Optic nerve abnormalities in children: A practical approach

Capó, Hilda; Repka, Michael X.; Edmond, Jane C.; Drack, Arlene V.; Blumenfeld, Louis C.; Siatkowski, R. Michael

doi:10.1016/j.jaapos.2011.02.010

Cited by 6 publications

(2 citation statements)

References 61 publications

(79 reference statements)

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“…Direct ophthalmoscopy is an excellent way to see the optic disc and is important in diagnosing papilloedema, coloboma and congenital dysplastic optic discs 1. Optic nerve abnormalities in children are often related to systemic disease and early diagnosis can avoid comorbidity.…”

Section: Physiological Backgroundmentioning

confidence: 99%

How to use…the direct ophthalmoscope

Gurney

Makanjuola

Kutubi

et al. 2017

Arch Dis Child Educ Pract Ed

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Ophthalmoscopy and red reflex examination are core medical skills required to identify sight-threatening and life-threatening disease. We discuss the predictive utility and limitations of findings with an ophthalmoscope and tips as to how to optimise these. We outline important considerations in three clinical scenarios: an abnormal red reflex, an abnormal optic disc and retinal haemorrhages in the context of child protection concerns.

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Section: Physiological Backgroundmentioning

confidence: 99%

How to use…the direct ophthalmoscope

Gurney

Makanjuola

Kutubi

et al. 2017

Arch Dis Child Educ Pract Ed

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“…1–4 Correspondingly, there is a reduced number of retinal ganglion cells and thinning or absence of the retinal nerve fiber layer (RNFL). 5,6 Visual acuity in patients with ONH can range from light perception to normal visual acuity.…”

mentioning

confidence: 99%

Macular optical coherence tomography in patients with unilateral optic nerve hypoplasia

Abbasian¹,

Blair²,

Shahidi³

et al. 2015

Journal of American Association for Pediatric Ophthalmology and

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PURPOSE To characterize the extent and location of macular thinning in patients with unilateral optic nerve hypoplasia (ONH) as compared to the contralateral normal eye. METHODS The medical records of patients with unilateral ONH who underwent spectral domain optical coherence tomography (SD-OCT) of the macula were retrospectively reviewed. SD-OCT scans were manually segmented by 3 observers in 3 macular regions (superior, central, inferior). Boundaries identified included the inner limiting membrane, the junction between the inner nuclear layer and outer plexiform layer, and the neural retina–retinal pigment epithelium interface. Using custom MATLAB software, inner and outer retinal thickness profiles were quantified. A paired t test was used to compare the retinal thickness between the ONH eye and the contralateral normal eyes. RESULTS Inner retinal thickness of the ONH eye was decreased in all areas of the macula (superior, central, and inferior) compared to the contralateral normal eye (P < 0.05). Outer retinal thicknesses were also decreased in the central and inferior sections compared with the normal eye (P < 0.05). CONCLUSIONS Optic nerve hypoplasia is a congenital disease known to result in thinning of the nerve fiber and ganglion cell layer. Our small cohort demonstrated thinning of the inner retinal layers as well as the outer retinal layers in the ONH eye compared with the contralateral normal eye.

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Congenital Optic Nerve Anomalies

Brodsky¹

2016

Pediatric Neuro-Ophthalmology

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Optic nerve abnormalities in children: A practical approach

Cited by 6 publications

References 61 publications

How to use…the direct ophthalmoscope

How to use…the direct ophthalmoscope

Macular optical coherence tomography in patients with unilateral optic nerve hypoplasia

Congenital Optic Nerve Anomalies

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