Optical atomic magnetometer at body temperature for magnetic particle imaging and nuclear magnetic resonance

Abstract

Optical atomic magnetometers are often bulky and operate at elevated temperatures that impose restrictions on studying biological samples. Here we report a miniaturized Cs-based magnetometer, in contrast to conventionally used K- and Rb-based ones, with high sensitivity. The magnetic shield employed is more compact, and the optimal operation temperature of 37 degrees C is lower than previous magnetometers and is suitable for biological research. Applications include scanning magnetic imaging of functionalized magnetic particles and nuclear magnetic resonance of water. We reveal that the stability and sensitivity of the apparatus are not significantly affected by the absence of a laser stabilization device.

Scanning Imaging of Magnetic Nanoparticles for Quantitative Molecular Imaging

“…The atomic magnetometer has a sensitivity of about 150 fT/(Hz) 1/2 . [16] The motion of the samples was achieved by using an automated linear actuator for x-axis scans and a pair of motorized positioning stages for d-axis movements. The magnetic field was measured with an integration time of 30 ms for each data point.…”

Scanning Imaging of Magnetic Nanoparticles for Quantitative Molecular Imaging

“…[16] The motion of the samples was achieved by using an automated linear actuator for x-axis scans and a pair of motorized positioning stages for d-axis movements. The magnetic field was measured with an integration time of 30 ms for each data point.…”

Detection of magnetic nanomaterials in molecular imaging and diagnosis applications

“…The combination of approximately 20 μm resolution, nearly 1 cm detection distance, and picoliter-range detection limit makes this technique uniquely suited for practical applications of MNP in molecular imaging [162]. In addition, the AM used in this work had an operation temperature of 37°C, which is compatible with biomedical assay analysis and in vivo imaging [163]. With further development, two-dimensional scanning magnetic imaging of arbitrarily oriented MNP and quantitative molecular imaging of targeted antibody were demonstrated [164].…”