Opsonic Activity, Phagocytosis, and Bactericidal Capacity of Polymorphs in Undernutrition

Malnutrition and Infection

“…Abnormalities of phagocyte cell function in these patients are thus subtle. Often they appear to be a consequence of infection per se, rather than of the malnutrition per se (Douglas and Schopfer, 1974;Jose et at., 1975;Keusch et at., 1977a;Rosen et at., 1975;Seth and Chandra, 1972). Even in otherwise normal hosts, infections lead to quantitative defects in phagocytic cell function, perhaps because of mobilization of younger, functionally immature cells (McCall et at., 1969(McCall et at., , 1971.…”

Paediatric oncology in developing countries

“…Impaired immune regulation by T-cell subsets results in suboptimal antibody responses to vaccination antigens [6,73]. Chemotaxis, bactericidal and fungicidal functions of neutrophils are reduced [74]. At least in protein malnourished mice, macrophage functions initiating immune responses also are severely impaired [71].…”

Cellular and Plasma-Associated Phagocytic Defects Amongst Iranian Blood Donors

“…Although the association of mal nutrition and susceptibility to infection is established [10], studies of professional blood donors in this context have been sparse. Repeated venesection or haemor rhage are known to cause the immediate release of phagocytic cells from the bone marrow.…”

“…data regarding phagocytic function in pro fessional blood donors although Chandra [2] and Seth and Chandra [10] have docu mented defective bactericidal and opsonic activity in patients suffering from malnutri tion and iron deficiency [3], Until 1973, all blood used for transfusion in Iran was purchased from professional blood donors who regularly sold 300 ml of blood up to three times per week. These do nors were, almost without exception, pro foundly iron deficient, anaemic and mal nourished.…”