Opposite effects of zinc and melatonin on thyroid hormones in rats

Baltacı, Abdülkerim Kasım; Moğulkoç, Rasim; Kul, Aylin; Bediz, Cem Şeref; Ugur, Aysegul

doi:10.1016/j.tox.2003.09.001

Cited by 69 publications

(50 citation statements)

References 28 publications

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“…In addition to its direct antioxidant characteristics, zinc may have brought about these effects through its effect on thyroid function, and therefore on thyroid hormone levels. Actually, we have found in our previous studies that zinc defi ciency reduced, while zinc supplementation elevated thyroid hormones (23,24). Zinc supplementation in addition to hypothyroidism signifi cantly reduced MDA levels in both tissues, whereas zinc defi ciency brought about critical increases in this parameter.…”

Section: Tab 1 Mda (Nmol/ml) and Gsh (Mg/dl) Levels Of Study Groupsmentioning

confidence: 82%

Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism: the role of zinc

Baltacı¹,

Moğulkoç²,

Ayyıldız³

et al. 2014

BLL

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Abstract:The aim of the present study was to determine the effect of zinc supplementation and zinc defi ciency on the lipid peroxidation in the testis and kidney tissues of rats with experimentally induced hypothyroidism. The experimental Groups were formed as follows: 1 -Control; 2 -Sham-Hypothyroidism; 3 -Hypothyroidism (intraperitoneal administration of 10 mg/kg/day PTU for 4 weeks); 4 -Hypothyroidism + 3 mg/kg/day zinc supplementation (4 weeks); 5 -Hypothyroidism + zinc defi ciency (4 weeks). The examination of the study results revealed that hypothyroidism in testis and kidney tissues increased MDA levels and decreased GSH levels (p<0.001). Zinc supplementation in addition to hypothyroidism, however, reduced the increased MDA amount and elevated GSH levels (p<0.001). Zinc defi ciency together with hypothyroidism, on the other hand, was found to produce the opposite results (p<0.001). The results of the study indicated that experimental hypothyroidism caused lipid peroxidation in kidney and testis tissues. Zinc defi ciency together with hypothyroidism made lipid peroxidation more evident, while zinc supplementation signifi cantly inhibited the increased oxidative stress by activating the antioxidant system (Tab. 1, Ref. 24). Text in PDF www.elis.sk.

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Section: Tab 1 Mda (Nmol/ml) and Gsh (Mg/dl) Levels Of Study Groupsmentioning

confidence: 82%

Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism: the role of zinc

Baltacı¹,

Moğulkoç²,

Ayyıldız³

et al. 2014

BLL

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“…In addition, several trace elements are needed for the normal function, synthesis and metabolism of thyroid hormones. In particular, it has been indicated that deficiencies in the levels of selenium (Beckett and Arthur, 2005) and zinc (Baltaci et al, 2004) have a suppressing effect on thyroid hormones. Thus, it seems that having a good nutrition could be a reason for unchanged levels of thyroid hormones in the infected animals.…”

Section: Discussionmentioning

confidence: 99%

Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Razavi¹,

Moghaddas²,

Rakhshande³

et al. 2015

Research J. of Parasitology

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Tropical theileriosis of cattle is a common tick-borne disease in tropical and subtropical regions and is recognized as a disease of major economic importance. This study aimed to determine whether Theileria annulata infection influences the plasma homocystein (Hcy), thyroid activity and serum lipid status in infected cattle. Fifty crossbred Holstein cattle, naturally infected with Theileria annulata were selected and divided into 3 subgroups according to their parasitemia rates (<2, 2-4, 4-8%). Also, 10 non-infected cattle were assigned as controls. Blood samples were collected and hematological parameters, plasma Homocystein (Hcy), thyroid hormones (T 3 , T 4 , free T3 (fT 3 ) and free T 4 (fT 4 )) and the concentrations of serum lipid and lipoproteins (cholesterol, triglyceride and lipoproteins including HDL, LDL and VLDL cholesterol) and phosphatidylserine (PS) on erythrocytes were measured. According to the results, significant elevations were observed in the concentration of plasma Hcy (hyperhomocysteinemia) in the infected groups compared to controls. In addition, we conclude that T. annulata can interfere with the lipid metabolism, which is particularly characterized by substantial decreases in the levels of cholesterol, LDL and HDL in the serum of affected animals. In spite of remarkable influences of the parasite on Hcy and lipid contents of the serum, our study proved that tropical theileriosis did not affect the thyroid hormones during parasitemia. This study demonstrates that the infection of cattle with Theileria annulata is mainly characterized by the anemia. Also, evidenced elevation in the level of homocystein (hyperhomocysteinemia) in parasitized cattle can result in oxidative stress on erythrocytes and the probable endothelial injuries. In addition, T. annulata can induce failure in lipid metabolism which is particularly featured by a decrease in the cholesterol, LDL-cholesterol and HDL-cholesterol concentrations; however the parasite cannot implement significant influences on the thyroid hormones in the affected cattle.

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“…The urinary space has been restored to relatively normal in alloxan induced rats after treatment with Mel. Studies have demonstrated Mel enhances the absorption of Zn from the intestines [51,52]. Baltaci et al [52] reported that Mel administration increased plasma Zn levels even in pinealactomized rats.…”

Section: Effect Of Melmentioning

confidence: 99%

Effect of Chromium Picolinate and Melatonin either in Single or in a Combination in Alloxan Induced Male Wistar Rats

Doddigarla¹,

Parwez²,

Abidi³

et al. 2017

J Biomedical Sci

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Opposite effects of zinc and melatonin on thyroid hormones in rats

Cited by 69 publications

References 28 publications

Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism: the role of zinc

Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism: the role of zinc

Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Effect of Chromium Picolinate and Melatonin either in Single or in a Combination in Alloxan Induced Male Wistar Rats

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