Optic Nerve Head Blood Flow, as Measured by Laser Speckle Flowgraphy, Is Significantly Reduced in Preperimetric Glaucoma

Shiga, Yukihiro; Kunikata, Hiroshi; Aizawa, Naoko; Kiyota, Naoki; Maiya, Yukiko; Yokoyama, Yû; Omodaka, Kazuko; Takahashi, Hidetoshi; Yasui, Tomoki; Kato, Keiichi; Iwase, Aiko; Nakazawa, Toru

doi:10.3109/02713683.2015.1127974

Cited by 101 publications

(75 citation statements)

References 39 publications

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“…Therefore, it is plausible that vascular insufficiency of the small vessels occurs in the prelaminar region of the glaucomatous optic disc. This finding might agree with previous reports on preperimetric glaucoma using laser speckle flowgraphy 13,17 and the microsphere method. 13 However, the discriminatory power of the PLFI/UA to differentiate eyes with POAG from normal eyes was weak compared to the VD (AUC 0.832, P ¼ 0.002, Table 5).…”

Section: Discussionsupporting

confidence: 78%

Discriminatory Power of Superficial Vessel Density and Prelaminar Vascular Flow Index in Eyes With Glaucoma and Ocular Hypertension and Normal Eyes

Chihara¹,

Dimitrova

Amano³

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We evaluate the ability of optical coherence tomography angiography parameters, such as the peripapillary vessel density of the superficial retina and prelaminar flow index of the optic disc (PLFI), to differentiate primary open-angle glaucoma (POAG) and ocular hypertension (OH) from normal eyes. METHODS.The vessel density, PLFI, mean deviation of the visual field, circumpapillary retinal nerve fiber layer thickness (cpNFLT), and global loss volume of the ganglion cell complex were evaluated in one eye of 105 subjects with POAG and OH and normal eyes. The discriminatory powers of these parameters were evaluated based on the area under the curve (AUC) of the receiver operation characteristic curve and multiple comparisons.RESULTS. The vessel density (P < 0.001) and PLFI/unit area (PLFI/UA; P ¼ 0.020) in eyes with POAG were significantly less than in normal eyes. The vessel density in eyes with OH was significantly (P ¼ 0.018) reduced, whereas the PLFI/UA, global loss volume and cpNFLT were unaffected. The AUCs of the vessel density to discriminate glaucoma and OH from normal eyes were 0.832 and 0.724, respectively, and were significantly better than the PLFI/UA, in which the AUCs were 0.662 (P ¼ 0.002) and 0.569 (P ¼ 0.038), respectively. The powers of the vessel density and PLFI/UA to discriminate POAG from normal eyes were inferior to the global loss volume (P ¼ 0.006 and <0.0001) and cpNFLT (P ¼ 0.055 and P < 0.0001, respectively). CONCLUSIONS.The vessel density and PLFI/UA decreased significantly in glaucomatous eyes. The vessel density was more efficient than the PLFI/UA for differentiating glaucoma and OH from normal eyes.

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Section: Discussionsupporting

confidence: 78%

Discriminatory Power of Superficial Vessel Density and Prelaminar Vascular Flow Index in Eyes With Glaucoma and Ocular Hypertension and Normal Eyes

Chihara¹,

Dimitrova

Amano³

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…However, when measured in the circumpapillary area the decrease was often not significant [25, 28]. A possible explanation for this difference is the larger measurement area of the whole image, which may be able to better detect early vessel dropout [82]. With the OMAG algorithm, the blood flow index showed significant results, while vessel density often did not [22, 46].…”

Section: Resultsmentioning

confidence: 99%

Optical Coherence Tomography Angiography in Glaucoma: A Review

et al. 2018

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Background: Glaucoma is the leading cause of irreversible blindness worldwide. Several techniques exist for the diagnosis and follow-up of patients. Optical coherence tomography (OCT) angiography (OCTA) is a recently developed technique that provides a quantitative assessment of the microcirculation of the retina and choroid in a fast, noninvasive way. Despite it being a novel technique, several publications have already been done in the glaucoma field. However, a summary of findings is currently lacking. Aims: To perform a literature review to assess the role of OCTA in glaucoma diagnosis and follow-up. Methods: A database search was carried out using MEDLINE, Embase, and Web of Science, including all original works registered until July 23, 2017. Results: OCTA (1) has a high repeatability and reproducibility, (2) has good discriminatory power to differentiate normal eyes from glaucoma eyes, (3) is more strongly correlated with visual function than conventional OCT, (4) has good discriminatory power to differentiate early-glaucoma eyes from normal eyes (i.e., at least equal to that of OCT), (5) reaches a floor effect at a more advanced disease stage than OCT, and (6) is able to detect progression in glaucoma eyes. Conclusion: OCTA shows potential to become a part of everyday glaucoma management.

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“…Dysfunction in the ONH capillaries is associated with various ocular diseases and ONH tissue blood flow is significantly associated with MD in OAG. Significantly decreased ONH blood flow is also seen in the preperimetric stage of glaucoma,23 preceding visual field loss. Therefore, these previous findings strongly suggest that systemic oxidative stress may cause decreased tissue blood flow in the ONH and that systemic oxidative stress may be a cause of various upstream events in glaucomatous optic neuropathy.…”

Section: Discussionmentioning

confidence: 93%

The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma

et al. 2016

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Optic Nerve Head Blood Flow, as Measured by Laser Speckle Flowgraphy, Is Significantly Reduced in Preperimetric Glaucoma

Abstract: ONH blood flow was detectibly reduced in eyes with PPG, in close association with structural and visual field damage. This suggests that measuring ONH tissue-area blood flow with LSFG may be a useful way of monitoring glaucoma severity, even in the early stages of glaucoma.

Cited by 101 publications

References 39 publications

Discriminatory Power of Superficial Vessel Density and Prelaminar Vascular Flow Index in Eyes With Glaucoma and Ocular Hypertension and Normal Eyes

Discriminatory Power of Superficial Vessel Density and Prelaminar Vascular Flow Index in Eyes With Glaucoma and Ocular Hypertension and Normal Eyes

Optical Coherence Tomography Angiography in Glaucoma: A Review

The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma

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