Optical Coherence Tomography

Huang, David; Swanson, Eric A.; Lin, Charles P.; Schuman, Joel S.; Stinson, William G.; Chang, Warren; Hee, Michael R.; Flotte, Thomas; Gregory, Kenton W.; Puliafito, Carmen A.; Fujimoto, James G.

doi:10.1126/science.1957169

Cited by 12,570 publications

(7,404 citation statements)

References 32 publications

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“…26,29,30 The thinning observed in the RNFL inferior quadrant in patients with OH confirms previous observations, 31 although with a different percentage incidence that may be owing to the analysis method used. [32][33][34][35] This localized thinning of the RNFL might be an early sign of glaucoma 36 before any signs of optic nerve disorders or visual field impairment appear.…”

Section: Discussionsupporting

confidence: 85%

“…24,25 OCT is an optical analogue of an ultrasound B-scan that can create cross-section images of the RNFL in both the axial and lateral dimensions. 26 As OCT is based on near-infrared interferometry, the thickness measured is not affected by refractive status or axial length of the eye nor by changes in nuclear cataract density. However, cortical cataracts, heavy nuclear cataracts, secondary cataracts, poor vitreous body transparency, and silicon oil in the posterior chamber 27,28 may affect measurement accuracy.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 The quantitative investigation techniques proposed for the study of the RNFL are scanning laser polarimetry (SLP), 3,4 Heidelberg retinal tomography (HRT), 5,6 and more recently optical coherence tomography (OCT). OCT is a technique that makes it possible to examine high-resolution cross-sections of ocular tissues using the low coherence interferometry principle [7][8][9][10] and it seems more reliable than SLP and HRT in the study of RNFL. 11,12 It is particularly important to use high-quality investigation techniques in the study of glaucoma patients to facilitate early detection of functional deterioration owing to the irreversible nature of the retinal ganglion cell loss and axonal damage.…”

Section: Introductionmentioning

confidence: 99%

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Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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Purpose To study in ocular hypertension (OH) the retinal nerve fibre layer (RNFL) with optical coherence tomography (OCT) and the neuronal function with frequency-doubling technology (FDT) to assess which of the two methods was more sensitive in detecting early glaucomatous damage. Furthermore, a colour Doppler imaging (CDI) of the optic nerve was carried out to highlight any correlation with RNFL thickness and FDT abnormality. Materials and methods We enrolled 28 ocular hypertensive patients who underwent OCT of the RNFL and FDT. Moreover, we performed a CDI of the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCAs). Results The patients with OH following OCT revealed a significant thinning in the RNFL as compared to the control group only in the inferior quadrant: 122.250714.091 vs 131.750710.729 lm (Po0.045). As regards FDT, there was a significant difference between the two groups only for pattern standard deviation (PSD): 3.87371.488 vs 1.93870.704 dB (Po0.044). In OH and in the control group, CDI resistance index (RI) in the OA was 0.76870.012 vs 0.74570.019 (Po0.022), in the CRA was 0.6670.012 vs 0.64570.019 (Po0.032), and in PCAs was 0.67370.039 vs 0.62270.012 (Po0.037). The OCT had a sensitivity of 83% but only in the inferior RNFL quadrant. The FDT-PSD revealed a sensitivity of 85%. Conclusions Both FDT and OCT detect early glaucomatous damage with a slightly superior sensitivity of FDT vs OCT. The CDI measurements suggest that circulatory abnormalities may have a role in the development of OCT and FDT damage.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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“…OCT is a technique that allows the acquisition of three‐dimensional images from optical scattering media at a micrometer resolution 49, 50. By combining such an optical technique with electrochemical analyses, quantitative data with high temporal resolution can be obtained.…”

Section: Introductionmentioning

confidence: 99%

In situ Biofilm Quantification in Bioelectrochemical Systems by using Optical Coherence Tomography

Molenaar

Sleutels²,

Pereirã³

et al. 2018

ChemSusChem

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Detailed studies of microbial growth in bioelectrochemical systems (BESs) are required for their suitable design and operation. Here, we report the use of optical coherence tomography (OCT) as a tool for in situ and noninvasive quantification of biofilm growth on electrodes (bioanodes). An experimental platform is designed and described in which transparent electrodes are used to allow real‐time, 3D biofilm imaging. The accuracy and precision of the developed method is assessed by relating the OCT results to well‐established standards for biofilm quantification (chemical oxygen demand (COD) and total N content) and show high correspondence to these standards. Biofilm thickness observed by OCT ranged between 3 and 90 μm for experimental durations ranging from 1 to 24 days. This translated to growth yields between 38 and 42 mgCODbiomass gCODacetate −1 at an anode potential of −0.35 V versus Ag/AgCl. Time‐lapse observations of an experimental run performed in duplicate show high reproducibility in obtained microbial growth yield by the developed method. As such, we identify OCT as a powerful tool for conducting in‐depth characterizations of microbial growth dynamics in BESs. Additionally, the presented platform allows concomitant application of this method with various optical and electrochemical techniques.

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“…4,5 Since the predictability of refractive outcome is based on the accuracy of preoperative biometry, the methods used in biometry continue to evolve. [6][7][8][9][10][11][12] Preoperative biometry performed using A-scan ultrasonography uses the echo delay time to measure intraocular distances. It has a longitudinal resolution of 200 m and an accuracy of 100-120 m in measuring axial lengths.…”

mentioning

confidence: 99%

Partial coherence laser interferometry vs conventional ultrasound biometry in intraocular lens power calculations

Rajan

Keilhorn

Bell

2002

Eye

186

136

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Aims The purpose of the study was to compare optical biometry based on partial coherence laser interferometry (PCLI) principle to conventional ultrasound biometry in the accuracy of intraocular lens (IOL) power calculations. The role of partial coherence laser interferometry in pseudophakic axial length measurement was analysed in the study. Methods In a prospective randomised clinical trial, 100 patients undergoing phacoemulsification cataract surgery were randomised to undergo biometry by either partial coherence laser interferometry (IOL Master) or the applanation ultrasound technique. The IOL material, design and the IOL formula were standardized. The mean error and mean absolute error were calculated and compared using paired t-tests. Results One hundred patients were included in this prospective randomised trial, of whom 50 patients underwent optical biometry and 50 patients had biometry by applanation ultrasound. The mean age of patients in the PCLI group was 67 ± 6 yrs as compared to 71 ± 8 yrs in the ultrasound group (P Ͼ 0.

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Optical Coherence Tomography

Cited by 12,570 publications

References 32 publications

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

In situ Biofilm Quantification in Bioelectrochemical Systems by using Optical Coherence Tomography

Partial coherence laser interferometry vs conventional ultrasound biometry in intraocular lens power calculations

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