Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes <i>via </i>Mitochondrial Pathway

Wang, Y; Lan, Yan‐Yu; Lü, Hongguang

doi:10.1111/php.13178

Cited by 35 publications

(48 citation statements)

References 55 publications

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“…In 2020, Wang et al reported that OPN3 is a key receptor responsible for survival of human epidermal melanocytes 59 . They observed that downregulation of OPN3 markedly reduces the intracellular calcium level and triggers the conventional apoptosis pathway via mitochondria.…”

Section: Resultsmentioning

confidence: 99%

The expression of opsins in the human skin and its implications for photobiomodulation: A Systematic Review

Suh

Choi

Mesinkovska

2020

Photoderm Photoimm Photomed

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Background Skin is the organ most extensively exposed to light of a broad range of wavelengths. Several studies have reported that skin expresses photoreceptive molecules called opsins. However, the identity and functional role of opsins in the human skin remain elusive. We aim to summarize current scientific evidence on the types of opsins expressed in the skin and their biological functions. Methods A primary literature search was conducted using PubMed to identify articles on dermal opsins found in nonhuman animals and humans. Results Twenty‐two articles, representing, however, a non‐exhaustive selection of the scientific papers published in this specific field, met the inclusion criteria. In nonhuman animals, opsins and opsin‐like structures have been detected in the skin of fruit fly, zebrafish, frog, octopus, sea urchin, hogfish, and mouse, and they mediate skin color change, light avoidance, shadow reflex, and circadian photoentrainment. In humans, opsins are present in various skin cell types, including keratinocytes, melanocytes, dermal fibroblasts, and hair follicle cells. They have been shown to mediate wound healing, melanogenesis, hair growth, and skin photoaging. Conclusion Dermal opsins have been identified across many nonhuman animals and humans. Current evidence suggests that opsins have biological significance beyond light reception. In nonhuman animals, opsins are involved in behaviors that are critical for survival. In humans, opsins are involved in various functions of the skin although the underlying molecular mechanisms remain unclear. Future investigation on elucidating the mechanism of dermal opsins will be crucial to expand the therapeutic benefits of photobiomodulation for various skin disorders.

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Section: Resultsmentioning

confidence: 99%

The expression of opsins in the human skin and its implications for photobiomodulation: A Systematic Review

Suh

Choi

Mesinkovska

2020

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

show abstract

“…Cytochrome c induces the sequential activation of the caspase cascades, including the activation of caspase9, which then activates downstream caspase3 ( Meng et al, 2012 ; Zhang et al, 2015 ). Different members of the Bcl-2 family of proteins, such as Bax, seem to control the release of cytochrome c ( Wang et al, 2020 ; Yusuf and Casey, 2020 ). Bax plays a role in increasing the permeability of the mitochondrial outer membrane for releasing cytochrome c into the extracorporeal mitochondrial environment ( Ott et al, 2002 ; Pagliari et al, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head

Yan

Zhan

et al. 2020

Front. Pharmacol.

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Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Luteolin (Lut), a compound extracted from Rhizoma Drynariae, is reported to possess multiple pharmacological properties including anticancer, antioxidant, antiapoptosis, and antiinflammatory properties. However, whether Lut has a protective effect on the development of GIONFH remains unclear. In this study, we evaluated the effect of Lut on Dexamethasone (Dex)-induced STAT1/caspase3 pathway in vitro and evaluated GIONFH model in vivo. In vitro, Lut inhibited the upregulation of Dex-induced phospho-STAT1, cleaved caspase9, and cleaved caspase3. In addition, Lut inhibited Dex-induced expression of Bax and cytochrome c and increased the expression of B cell lymphoma-2 (Bcl-2). In vivo, Lut decreased the proportion of empty lacunae in rats with GIONFH. Taken together, these findings indicate that Lut may have therapeutic potential in the treatment of GIONFH. Further, this effect might be achieved by suppressing mitochondrial apoptosis of osteoblasts via inhibition of STAT1 activity.

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“…MAP3K5 is a reliable marker for dominant follicles in cattle, and at day 2.5 post-ovulation there are clear differences in expression of MAP3K5 between the dominant follicle and the next largest follicle a day later [41][42]. Panda et al (2002) concluded that Opn4 is required for light-induced circadian phase shifting, and OPNs play a pivotal role in non-image-forming responses to light, including physiological adaptations to ambient light [43][44]. PIK3R1 plays an important role in regulating ovarian activities in yak seasonal reproduction [45].…”

Section: Discussionmentioning

confidence: 99%

CircRNA Expression in Chicken Granulosa Cells Illuminated with Red Light

Wang

Guo

Chen

et al. 2020

Preprint

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Background Our previous work revealed that red light (RL) can improve egg production by Jinghai Yellow hens. Circular RNAs (circRNAs) are a novel non-coding RNAs, but the molecular mechanism underpinning their functions during follicular development of hens under monochromatic light remains unknown. Results We compared expression profiles of granulosa cells (GCs) of small yellow follicles (SYFs) from hens under RL and white light (WL). A total of 2,468 circRNAs were identified, of which 22 were differentially expressed (DE) between RL and WL groups. Host genes of DE circRNAs were enriched in ovarian steroidogenesis, and MAPK signalling and PI3K-Akt signalling pathways. Furthermore, DE circRNA_0320 and circRNA_0185 interact with miR-143-3p targeting FSHR, which is essential for GC differentiation and follicle development. Conclusions These findings will facilitate further analysis of the molecular mechanism of circRNAs in GCs of SYFs, and expand our understanding of follicle development, which could lead to increased egg production.

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Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway

Cited by 35 publications

References 55 publications

The expression of opsins in the human skin and its implications for photobiomodulation: A Systematic Review

The expression of opsins in the human skin and its implications for photobiomodulation: A Systematic Review

The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head

CircRNA Expression in Chicken Granulosa Cells Illuminated with Red Light

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