Optical and Electrochemical Sensors and Biosensors for the Detection of Quinolones

Majdinasab, Marjan; Mitsubayashi, Kohji; Marty, Jean Louis

doi:10.1016/j.tibtech.2019.01.004

Cited by 120 publications

(45 citation statements)

References 73 publications

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“…Electrochemical sensors are the commonly-used devices for in vitro continuous measurements in the sample matrixes include buffer, serum, plasma, and whole blood. Electrochemical biosensors analyse the content of a biological sample through the direct conversion of a biological event into an electronical signal via an electrochemical transductor [ 31 , 32 ]. An electrochemical system comprises a three-electrode sensing cell in direct contact with the target solution, and a potentiostat to drive the measurements and read out the signal [ 33 ].…”

Section: In Vitro Biosensing Technologies For Continuous Drug Monitormentioning

confidence: 99%

Towards wearable and implantable continuous drug monitoring: A review

Bian

Zhu

Rong

et al. 2021

Journal of Pharmaceutical Analysis

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Continuous drug monitoring is a promising alternative to current therapeutic drug monitoring strategies and has strong potential to reshape our understanding of pharmacokinetic variability and to improve individualised therapy. This review highlights recent advances in biosensing technologies that support continuous drug monitoring in real time. We focus primarily on aptamer-based biosensors, wearable and implantable devices. Emphasis is given to the approaches employed in constructing biosensors. We pay attention to sensors’ biocompatibility, calibration performance, long-term characteristics stability and measurement quality. In the end, we discuss about the current challenges and issues to address in continuous drug monitoring to make it a promising, future tool for individualised therapy. The ongoing efforts are expected to result in fully integrated implantable drug biosensing technology. Thus, we may anticipate an era of advanced healthcare in which wearable and implantable biochips automatically adjust drug dosing in response to patient health conditions enabling the management of diseases and enhancing individualised therapy.

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Section: In Vitro Biosensing Technologies For Continuous Drug Monitormentioning

confidence: 99%

Towards wearable and implantable continuous drug monitoring: A review

Bian

Zhu

Rong

et al. 2021

Journal of Pharmaceutical Analysis

View full text Add to dashboard Cite

show abstract

“…As a remarkable example, we mention that electrochemical methods allow a signal that is proportional to the analyte concentration to be obtained, thus guaranteeing easy-to-calibrate sensors in a simple configuration. However, lowering the limit of detection is the major goal in the realization of electrochemical sensors, while rapid response-time, low-cost, ease of operation and potential for miniaturization have already been achieved [5].…”

Section: Introductionmentioning

confidence: 99%

“…Even though they are endowed with different characteristics, biosensors based on electrochemical and optical methods can aim at becoming powerful and robust analytical tools: nanostructuring the sensing active region for amplifying the collected signal and/or implementing functional nanomaterials for increasing analyte specificity are considered valuable strategies [3,5].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Organic/Hybrid Materials and Components in Miniaturized Optical and Chemical Sensors

et al. 2020

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In the last decade, biochemical sensors have brought a disruptive breakthrough in analytical chemistry and microbiology due the advent of technologically advanced systems conceived to respond to specific applications. From the design of a multitude of different detection modalities, several classes of sensor have been developed over the years. However, to date they have been hardly used in point-of-care or in-field applications, where cost and portability are of primary concern. In the present review we report on the use of nanostructured organic and hybrid compounds in optoelectronic, electrochemical and plasmonic components as constituting elements of miniaturized and easy-to-integrate biochemical sensors. We show how the targeted design, synthesis and nanostructuring of organic and hybrid materials have enabled enormous progress not only in terms of modulation and optimization of the sensor capabilities and performance when used as active materials, but also in the architecture of the detection schemes when used as structural/packing components. With a particular focus on optoelectronic, chemical and plasmonic components for sensing, we highlight that the new concept of having highly-integrated architectures through a system-engineering approach may enable the full expression of the potential of the sensing systems in real-setting applications in terms of fast-response, high sensitivity and multiplexity at low-cost and ease of portability.

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“…Optical sensors have several applications in various fields, such as medicine, chemistry, biology, health, and safety requiring compact, reliable, and yet cost-effective optical devices [1][2][3][4]. Due to the high accuracy, the sensitivity of recognition, and detection of chemical products, optical gas sensors have been extensively investigated in the field of chemistry [5][6][7]. Poisonous and dangerous gases in an atmosphere exposing human health to danger and even leading to the casualties are increasingly revealing the need for the highly sensitive optical sensors to detect toxic gases [8].…”

Section: Introductionmentioning

confidence: 99%

Polarization-Insensitive Hybrid Plasmonic Waveguide Design for Evanescent Field Absorption Gas Sensor

2020

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We propose a polarization-insensitive design of a hybrid plasmonic waveguide (HPWG) optimized at the 3.392 µm wavelength which corresponds to the absorption line of methane gas. The waveguide design is capable of providing high mode sensitivity (Smode) and evanescent field ratio (EFR) for both transverse electric (TE) and transverse magnetic (TM) hybrid modes. The modal analysis of the waveguide is performed via 2-dimension (2D) and 3-dimension (3D) finite element methods (FEMs). At optimized waveguide parameters, Smode and EFR of 0.94 and 0.704, can be obtained for the TE hybrid mode, respectively, whereas the TM hybrid mode can offer Smode and EFR of 0.86 and 0.67, respectively. The TE and TM hybrid modes power dissipation of ~3 dB can be obtained for a 20-µm-long hybrid plasmonic waveguide at the 60% gas concentration. We believe that the highly sensitive waveguide scheme proposed in this work overcomes the limitation of the polarization controlled light and can be utilized in gas sensing applications.

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Optical and Electrochemical Sensors and Biosensors for the Detection of Quinolones

Cited by 120 publications

References 73 publications

Towards wearable and implantable continuous drug monitoring: A review

Towards wearable and implantable continuous drug monitoring: A review

Nanostructured Organic/Hybrid Materials and Components in Miniaturized Optical and Chemical Sensors

Polarization-Insensitive Hybrid Plasmonic Waveguide Design for Evanescent Field Absorption Gas Sensor

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