Clinical characteristics of optic neuritis in Taiwanese children

Optic Neuritis in Korean Children: Low Risk of Subsequent Multiple Sclerosis

“…Sun et al reported that optic neuritis in Taiwanese children showed a favorable outcome with a ow risk of multiple sclerosis (12.5%); acute disseminated encephalomyelitis was the most commonly associated systemic disease. 19 Sri-udomkajorn et al demonstrated the low risk of multiple sclerosis (6.5%) after childhood optic neuritis in Thailand. 20 A study of optic neuritis in Japanese children reported that 32% of patients with optic neuritis progressed to multiple sclerosis, 18 higher than reported frequencies in other Asian children (Table 3).…”

“…7 The reported conversion rate of pediatric optic neuritis to multiple sclerosis has varied been 6% and 36%. 6,7,[16][17][18][19][20] The incidence of multiple sclerosis in Korea is 0.1 per 100,0000. 11 The association of multiple sclerosis and adult optic neuritis in Korea is not known.…”

Pediatric Optic Neuritis

“…9,10 One third of patients will have optic disc edema (papillitis) with the remaining patients presenting with a normal appearing optic disc (retrobulbar ON). [14][15][16][17][19][20][21][23][24][25][27][28][29][30][31][32][33][34][35][36] A small percentage of children (4% to 28%) recover to a vision of <20/ 200 [14][15][16][17][19][20][21]23,25,[27][28][29][31][32][33][34][35][36] and 5% have a vision of 20/50 to 20/100 (Table 1). [11][12][13] In children, the exact timing of visual loss can be difficult to determine because a precise medical history often cannot be obtained.…”

“…Depending on the study, the reported rate of conversion of pediatric ON to CDMS ranges from 0% to 33% 14,15,[17][18][19][20][21][22][24][25][26][27][28][29][30][31][32][33][34][35][36] (Table 1). Depending on the study, the reported rate of conversion of pediatric ON to CDMS ranges from 0% to 33% 14,15,[17][18][19][20][21][22][24][25][26][27][28][29][30][31][32][33][34][35][36] (Table 1).…”

“…The rate of conversion to CDMS was 13% at 10 years, 19% by 20 years, 22% by 30 years, and 26% by 40 years. [14][15][16][17]19,21,25,28,30,31,33,36 Mikaeloff and colleagues studied 296 patients after a first demyelinating clinical episode [a.k.a. 26 In an apparent contradiction, other older studies have suggested unilateral pediatric ON is a risk factor for the future development of CDMS.…”