Optic Nerve Head Extracellular Matrix in Primary Optic Atrophy and Experimental Glaucoma

Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma

“…(Hernandez 2000; Morrison 2006) This was initially demonstrated in non-human primates with experimental glaucoma, where deposits of collagen and other extracellular matrix (ECM) materials were found within laminar pores. (Morrison et al 1990) Similar deposits were later described in rat eyes with chronic experimental IOP elevation,(Johnson et al 1996; Johnson et al 2000) and also in the DBA/2J mouse model. (May & Mittag 2006) A gene microarray study of the ONH in the hypertonic saline model has found over 2000 genes that were significantly regulated.…”

Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma

“…(Hernandez 2000; Morrison 2006) This was initially demonstrated in non-human primates with experimental glaucoma, where deposits of collagen and other extracellular matrix (ECM) materials were found within laminar pores. (Morrison et al 1990) Similar deposits were later described in rat eyes with chronic experimental IOP elevation,(Johnson et al 1996; Johnson et al 2000) and also in the DBA/2J mouse model. (May & Mittag 2006) A gene microarray study of the ONH in the hypertonic saline model has found over 2000 genes that were significantly regulated.…”

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients

“…Chronically elevated IOP and advanced disease stage seems to produce progressive changes in the ONH, including axonal and non-axonal effects (extracellular matrix and astrocytes), possibly resulting in a stiffer and less deformable structure. [30][31][32]47,48 Among systemic factors evaluated in our study, only diabetes was significantly associated with pressureinduced topographic changes in the ONH. The presence of diabetes in glaucoma patients was related to a smaller magnitude of changes in ONH topographic parameters after IOP reduction, even after adjusting for other covariates.…”

The relationship between deterioration and reversal of optic disc cupping in monkeys with chronic experimental high-pressure glaucoma

“…It is possible that chronic glaucoma-induced alterations in biochemical properties of the optic nerve head [4,6,13,14] that influence physical or mechanical properties of the tissue, such as compliance, elasticity, and flexibility, may have contributed to the smaller degree of reversal of cupping in eyes that showed greater deterioration of cupping in the present study. If so, the finding that the reversible change in disc appearance was directly proportional to the degree of deterioration may indicate that there is a close relation between structural changes of the optic nerve head, such as changes in the amount of nerve fiber during chronic glaucoma, and changes in the reversibility of the disc appearance during a reduction in IOP, possibly due to altered mechanical or physical properties of the optic nerve head during chronic glaucoma.…”

Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma

“…(Hernandez 2000; Morrison 2006) This was initially demonstrated in non-human primates with experimental glaucoma, where deposits of collagen and other extracellular matrix (ECM) materials were found within laminar pores. (Morrison et al 1990) Similar deposits were later described in rat eyes with chronic experimental IOP elevation,(Johnson et al 1996; Johnson et al 2000) and also in the DBA/2J mouse model. (May & Mittag 2006) A gene microarray study of the ONH in the hypertonic saline model has found over 2000 genes that were significantly regulated.…”

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients

“…Chronically elevated IOP and advanced disease stage seems to produce progressive changes in the ONH, including axonal and non-axonal effects (extracellular matrix and astrocytes), possibly resulting in a stiffer and less deformable structure. [30][31][32]47,48 Among systemic factors evaluated in our study, only diabetes was significantly associated with pressureinduced topographic changes in the ONH. The presence of diabetes in glaucoma patients was related to a smaller magnitude of changes in ONH topographic parameters after IOP reduction, even after adjusting for other covariates.…”

The relationship between deterioration and reversal of optic disc cupping in monkeys with chronic experimental high-pressure glaucoma

“…It is possible that chronic glaucoma-induced alterations in biochemical properties of the optic nerve head [4,6,13,14] that influence physical or mechanical properties of the tissue, such as compliance, elasticity, and flexibility, may have contributed to the smaller degree of reversal of cupping in eyes that showed greater deterioration of cupping in the present study. If so, the finding that the reversible change in disc appearance was directly proportional to the degree of deterioration may indicate that there is a close relation between structural changes of the optic nerve head, such as changes in the amount of nerve fiber during chronic glaucoma, and changes in the reversibility of the disc appearance during a reduction in IOP, possibly due to altered mechanical or physical properties of the optic nerve head during chronic glaucoma.…”

Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma

“…(Hernandez 2000; Morrison 2006) This was initially demonstrated in non-human primates with experimental glaucoma, where deposits of collagen and other extracellular matrix (ECM) materials were found within laminar pores. (Morrison et al 1990) Similar deposits were later described in rat eyes with chronic experimental IOP elevation,(Johnson et al 1996; Johnson et al 2000) and also in the DBA/2J mouse model. (May & Mittag 2006) A gene microarray study of the ONH in the hypertonic saline model has found over 2000 genes that were significantly regulated.…”

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients

“…Chronically elevated IOP and advanced disease stage seems to produce progressive changes in the ONH, including axonal and non-axonal effects (extracellular matrix and astrocytes), possibly resulting in a stiffer and less deformable structure. [30][31][32]47,48 Among systemic factors evaluated in our study, only diabetes was significantly associated with pressureinduced topographic changes in the ONH. The presence of diabetes in glaucoma patients was related to a smaller magnitude of changes in ONH topographic parameters after IOP reduction, even after adjusting for other covariates.…”

The relationship between deterioration and reversal of optic disc cupping in monkeys with chronic experimental high-pressure glaucoma

“…It is possible that chronic glaucoma-induced alterations in biochemical properties of the optic nerve head [4,6,13,14] that influence physical or mechanical properties of the tissue, such as compliance, elasticity, and flexibility, may have contributed to the smaller degree of reversal of cupping in eyes that showed greater deterioration of cupping in the present study. If so, the finding that the reversible change in disc appearance was directly proportional to the degree of deterioration may indicate that there is a close relation between structural changes of the optic nerve head, such as changes in the amount of nerve fiber during chronic glaucoma, and changes in the reversibility of the disc appearance during a reduction in IOP, possibly due to altered mechanical or physical properties of the optic nerve head during chronic glaucoma.…”