Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: Evidence that axonal loss is a substrate of MRI-detected atrophy

Trip, S Anand; Schlottmann, Patricio G.; Jones, Stephen J.; Yu, Wai‐Yung; Garway-Heath, David F.; Thompson, Alan J.; Plant, Gordon T.; Miller, David H.

doi:10.1016/j.neuroimage.2005.11.051

Cited by 183 publications

(163 citation statements)

References 45 publications

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“…Studies with optic coherence tomography have demonstrated axonal loss in the retinal nerve fiber layer in patients with MS in the early stages of the disease [30][31][32]. This early axonal loss is probably the reason why most of our patients with subsequent MS conversion had incomplete recovery after the first clinical presentation of the disease.…”

Section: Discussionmentioning

confidence: 79%

Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI

Marques

Matias

Silva

et al. 2014

Journal of Clinical Neuroscience

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a b s t r a c tWhen assessing and managing a patient with optic neuritis (ON), the risk of future development of multiple sclerosis (MS) is an important issue, as this can be the first presentation of the disease. Although the presence of lesions on baseline brain MRI is the strongest predictor of MS conversion, some patients with normal imaging also develop MS. We aimed to estimate MS risk in patients with ON and a normal baseline MRI and identify individuals with higher risk of conversion. We performed a retrospective study including patients with idiopathic ON and normal baseline brain MRI who presented to our hospital over an 8 year period. Of a total of 42 patients, 10 converted to MS: five during the first follow-up year, seven during the first 2 years and all of the patients within the first 5 years, with a 5 year MS conversion rate of 23.8%. MS conversion rates were significantly higher in patients with history of previous symptoms suggestive of demyelination (p = 0.002), cerebrospinal fluid oligoclonal bands unmatched in serum (p = 0.004) and incomplete visual acuity recovery (66/12) after 1 year (p = 0.002). Lower conversion rates were found in patients with optic disc edema (p = 0.022). According to these results, a significant proportion of patients with idiopathic ON and a normal baseline brain MRI will develop MS, with a higher risk during the first 5 years. Therefore, in the presence of factors in favor of MS conversion, close follow-up, including semestral medical consultations and yearly brain MRI, can be recommended. Early immunomodulatory treatment may be individually considered as it can delay conversion and reduce new lesion development rate.

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Section: Discussionmentioning

confidence: 79%

Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI

Marques

Matias

Silva

et al. 2014

Journal of Clinical Neuroscience

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“…However, surface coils focusing on the orbit may further improve the image quality. 89 Important MRI methods for research purposes include measures of optic nerve atrophy obtained using highresolution 3D T2-weighted sequences, 90 quantitative MRI techniques91 and diffusion tensor imaging. 92 These advanced techniques can assist in the early detection of clinical impairment, and enable quantitative estimation of the presence and extent of damage to the optic nerve.…”

Section: Research Protocolmentioning

confidence: 99%

The investigation of acute optic neuritis: a review and proposed protocol

et al. 2014

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| Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.

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“…These OCTs offer faster scan speed and higher image resolution for RNFL imaging than conventional time-domain OCT. 2 Several studies have focused on the measurements and reproducibility of RNFL thickness using Stratus-OCT after optic neuritis (ON) and multiple sclerosis (MS). [3][4][5][6][7][8][9][10][11][12][13] In fact, lower RNFL values correlate with impaired visual function. OCT is a promising tool for evaluating atrophy in patients with ON and MS, and it could evolve into an important primary or secondary outcome measure for MS clinical trials and patient care.…”

Section: Introductionmentioning

confidence: 99%

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Rebolleda

García-García²,

Kim³

et al. 2010

Eye

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Purpose To study the relationship between retinal nerve fiber layer (RNFL) thickness measurements from time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT) in subjects with optic neuritis. Methods A total of 18 patients who had suffered monocular acute optic neuritis were imaged by a single trained operator using the Stratus-OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) on the same day. The relationship between RNFL thickness measurements of the two OCTs (overall and by quadrants) were evaluated using intraclass correlation coefficient (ICC) and Bland-Altman plots. Comparisons between eyes having optic neuritis (ON-group) and fellow eyes (fellow-group) were assessed by a generalized estimating equation (GEE) regression model.

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Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: Evidence that axonal loss is a substrate of MRI-detected atrophy

Cited by 183 publications

References 45 publications

Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI

Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI

The investigation of acute optic neuritis: a review and proposed protocol

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

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