Optical Biosensing and Bioimaging With Porous Silicon and Silicon Quantum Dots (Invited Review)

Guan, Bin

doi:10.2528/pier17120504

Cited by 23 publications

(9 citation statements)

References 123 publications

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“…From a practical point of view, the readers can refer to Sailor’s book, Porous Silicon in Practice , which includes theoretical data, protocols and instructions regarding PSi preparation and characterization methods, surface chemistry, and applications. Other research groups have reviewed the field of PSi-based biosensors in terms of basic principles and sensing mechanisms of PSi sensors and biosensors, ,− surface chemistry, ,− target analytes, , and sensing applications. − Zhang has published a thorough review on diverse formation mechanisms of PSi and the resulting morphological features. The Gooding research group has issued an excellent review on recent advancements in microfabrication and modification of PSi substrates and PSi microparticles for multiplexed optical assays .…”

Section: Books Reviews and Articles Of General Interestmentioning

confidence: 99%

Porous Silicon-Based Photonic Biosensors: Current Status and Emerging Applications

et al. 2018

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Section: Books Reviews and Articles Of General Interestmentioning

confidence: 99%

Porous Silicon-Based Photonic Biosensors: Current Status and Emerging Applications

et al. 2018

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“…As the 3D size of silicon shrinks, nanocrystals called silicon quantum dots (Si-QDs) are gradually produced. [1] Traditional quantum dots are usually made of known toxic (such as Cd) heavy metal materials, which urgently needs a substitute with higher biosafety. Unlike traditional quantum dots, Si-QDs are unique biocompatible luminous bodies with a narrow luminescence band.…”

Section: Introductionmentioning

confidence: 99%

Low‐Cost Water Soluble Silicon Quantum Dots and Biocompatible Fluorescent Composite Films

Guoqian

Qiu³

et al. 2021

Part & Part Syst Charact

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Si-QDs are ultrasmall crystals with the size of only a few nanometers. [10] Based on the original properties of silicon materials, they also possess the unique fluorescence properties of QDs. Compared with traditional organic fluorescent materials, these quantum dots have good electronic properties, large surface-to-volume ratio, [11][12][13] size-dependent and tunable fluorescence emission, increased interband transition probability and high stability for photobleaching, [14][15][16] which make them potential options for the next generation optoelectronic devices, solar cells, and fluorescent biological imaging/sensing reagents. [17,18] In addition, luminescent silicon nanoparticles are chemically engineered to become specific probes to accumulation at sites of interest for labeling and imaging. [19] Generally speaking from the synthesis principle, [20][21][22] there are three classes of methods for manufacturing Si-QDs, such as the top-down methods, the bottom-up methods, and a combination of both. As the name suggests, the top-down method is the decomposition of large pieces of silicon into small nanocrystals. [23] The most common method is based on acid-based etching or electrochemical potential, the advantage of which is that these methods provide good color adjustability by controlling the particle size. In contrast, the bottom-up method uses the principle of self-assembly to construct nanocrystals from smaller chemical components. The construction process of this method is similar to that of traditional quantum dot manufacturing technology and the process is relatively mature. It is worth mentioning that since Raj and his colleagues first reported the synthesis of thiol-terminated cadmium telluride quantum dots in aqueous solution in 1993, most of the work on the synthesis of quantum dots has focused on environmentally friendly, and low-cost methods, which can be directly applied to the hydrothermal method for biological research. [24] Recently, research work on fluorescent polymers such as quantum dots has focused on encapsulating fluorescent materials and realizing their fictionalization and device application. [25,26] Quantum dots can be compounded with other polymers with special functions to form a new type of material. This way of combining the two through physical or chemical means endows the composite material with excellent performance, attracting worldwide attention. So far, there has been much research on semiconductor quantum dots and functional polymer composite materials. These reports also demonstrate great application potential in the fields of photoelectric Silicon quantum dots (Si-QDs) with the advantages of excellent biocompatibility, rich sources of raw materials, and low synthesis cost, are attracting enormous attention as ideal candidates for replacing existing semiconductor quantum dot products. The water-soluble fluorescent Si-QDs and the Si-QDs/Chitosan composite material are successfully prepared here by combined microwave-assisted and traditional one-step hydrothermal synthesis u...

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“…Recent reviews on the utilization of SiQDs in bioimaging and biosensing (Cheng et al, 2014;McVey and Tilley, 2014;Cheng and Guan, 2017;Ji et al, 2018), solar cells (Chen and Yang, 2015), nonlinear optics (Bisadi et al, 2015), and photonics (Priolo et al, 2014;Zhao et al, 2018) show the broad interest and scope of the research concerning these nanomaterials. Less attention has been paid to the features of Si quantum dot-based light-emitting diodes (LEDs), even though in principle one of the most valuable applications of said quantum dots would be in making new LEDs based on abundant silicon in place of current commercial LEDs, which are based on rare earths or on organic phosphors (Buckley et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Silicon Quantum Dots: Synthesis, Encapsulation, and Application in Light-Emitting Diodes

et al. 2020

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Silicon quantum dots (SiQDs) are semiconductor Si nanoparticles ranging from 1 to 10 nm that hold great applicative potential as optoelectronic devices and fluorescent bio-marking agents due to their ability to fluoresce blue and red light. Their biocompatibility compared to conventional toxic Group II-VI and III-V metal-based quantum dots makes their practical utilization even more attractive to prevent environmental pollution and harm to living organisms. This work focuses on their possible use for light-emitting diode (LED) manufacturing. Summarizing the main achievements over the past few years concerning different Si quantum dot synthetic methods, LED formation and characteristics, and strategies for their stabilization by microencapsulation and modification of their surface by specific ligands, this work aims to provide guidance en route to the development of the first stable Si-based light-emitting diodes.

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Optical Biosensing and Bioimaging With Porous Silicon and Silicon Quantum Dots (Invited Review)

Cited by 23 publications

References 123 publications

Porous Silicon-Based Photonic Biosensors: Current Status and Emerging Applications

Porous Silicon-Based Photonic Biosensors: Current Status and Emerging Applications

Low‐Cost Water Soluble Silicon Quantum Dots and Biocompatible Fluorescent Composite Films

Silicon Quantum Dots: Synthesis, Encapsulation, and Application in Light-Emitting Diodes

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