Opposing roles of IL‐17A and IL‐25 in the regulation of TSLP production in human nasal epithelial cells

Abstract

Our study provides the first evidence that both IL-17F and IL-25 can be induced by dsRNA in HNECs. Despite of the opposing effects of IL-17A and IL-25 on TSLP regulation in HNECs, IL-25 was dominant to IL-17A, providing a plausible explanation for the simultaneous upregulation of IL-17 cytokines and TSLP in patients with AR.

IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

“…Three ligands, IL-17A, IL-17F, and IL-25, have been reported capable of signaling through IL-17RA [34]. Previous report demonstrated that IL-17F and IL-25 played opposing roles of IL-17A in the regulation of lymphopoiethin production in human nasal epithelial cells [35]. Our study found that IL-17F was also elevated in BALF of mice infected with BJ501 live virus ( Figure 6B).…”

Plasminogen Kringle 5 Induces Endothelial Cell Apoptosis by Triggering a Voltage-dependent Anion Channel 1 (VDAC1) Positive Feedback Loop

“…Quantitative Real-time PCR (qPCR)-The qPCR was performed as previously described (22,23). In brief, total RNA was extracted from HUVECs by TRIzol Reagent (Invitrogen).…”

The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity

“…The IL-17E level is higher in nasal lavages from allergic rhinitis patients than normal controls. 148 Upon allergen challenge, IL-17E is increased in the bronchial mucosa of asthmatic patients and the skin dermis of atopic subjects. 149 Consistently, IL-17E mRNA is increased in the airways of antigen-challenged mice.…”