Opsonically-Active Proteins in CAPD Fluid

Yewdall, V. M. A.; Bennett-Jones, David; Cameron, J. S.; Ogg, C S; Williams, D G

doi:10.1007/978-3-662-11784-2_109

Cited by 8 publications

(6 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can possibly be attributed to the use of differ ent assays. The dialysate fibronectin concen trations we measured after recovery from the infection were similar to those reported in peritoneal effluent of uninfected CAPD pa tients by other groups [3,13,14], Serum fibronectin levels remained stable during peritonitis and were not different from values measured after recovery. This is in contradiction to a study by Giacchino et al, that reported lower plasma levels during peri toneal inflammation [16].…”

Section: Discussionsupporting

confidence: 72%

“…These observations are in favor of transperitoneal transport of fibronectin from the circu lation towards the dialysate and do not sug gest local intraperitoneal synthesis. This con firms reports in stable uninfected CAPD pa tients from Yewdall et al [13] and Davies et al [14], It has been reported that potential interactions exist between fibronectin and heparin [21,22]. In our own laboratory we measured 4-8% lower fibronectin concentra tions after addition of heparin to dialysate (500 IU/1) obtained on the first day of perito nitis (data not shown).…”

Section: Discussionsupporting

confidence: 54%

“…In addition, several au thors have measured fibronectin in peritoneal effluent from stable patients treated with CAPD [3,13,14]. However, it is still unclear whether fibronectin present in peritoneal ef fluent is synthesized locally within the perito neal cavity, as suggested by some authors [15], or derived from the circulation by transperitoneal transport, as proposed by others [13,14], Furthermore, both increased and de creased peritoneal fibronectin levels have been reported during peritoneal inflamma tion [15,16],…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fibronectin during CAPD-Related Peritonitis: No Indications for Intraperitoneal Production

Zemel¹,

Koomen

Struijk³

et al. 1993

Blood Purif

View full text Add to dashboard Cite

Fibronectin is a 440-kD MW glycoprotein involved in opsonization and adhesion of cells to collagen. We examined 13 episodes of peritonitis on 8 consecutive days from the start and once after recovery (control). Fibronectin clearance was compared to that of marker proteins for peritoneal transport. Increased dialysate fibronectin levels were observed on the first peritonitis day. They declined during recovery. Serum levels were stable during peritonitis. All protein clearances, including fibronectin, were increased during the acute phase and decreased during recovery. The clearance of fibronectin showed a time course similar to that of the marker proteins. It was in the range between IgG (150 kD) and α₂-macroglobulin (820 kD), thus as expected on the basis of its molecular weight. We conclude that elevated dialysate fibronectin levels observed during peritonitis are due to increased transperitoneal transport and not to local synthesis. This augmented transport results from increments in both effective surface area and intrinsic permeability of the peritoneum.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fibronectin during CAPD-Related Peritonitis: No Indications for Intraperitoneal Production

Zemel¹,

Koomen

Struijk³

et al. 1993

Blood Purif

View full text Add to dashboard Cite

show abstract

“…[67] Across all studies in this review, prevalence of SLE among patients with SIgAD was 1.25%, compared to 0.24%, the highest accepted prevalence of SLE in the general population. [66,[68][69][70][71][72][73][74][75][76][77][78][79][80] (Table 2) As is the case with many of the autoimmune conditions considered here, SLE has been increasing in prevalence in many populations, so older studies may underestimate the modern prevalence of SLE in this population. [68] Among patients with known SLE, the prevalence of SIgAD is approximately 2.02%, which is much higher than the prevalence of SIgAD observed in any healthy population.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…[170] A single study noted the prevalence of SIgAD among individuals with glomerulonephritis as 0.7%, compared to 0% of a healthy control group, and this difference was not statistically significant. [80] Two studies reported the prevalence of glomerulonephritis in SIgAD populations, finding a weighted average of 1.49%. [22,24] (Table 26) The larger of the two studies compared the results to a control populations, and did not find a significant difference in prevalence.…”

Section: Glomerulonephritismentioning

confidence: 99%

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Odineal

Gershwin

2019

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Selective Immunoglobulin A Deficiency (SIgAD) is the most common primary immunodeficiency, defined as an isolated deficiency of IgA (less than 0.07 g/L). Although the majority of people born with IgA deficiency lead normal lives without significant pathology, there is nonetheless a significant association of IgA deficiency with mucosal infection, increased risks of atopic disease, and a higher prevalence of autoimmune disease. To explain these phenomena, we have performed an extensive literature review to define the geoepidemiology of IgA deficiency and particularly the relative risks for developing Systemic Lupus Erythematosus, hyperthyroidism, hypothyroidism, type 1 diabetes mellitus, Crohn's Disease, ulcerative colitis, rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and vitiligo; these diseases have strong data to support an association. We also note weaker associations with scleroderma, celiac disease, autoimmune hepatitis, immune thrombocytopenic purpura, and autoimmune hemolytic anemia. Minimal if any associations are noted with myasthenia gravis, lichen planus, and multiple sclerosis. Finally, more recent data provide clues on the possible immunologic mechanisms that lead to the association of IgA deficiency and autoimmunity; these lessons are important for understanding the etiology of autoimmune disease. 2 3 Introduction:

show abstract

Lectin-Mediated, Nonopsonic Phagocytosis of Type 1 Escherichia coli by Human Peritoneal Macrophages of Uremic Patients Treated by Peritoneal Dialysis

et al. 1989

View full text Add to dashboard Cite

Human peritoneal macrophages isolated from uremic patients undergoing peritoneal dialysis bind type 1 fimbriated Escherichia coli in the absence of opsonins. The number of bacteria bound per macrophage was 6.9, as determined by microscopic examination. Methyl alpha-mannoside (0.1 mM) and p-nitrophenyl alpha-mannoside (0.01 mM) inhibited this binding by about 66%. The ability of peritoneal macrophages to bind E. coli in a mannose-specific manner was confirmed in further experiments using an enzyme-linked immunosorbent assay (ELISA) with an antibacterial antibody, radiolabelled E. coli, and counts of colony-forming units (CFU). The number of bacteria bound per macrophage was 7 to 12 in the ELISA and 5.5-8.5 in the CFU assay. Methyl alpha-mannoside caused 70% inhibition of binding in the ELISA and 84% in the CFU assay, whereas p-nitrophenyl alpha-mannoside showed inhibition of 79% and 90%, respectively. Most bound bacteria (76-80%) were subsequently killed. Nonfimbriated E. coli 827 bound poorly to the macrophages (approximately 22%) as compared to that of the fimbriated bacteria. Although this binding was not inhibited by methyl alpha-D-mannoside or p-nitrophenyl alpha-mannoside, the percentage of bacteria killed was similar to that of the fimbriated phenotype. The peritoneal macrophage is thus able to phagocytose E. coli in the absence of opsonins. This may explain the relative rarity of E. coli as an etiologic agent of peritoneal infections in the dialysed patient.

show abstract

Opsonically-Active Proteins in CAPD Fluid

Cited by 8 publications

References 2 publications

Fibronectin during CAPD-Related Peritonitis: No Indications for Intraperitoneal Production

Fibronectin during CAPD-Related Peritonitis: No Indications for Intraperitoneal Production

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Lectin-Mediated, Nonopsonic Phagocytosis of Type 1 Escherichia coli by Human Peritoneal Macrophages of Uremic Patients Treated by Peritoneal Dialysis

Contact Info

Product

Resources

About