.

show abstract

Optical coherence tomography for glucose monitoring in blood

Cited by 18 publications

References 45 publications

Alternative Contrast Mechanism in Optical Coherence Tomography: Temporal Speckle Synchronization Effects

Alternative Contrast Mechanism in Optical Coherence Tomography: Temporal Speckle Synchronization Effects

Review of Emerging Approaches in Non- or Minimally Invasive Glucose Monitoring and their Application to Physiological Human Body Fluids

Accurate viscosity measurements of flowing aqueous glucose solutions with suspended scatterers using a dynamic light scattering approach with optical coherence tomography

Contact Info

Product

Resources

About