A simple hydrothermal process for fabrication of hematite
(α-Fe2O3) nanostructures with narrow size
distribution
was developed by using PVP as surfactant and NaAc as precipitation
agent. The influence of experimental parameters including the concentration
of the precursor, precipitation agent, stabilizing agent, and reaction
time was systematically investigated to study the possible formation
mechanism of α-Fe2O3. Finally, the electrochemical
properties of the obtained hematite particles were studied using cyclic
voltammetry and galvanostatic charge–discharge measurement
by a three-electrode system. The results reveal that their specific
capacitances are related to their sizes. By virtue of large surface
area, the as-prepared hematite nanoparticles can present the highest
capacitance (340.5 F·g–1) and an excellent
long cycle life within the operated voltage window (−0.1 to
0.44 V), demonstrating that the as-prepared hematite nanoparticles
can serve as one of the most excellent electrode materials for supercapacitors.
BackgroundRecent studies indicated that some glycolytic enzymes are complicated, multifaceted proteins rather than simple components of the glycolytic pathway. FBP1 plays a vital role in glucose metabolism, but its role in gastric cancer tumorigenesis and metastasis has not been fully understood.MethodsThe prognostic value of FBP1 was first studied in The Cancer Genome Atlas (TCGA) database and validated in in-house database. The effect of FBP1 on cell proliferation and metastasis was examined in vitro. Nonparametric test and Log-rank test were used to evaluate the clinical significance of FBP1 expression.ResultsIn the TCGA cohort, FBP1 mRNA level were shown to be predictive of overall survival in gastric cancer (P = 0.029). In the validation cohort, FBP1 expression were inversely correlated with advanced N stage (P = 0.021) and lymphovascular invasion (P = 0.011). Multivariate Cox regression analysis demonstrated that FBP1 was an independent predictor for both overall survival (P = 0.004) and disease free survival (P<0.001). Functional studies demonstrated that ectopic FBP1 expression inhibited proliferation and invasion in gastric cancer cells, while silencing FBP1 expression had opposite effects (P<0.05). Mechanically, FBP1 serves as a tumor suppressor by inhibiting epithelial-mesenchymal transition (EMT).ConclusionsDownregulation of FBP1 promotes gastric cancer metastasis by facilitating EMT and acts as a potential prognostic factor and therapeutic target in gastric cancer.
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