Optic neuritis in children: Recurrence and subsequent development of multiple sclerosis

Visudhiphan, Pongsakdi; Chiemchanya, Surang; Santadusit, Satit

doi:10.1016/0887-8994(95)00188-3

Cited by 32 publications

(20 citation statements)

References 19 publications

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“…The lesion was considered monofocal despite the fact that the signs are poly symptomatic and so no direct comparison could be made with these findings. When the presenting symptoms were analyzed 29% of our patients presented with optic neuritis (unilateral or bilateral) compared to only 10%-23% reported by Banwell et al, [5] Renoux et al, [8] and Simone et al [4] but they were consistent with the findings of Visudhiphan et al [18] and Mikaeloff et al [14] that optic neuritis was commonly the first sign in Asia. It is also consistent with the figure given by Stephen [17] for MS in the general population.…”

Section: Discussionsupporting

confidence: 92%

The course of early-onset multiple sclerosis in Iraqi children

2011

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Section: Discussionsupporting

confidence: 92%

The course of early-onset multiple sclerosis in Iraqi children

2011

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“…9,11 However, the rate of developing MS after pediatric optic neuritis also varied with race (Table 4). In comparison with other Asian countries, the rate of developing MS was 12.5% in our study, which was higher than Korean (4%), 15 and Thai (9.1%), 14 but was much lower than that reported in Japanese (31.7%), 17 and another recent Korean study (25%). 19 One of the reasons for wide range of conversion rate in each study might be due to different follow-up period.…”

Section: Discussioncontrasting

confidence: 46%

“…8,11,12,14,15,17,19 According to these reports, 77-90% of patients attained final VA of 20/40 or better. In addition, optic neuritis in childhood had more bilateral, female involvement, disc swelling at presentation, and was frequently associated with preceding viral infection.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] However, there have been accumulating reports with different clinical characteristics of optic neuritis and MS in Europe, 11,12 North America, 8,9,13 and Asia. [14][15][16][17] Herein we report a retrospective study to evaluate the clinical characteristics of children with optic neuritis in Taiwan. Meanwhile, the specific aim of this study was to statistically document the factors relevant to visual prognosis in optic neuritis in children.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of optic neuritis in Taiwanese children

Sun

et al. 2011

Eye

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“…Such an early presentation is increasingly been reported. Visudhiphan et al 9 reported cases between 1-2 years of age. The female to male ratio of our study patients was 0.47.…”

Section: Discussionmentioning

confidence: 99%

Clinical Spectrum of Pediatric Optic Neuritis in Indian Children

Singh¹,

Phuljhele²,

Sharma³

et al. 2017

Ophthalmol Open J

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Purpose: To study the clinical spectrum of pediatric optic neuritis in Indian children at a tertiary care centre. Methods: A retrospective study of patients diagnosed with optic neuritis below 20 years of age at a tertiary care centre in India over a 3 year period were reviewed. The ophthalmological examination findings, Goldmann perimetry, electrophysiological tests and magnetic resonance imaging (MRI) were reviewed. Results: The study reviewed 28 patients (44 eyes) and found a mean age of 12.6±4.9 years (2-20 years) having a follow-up record for a mean period of 6.3±4.9 months (0.3-38 months). 32.1% were females (F: M-0.47). Six patients (20.7%) had a viral prodrome and 12 (42.9%) complained of painful ocular movements. The mean baseline visual acuity (VA) was 1.80±0.6 logMAR units (Range=0.2-3.0 logMAR units) and the last best visual acuity was 0.43±0.4 log MAR units (Range=0-1.79 logMAR units). Thirty six eyes (81.8%) had a visual acuity at or below 3/60 and 40 eyes (90.9%) of 6/60 or lower of the snellen chart at the time of presentation. The mean contrast sensitivity at presentation was 1.02±0.46 (range=0-1.65). 16 pts (57.1%) had a bilateral presentation and 20 patients (71.4%) had either unilateral or bilateral papillitis. All the patients were given pulse dexamethasone (3-5 mg/kg/d) for three consecutive days followed by oral prednisolone (1-1.5 mgKg/day) for 11 days. At 1 week, 21 out of 44 eyes (47.7%) had a visual acuity ≥6/18 of the snellen chart. Three patients showed demyelination suggestive of multiple sclerosis (MS) on MRI brain and were diagnosed as probable MS. A total of 9 eyes (20.5%) of 6 patients (20.7%) had a recurrence. Those below 10 years of age presented more commonly with papillitis compared to teenagers (p value=0.01). All the parameters were similar in males and females. Conclusion: Pediatric optic neuritis patients are associated with a good visual outcome and a faster recovery. There are no gender differences in either the presentation or the visual recovery. Papillitis was more often seen in the children below 10 years of age. None of the patients developed clinically definite multiple sclerosis.

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Optic neuritis in children: Recurrence and subsequent development of multiple sclerosis

Cited by 32 publications

References 19 publications

The course of early-onset multiple sclerosis in Iraqi children

The course of early-onset multiple sclerosis in Iraqi children

Clinical characteristics of optic neuritis in Taiwanese children

Clinical Spectrum of Pediatric Optic Neuritis in Indian Children

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