Optical coherence tomography findings in patients with alcohol use disorder and their relationship with clinical parameters

Özsoy, Filiz; Alim, Sait

doi:10.1080/15569527.2019.1700379

Cited by 13 publications

(13 citation statements)

References 29 publications

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“…However, a slightly more limited number of papers have studied addiction and OCT measurements. The results reported are contradictory [ 15 , 16 , 22 , 23 , 24 , 25 ]. In a study in which OCT measurements were measured in patients with alcohol use disorder, RNLF thicknesses were not different from those of healthy controls [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…The results reported are contradictory [ 15 , 16 , 22 , 23 , 24 , 25 ]. In a study in which OCT measurements were measured in patients with alcohol use disorder, RNLF thicknesses were not different from those of healthy controls [ 22 ]. In another study that was conducted with patients diagnosed with alcohol use disorder, all quadrants of trace RNLF were found to be thinner than those of healthy controls [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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OCT Findings in Patients with Methamphetamine Use Disorder

Kaya

Kaya²

2023

JPM

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Purpose: In the present study, the purpose was to examine the results of optical coherence tomography (OCT) measurements in patients diagnosed with methamphetamine use disorder (MUD) by comparing them with healthy controls. Materials and Methods: A total of 114 eyes were evaluated in this study (27 patients and 30 control group participants). After detailed biomicroscopic examinations of all participants by the same ophthalmologist, both eyes were evaluated by OCT. The retinal nerve fiber layer thickness (RNFL) and macular thickness were calculated from OCT. Results: No statistically significant differences were detected between the demographic data of the patient and control groups (p > 0.05). When OCT findings were evaluated, macular thickness and volume were not different between the groups (p > 0.05). With respect to RNFL, the left eye superior, inferior, temporal, and nasal quadrants, as well as the left eye’s total measurements were found to be thicker than those of controls (p < 0.05). In both eyes, the left eye nasal quadrant and APIS total score were negatively correlated, the total RNLF measurement of the right eye and APIS motivation subscale score were negatively correlated, central macular thickness and the APIS motivation subscale score were positively correlated, and the APIS substance use characteristics subscale score and left eye temporal quadrant RNLF measurement were positively correlated. Conclusion: Our study is the first to evaluate addiction severity and OCT findings in MUD. However, this study needs to be supported by further studies so that OCT findings, which can be used as an effective method for demonstrating possible neurodegeneration in methamphetamine use disorder, gain importance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

OCT Findings in Patients with Methamphetamine Use Disorder

Kaya

Kaya²

2023

JPM

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“…However, in clinical studies, there is still no conclusion on whether alcohol addiction causes damage to the retinal structure. Some determined that there were no statistically significant differences between the participants in retinal nerve fiber layer (RNFL) thickness, macular thickness, choroidal thickness, or ganglion cell-inner plexiform layer (GCIPL) thickness examined by Optical Coherence Tomography (OCT) ( Ozsoy and Alim, 2020 ). In contrast, some discovered that that alcohol consumption significantly reduced the RNFL and macular thickness ( Liu et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Although permanent vision impairment induced by intemperate consumption of alcohol is preventable, alcoholics do not usually perceive the functional damage to their eyes until clinical symptoms or organic diseases appear. Some studies indicate that chronic alcohol intake first induces functional disorders reflected in the decreased sensitivity of the visual cells and reduced conductivity of the optic nerve without causing anatomical changes within the retina and the optic nerve ( Ozsoy and Alim, 2020 ; Karimi et al, 2021 ). Therefore, establishing an effective method that can detect the functional deterioration of the visual pathway early is highly necessary for controlling alcoholic vision decline.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans: Clinical values in early prevention of alcoholic vision decline

Xie

Feng

Wang

et al. 2022

Front. Neural Circuits

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Alcohol addiction often compromises vision by impairing the visual pathway, particularly the retina and optic nerve. Vision decline in alcoholics consists of a sequential transition from reversible functional deterioration of the visual pathway to irreversible clinical vision degeneration or vision loss. Thus, the control of alcoholic vision decline should focus on prevention before permanent damage occurs. Visual electrophysiology is a promising method for early detection of retinal dysfunction and optic neuropathy, including full-field electroretinography (ffERG) and pattern-reversal visual evoked potential (PR-VEP). So far, however, research studying the electrophysiological characteristics in the preclinical stage of vision decline caused by alcohol addiction is still lacking. Here we conducted a retrospective study with 11 alcoholics and 14 matched control individuals to address this need. We had performed comprehensive visual electrophysiological tests, including ffERG and PR-VEP. We next analyzed all electrophysiological parameters using multivariate statistical analyses and discovered some highly sensitive alterations to alcohol addiction. We found severely reduced amplitudes in scotopic ffERG oscillatory potentials (OPs) in alcohol addicts. These changes indicate the alcohol-induced disturbances of amacrine cells and retinal circulation. In subjects with alcohol addiction, the amplitudes of b-waves diminish significantly in scotopic but not photopic ffERG, implying the impaired function of the retinal rod system and the dysfunction of the inner retina. PR-VEPs elicited by checkerboard stimuli with large 1 degree (°) checks mainly reflect the state of the optic nerve and ganglion cells, and PR-VEPs provoked by small 0.25° checks mainly reflect the function of the macular. We performed both measurements and observed a robust amplitude reduction in all three peaks (N75–P100, P100–N135) and a significant peak time extension in P100. Our research provides an affordable and non-invasive tool to accurately evaluate visual pathway conditions in alcohol addicts and help clinicians take targeted treatment.

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“…Visual pathways have been ideal detecting neurodegenerative processes (7) . Consequently, studies have been conducted to follow the changes in retinal nerve networks through optical coherence tomography (OCT) in recent years (8)(9)(10)(11) . Central macular thickness (CMT), mean macular thickness (MMT), mean macular volume (MMV) and retinal nerve fiber layer (RNFL) thickness can easily be measured through OCT (9) .…”

Section: Introductionmentioning

confidence: 99%