Optical and Electrochemical Study of Acridine‐Based Polyaza Ligands for Anion Sensing

Bettazzi, Francesca; Voccia, Diego; Bencini, Andrea; Giorgi, Claudia; Palchetti, Ilaria; Valtancoli, Barbara; Conti, Luca

doi:10.1002/ejic.201800298

Cited by 16 publications

(9 citation statements)

References 33 publications

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“…Analogously to that reported for similar polyammonium scaffolds, this effect could be rationalized with the increase in the protonation state of the, polyamino‐macrocycle residue on lowering the pH. The consequent formation of a more distorted excited‐state geometry of the molecule, which favors radiationless processes might be responsible for the poor emissive species revealed for low pH values.…”

Section: Resultsmentioning

confidence: 99%

Highly Charged Ruthenium(II) Polypyridyl Complexes as Effective Photosensitizer in Photodynamic Therapy

Conti

Bencini

Ferrante

et al. 2019

Chemistry A European J

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A comparative study between two novel, highly water soluble, ruthenium(II) polypyridyl complexes, [Ru(phen)2L′] and [Ru(phen)2Cu(II)L′] (L and L‐CuII), containing the polyaazamacrocyclic unit 4,4′‐(2,5,8,11,14‐pentaaza[15])‐2,2′‐bipyridilophane (L′), is herein reported. L and L‐CuII interact with calf‐thymus DNA and efficiently cleave DNA plasmid when light‐activated. They also possess great penetration abilities and photo‐induced biological activities, evaluated on an A375 human melanoma cell line, with L‐CuII being the most effective. Our study highlights the key role of the Fenton active CuII center within the macrocycle framework, that would play a synergistic role with light activation in the formation of cytotoxic ROS species. Based on these results, an optimal design of RuII polypyridyl systems featuring specific CuII‐chelating polyamine units could represent a suitable strategy for the development of novel and effective photosensitizers in photodynamic therapy.

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Section: Resultsmentioning

confidence: 99%

Highly Charged Ruthenium(II) Polypyridyl Complexes as Effective Photosensitizer in Photodynamic Therapy

Conti

Bencini

Ferrante

et al. 2019

Chemistry A European J

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“…While these examples, and a majority of electrochemical sensors in general, are prepared by self-assembly on gold electrodes, impedimetric anion sensing has also been carried out at other interfaces. In a recent report, two polyaza-acridine receptors were immobilized on screen printed carbon electrodes by voltammetric deposition (potential cycling), enabling impedimetric sensing of SeO 3 2– in the presence of Fe(CN) 6 3–/4– …”

Section: Impedimetric and Capacitive Anion Sensing In Molecular Filmsmentioning

confidence: 99%

Electrochemical Anion Sensing: Supramolecular Approaches

2020

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Anions play a vital role in a broad range of environmental, technological, and physiological processes, making their detection/quantification valuable. Electroanalytical sensors offer much to the selective, sensitive, cheap, portable, and real-time analysis of anion presence where suitable combinations of selective (noncovalent) recognition and transduction can be integrated. Spurred on by significant developments in anion supramolecular chemistry, electrochemical anion sensing has received considerable attention in the past two decades. In this review, we provide a detailed overview of all electroanalytical techniques that have been used for this purpose, including voltammetric, impedimetric, capacititive, and potentiometric methods. We will confine our discussion to sensors that are based on synthetic anion receptors with a specific focus on reversible, noncovalent interactions, in particular, hydrogen-and halogen-bonding. Apart from their sensory properties, we will also discuss how electrochemical techniques can be used to study anion recognition processes (e.g., binding constant determination) and will furthermore provide a detailed outlook over future efforts and promising new avenues in this field.

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“…The easy and universal application of PDA and the wide variety of exploitation in sensing and biosensing assays development is in contrast with the complex electrochemical behavior. Moreover, this is also in contrast to the well-established redox processes of common conducting polymers, such as polypyrrole, polythiophene, or polyaniline [73,74].…”

Section: Deposition Of a Polydopamine Layer On An Electrode: Chemicalmentioning

confidence: 89%

Polydopamine: surface coating, molecular imprinting, and electrochemistry—successful applications and future perspectives in (bio)analysis

2019

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Dopamine oxidation and self-polymerization has recently gained a large interest arising from the versatile chemistry of this endogenous catecholamine. Particularly stimulating appear the applications of this biopolymer for surface coating, molecular imprinting, and electrochemistry, here reviewed, covering the broad fields of medicine, material science, and (bio)analytical chemistry.Nonetheless, the peculiar physicochemical properties of dopamine and its polymer, due to the reduction potential of catechol moiety, are not fully exploited. We have confidence in possibility to spread its applications through a large variety of research approaches, including the use of naturally occurring or synthetic dopamine analogues and co-polymers. Accordingly, our efforts in this direction are focused in proposing the role of this polymer for quantitative applications, evaluating analytical performances, costs, reproducibility and versatility of the developed methods also revisiting standard (bio)analytical platforms.

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Optical and Electrochemical Study of Acridine‐Based Polyaza Ligands for Anion Sensing

Cited by 16 publications

References 33 publications

Highly Charged Ruthenium(II) Polypyridyl Complexes as Effective Photosensitizer in Photodynamic Therapy

Highly Charged Ruthenium(II) Polypyridyl Complexes as Effective Photosensitizer in Photodynamic Therapy

Electrochemical Anion Sensing: Supramolecular Approaches

Polydopamine: surface coating, molecular imprinting, and electrochemistry—successful applications and future perspectives in (bio)analysis

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