Optical coherence tomography angiography features of acute macular neuroretinopathy in dengue fever

Aggarwal, Kanika; Agarwal, Aniruddha; Katoch, Deeksha; Sharma, Mansi; Gupta, Vishali

doi:10.4103/ijo.ijo_485_17

Cited by 29 publications

(13 citation statements)

References 10 publications

(12 reference statements)

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“…Changes in OCTA in the SCP and DCP were noted in dengue and chikungunya retinitis. [678] Agarwal et al in their report on OCTA features of chikungunya retinitis reported that there were flow void areas in SCP, DCP, and choriocapillary slabs. [6] Aggarwal et al in their report on OCTA features of acute macular neuroretinopathy post-dengue fever noted flow deficit areas in SCP and DCP.…”

Section: Discussionmentioning

confidence: 99%

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Optical coherence tomography angiography features of retinitis post-rickettsial fever

Shanmugam

Konana

Ramanjulu

et al. 2019

Indian J Ophthalmol

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The intraocular manifestations of rickettisial retinitis include retinal vasculitis, maculopathy, optic neuritis, and neurosensory detachment. Extensive leakage of dye on the fundus fluorescein angiography may obscure visualization in eyes with retinitis. We report the vascular changes in eyes with rickettsial retinitis and its response to treatment using optical coherence tomography angiography. The microvascular abnormalities we noted were, capillary drop out areas corresponding to retinitis patches, vascular loops, and pruning of vessels. The choriocapillary slabs showed signal void areas. Post-treatment there was vascular remodeling with decrease in non-perfused area, appearance of new vascular lateral branching, and appearance of collaterals.

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Section: Discussionmentioning

confidence: 99%

“…They did not report any changes at the level of choriocapillary. [7] Bajgai et al noted broken foveal avascular zone in only SCP of OCTA in a case of dengue maculopathy and these changes persisted at follow-up visits. [8]…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography features of retinitis post-rickettsial fever

Shanmugam

Konana

Ramanjulu

et al. 2019

Indian J Ophthalmol

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“…3 Aggarwal et al and Liu and colleagues used OCTA to monitor improvement in retinal capillary disruption in patients with acute macular neuroretinopathy with and without treatment with oral steroids, respectively. 5,6 OCTA of our patient showed improvement in her superficial and deep capillary plexus deficits with a granularity finder than could be provided by FA months after treatment while her vision and other retinal lesions also improved. OCT was inadequate to monitor her posttreatment improvement of edema and accurately observe the degree of active ischemia and vasculitis.…”

Section: Discussionmentioning

confidence: 46%

“…5 OCTA may also be used to evaluate the impact of treatment on the restoration of blood flow. 6 We present the first reported case to our knowledge of mixed connective tissue disease (MCTD)-associated retinal vasculitis monitored by OCTA with findings characteristic of occlusive vasculitis that demonstrated improvement in pathologic blood flow over the course of systemic and local treatment.…”

Section: Introductionmentioning

confidence: 97%

Monitoring Ischemic Changes in Retinal Vasculitis With Optical Coherence Tomography Angiography

Dillon

Kovacs

Orlin

2019

Journal of VitreoRetinal Diseases

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Purpose: This article illustrates the ability of optical coherence tomography angiography (OCTA) to aid in the diagnostic workup and management of occlusive retinal vasculitis over time. Methods: A case presentation is discussed. Results: In this case, OCTA helped define the extent and evolution of superficial and deep retinal capillary plexus occlusion and reperfusion over the treatment course. Conclusions: OCTA detects blood flow and maps retinal vasculature at the capillary level without the use of intravenous dye. Serial image acquisition can reveal patterns of ischemia and reperfusion in retinal vascular conditions as they evolve and respond to therapy, providing more granular information regarding the status of the retinal microvasculature that may guide treatment.

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“…Dengue fever, an arthropod-borne disease, caused by four serotypes of Dengue virus, can manifest various ophthalmologic symptoms, such as subconjunctival hemorrhage, keratitis, anterior uveitis, angle-closure glaucoma as for anterior segment and, more commonly, ME, retinal hemorrhages, foveolitis, cotton wool spots, AMN lesions, and microaneurysms as for posterior segment involvement [98]. Deduced from case reports, OCTA has proven to be a worthy diagnostic tool for detecting flow deficits in the perifoveal region within the DCP and SCP in ischemic inflammatory foveolitis and outer maculopathy, even when fundus lesions were not detectable [98–100].…”

Section: About the Implementation Of Optical Coherence Tomography Angmentioning

confidence: 99%

Optical coherence tomography angiography (OCTA) as a new diagnostic tool in uveitis

Dingerkus

Munk

Brinkmann

et al. 2019

J Ophthal Inflamm Infect

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Background The broad spectrum of uveitis disorders requires a multimodal imaging approach in the daily practice of an ophthalmologist. As inflammatory conditions, they have in common an alteration in leukocyte migration. In this context, optical coherence tomography angiography (OCTA) might be of great value for diagnosing or following up patients with these disorders. To date, OCTA has rather been used as an additional tool besides the well-established diagnostic imaging tools, but its complementary diagnostic features become increasingly relevant, to follow disease activity and treatment response and for the understanding of pathomechanisms of various uveitis types. This review summarizes the possible applications of OCTA and its advantages and disadvantages as opposed to dye-based angiographies in uveitic diseases. Main body Hitherto gold standards in the diagnostic workup of posterior or intermediate uveitis have been angiography on a dye-based method, which is fluorescein or indocyanine green. It gives information about the status of the blood-retinal barrier and the retinal and choroidal vasculature by visualizing diffuse leakage as a state of inflammation or complications as an ischemia or choroidal neovascularization. As noninvasive methods, fundus autofluorescence depicts the status of metabolic activity of the retinal pigment epithelium and OCT or enhanced depth imaging OCT, respectively, as a depth-resolving imaging method can supply additional information. OCTA as a non-invasive, depth-resolution imaging tool of retinal and choroidal vessels adds detailed qualitative and quantitative information of the status of retinal and choroidal vessels and bridges the gap between the mentioned conventional diagnostic tools used in uveitis. It is important, though, to be aware of its limitations, such as its susceptibility to motion artifacts, limited comparability among different devices, and restricted contribution of information regarding the grade of disease activity. Conclusion OCTA as a non-invasive, depth-resolution imaging tool can give qualitative and quantitative information about the status of retinal and choroidal vessels, but also has certain limitations. Employing OCTA as a complementary rather than exclusive tool, it can give important additional information about the macro- and microvasculature under inflammatory circumstances. Thereby, it also contributes to the understanding of the pathophysiology of various uveitis entities.

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Optical coherence tomography angiography features of acute macular neuroretinopathy in dengue fever

Cited by 29 publications

References 10 publications

Optical coherence tomography angiography features of retinitis post-rickettsial fever

Optical coherence tomography angiography features of retinitis post-rickettsial fever

Monitoring Ischemic Changes in Retinal Vasculitis With Optical Coherence Tomography Angiography

Optical coherence tomography angiography (OCTA) as a new diagnostic tool in uveitis

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